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Glucose permeable poly (dimethyl siloxane) poly (N-isopropyl acrylamide) interpenetrating networks as ophthalmic biomaterials.

Abstract

Poly (dimethyl siloxane) (PDMS) has been widely used as a biomaterial in ophthalmic and other applications due to its good compatibility, high mechanical strength, excellent oxygen permeability and transparency. However, for use as an artificial cornea, contact lens and in other applications, modifications with hydrophilic functional groups or polymers are necessary to improve wettability for tear protein and mucin interactions and to improve glucose permeability for cellular health. Poly (N-isopropyl acrylamide) (PNIPAAM) is a biocompatible and hydrophilic polymer that has been extensively studied on controlled drug release applications due to its lower critical solution temperature (LCST) phenomenon. In the current work, a composite interpenetrating network (IPN) of PDMS and PNIPAAM was formed to generate polymers with oxygen and glucose permeability as well as improved wettability compared to PDMS homopolymers and greater mechanical strength than PNIPAAM homopolymers. Transparent vinyl and hydroxyl terminated PDMS/PNIPAAM IPNs (PDMS-V and PDMS-OH IPNs, respectively) were successfully synthesized. Transmission electron microscopy images verified the structure of the IPNs. Surface analysis suggested that PNIPAAM was present on the surface as well as in the bulk material. PDMS-OH IPNs generated from a PDMS-OH matrix cured in the presence of solvent had the highest glucose permeability at 10(-7)cm2/s, comparable to that of the native cornea. The LCST phenomenon remained in these materials, although changes were not as abrupt as with pure PNIPAAM. These results suggest that these materials may be further developed as ophthalmic biomaterials or for controlled drug-release applications.

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    Source

    Biomaterials 26:3 2005 Jan pg 233-44

    MeSH

    Acrylic Resins
    Biocompatible Materials
    Diffusion
    Dimethylpolysiloxanes
    Glucose
    Materials Testing
    Nylons
    Ophthalmologic Surgical Procedures
    Osmotic Pressure
    Permeability
    Porosity
    Surface Properties
    Temperature
    Tensile Strength
    Water

    Pub Type(s)

    Comparative Study
    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15262466

    Citation

    TY - JOUR T1 - Glucose permeable poly (dimethyl siloxane) poly (N-isopropyl acrylamide) interpenetrating networks as ophthalmic biomaterials. AU - Liu,L, AU - Sheardown,H, PY - 2004/7/21/pubmed PY - 2005/2/16/medline PY - 2003/Sep/24/received PY - 2004/Feb/4/accepted PY - 2004/7/21/entrez SP - 233 EP - 44 JF - Biomaterials JO - Biomaterials VL - 26 IS - 3 N2 - Poly (dimethyl siloxane) (PDMS) has been widely used as a biomaterial in ophthalmic and other applications due to its good compatibility, high mechanical strength, excellent oxygen permeability and transparency. However, for use as an artificial cornea, contact lens and in other applications, modifications with hydrophilic functional groups or polymers are necessary to improve wettability for tear protein and mucin interactions and to improve glucose permeability for cellular health. Poly (N-isopropyl acrylamide) (PNIPAAM) is a biocompatible and hydrophilic polymer that has been extensively studied on controlled drug release applications due to its lower critical solution temperature (LCST) phenomenon. In the current work, a composite interpenetrating network (IPN) of PDMS and PNIPAAM was formed to generate polymers with oxygen and glucose permeability as well as improved wettability compared to PDMS homopolymers and greater mechanical strength than PNIPAAM homopolymers. Transparent vinyl and hydroxyl terminated PDMS/PNIPAAM IPNs (PDMS-V and PDMS-OH IPNs, respectively) were successfully synthesized. Transmission electron microscopy images verified the structure of the IPNs. Surface analysis suggested that PNIPAAM was present on the surface as well as in the bulk material. PDMS-OH IPNs generated from a PDMS-OH matrix cured in the presence of solvent had the highest glucose permeability at 10(-7)cm2/s, comparable to that of the native cornea. The LCST phenomenon remained in these materials, although changes were not as abrupt as with pure PNIPAAM. These results suggest that these materials may be further developed as ophthalmic biomaterials or for controlled drug-release applications. SN - 0142-9612 UR - https://www.unboundmedicine.com/medline/citation/15262466/Glucose_permeable_poly__dimethyl_siloxane__poly__N_isopropyl_acrylamide__interpenetrating_networks_as_ophthalmic_biomaterials_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0142961204001644 ER -