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Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome?
Eur J Obstet Gynecol Reprod Biol. 2004 Aug 10; 115(2):194-9.EJ

Abstract

OBJECTIVE(S)

The aim of this study was to measure concentrations of vascular endothelial growth factor (VEGF), inhibin A and inhibin B in follicular fluid (FF) of women undergoing to in vitro fertilization (IVF) cycles and to determine their relationship with ovarian response and pregnancy.

STUDY DESIGN

Follicular fluid was collected from 58 patients undergoing oocyte retrieval for IVF. Ovulation was induced with GnRH analogues and gonadotropins. Follicular fluids of mature follicles (>17 mm) were aspirated and pooled for each patient. Follicular fluid steroid hormone levels (E2, P) and VEGF, inhibin A, inhibin B concentrations were studied. The serum levels of E2, P and VEGF were also assessed on the day of the oocyte retrieval. These parameters and characteristics of the cycles were compared between the pregnant (group 1) and non pregnant (group 2) patients.

RESULTS

The serum and FF VEGF levels were found to be significantly lower in the group in whom the pregnancy was achieved (P < 0.001). The FF inhibin A and FF inhibin B were found to be significantly higher in pregnant group (P < 0.001). However, age, day 3 FSH, dosage of gonadotropin administered, fertilization rate, sperm count, motile and morphologically normal sperm percentage were not significantly different in the two groups. There was an negative correlation between VEGF and number of follicles, number of oocytes, FF inhibin A, FF inhibin B. The number of oocytes retrieved, the fertilization rate were positively correlated with FF inhibin B and FF inhibin A.

CONCLUSION

This study demonstrated that decreased FF VEGF, serum VEGF and elevated FF inhibin A and B are associated with better ovarian response and high pregnancy rate.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Cerrahpasa Medical School, Istanbul University, ART Unit, Turkey. ocal-pelin@lycos.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15262355

Citation

Ocal, Pelin, et al. "Follicular Fluid Concentrations of Vascular Endothelial Growth Factor, Inhibin a and Inhibin B in IVF Cycles: Are They Markers for Ovarian Response and Pregnancy Outcome?" European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 115, no. 2, 2004, pp. 194-9.
Ocal P, Aydin S, Cepni I, et al. Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome? Eur J Obstet Gynecol Reprod Biol. 2004;115(2):194-9.
Ocal, P., Aydin, S., Cepni, I., Idil, S., Idil, M., Uzun, H., & Benian, A. (2004). Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome? European Journal of Obstetrics, Gynecology, and Reproductive Biology, 115(2), 194-9.
Ocal P, et al. Follicular Fluid Concentrations of Vascular Endothelial Growth Factor, Inhibin a and Inhibin B in IVF Cycles: Are They Markers for Ovarian Response and Pregnancy Outcome. Eur J Obstet Gynecol Reprod Biol. 2004 Aug 10;115(2):194-9. PubMed PMID: 15262355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome? AU - Ocal,Pelin, AU - Aydin,Seval, AU - Cepni,Ismail, AU - Idil,Sevda, AU - Idil,Mehmet, AU - Uzun,Hafize, AU - Benian,Ali, PY - 2003/08/02/received PY - 2003/10/22/revised PY - 2004/01/30/accepted PY - 2004/7/21/pubmed PY - 2004/12/16/medline PY - 2004/7/21/entrez SP - 194 EP - 9 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 115 IS - 2 N2 - OBJECTIVE(S): The aim of this study was to measure concentrations of vascular endothelial growth factor (VEGF), inhibin A and inhibin B in follicular fluid (FF) of women undergoing to in vitro fertilization (IVF) cycles and to determine their relationship with ovarian response and pregnancy. STUDY DESIGN: Follicular fluid was collected from 58 patients undergoing oocyte retrieval for IVF. Ovulation was induced with GnRH analogues and gonadotropins. Follicular fluids of mature follicles (>17 mm) were aspirated and pooled for each patient. Follicular fluid steroid hormone levels (E2, P) and VEGF, inhibin A, inhibin B concentrations were studied. The serum levels of E2, P and VEGF were also assessed on the day of the oocyte retrieval. These parameters and characteristics of the cycles were compared between the pregnant (group 1) and non pregnant (group 2) patients. RESULTS: The serum and FF VEGF levels were found to be significantly lower in the group in whom the pregnancy was achieved (P < 0.001). The FF inhibin A and FF inhibin B were found to be significantly higher in pregnant group (P < 0.001). However, age, day 3 FSH, dosage of gonadotropin administered, fertilization rate, sperm count, motile and morphologically normal sperm percentage were not significantly different in the two groups. There was an negative correlation between VEGF and number of follicles, number of oocytes, FF inhibin A, FF inhibin B. The number of oocytes retrieved, the fertilization rate were positively correlated with FF inhibin B and FF inhibin A. CONCLUSION: This study demonstrated that decreased FF VEGF, serum VEGF and elevated FF inhibin A and B are associated with better ovarian response and high pregnancy rate. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/15262355/Follicular_fluid_concentrations_of_vascular_endothelial_growth_factor_inhibin_A_and_inhibin_B_in_IVF_cycles:_are_they_markers_for_ovarian_response_and_pregnancy_outcome L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301211504000697 DB - PRIME DP - Unbound Medicine ER -