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High altitude cerebral edema.
High Alt Med Biol. 2004 Summer; 5(2):136-46.HA

Abstract

This review focuses on the epidemiology, clinical description, pathophysiology, treatment, and prevention of high altitude cerebral edema (HACE). HACE is an uncommon and sometimes fatal complication of traveling too high, too fast to high altitudes. HACE is distinguished by disturbances of consciousness that may progress to deep coma, psychiatric changes of varying degree, confusion, and ataxia of gait. It is most often a complication of acute mountain sickness or high altitude pulmonary edema. The current leading theory of its pathophysiology is that HACE is a vasogenic edema; that is, a disruption of the blood-brain barrier, and we review possible mechanisms to explain this. Treatment and prevention of HACE are similar to those for the other altitude illnesses, but with greater emphasis on descent and steroids. We conclude the review with several case histories to illustrate key clinical features of the disorder.

Authors+Show Affiliations

International Society for Mountain Medicine and Colorado Center for Altitude Medicine and Physiology, Ridg-way, Colorado 81432, USA. hackett@hypoxia.netNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15265335

Citation

Hackett, Peter H., and Robert C. Roach. "High Altitude Cerebral Edema." High Altitude Medicine & Biology, vol. 5, no. 2, 2004, pp. 136-46.
Hackett PH, Roach RC. High altitude cerebral edema. High Alt Med Biol. 2004;5(2):136-46.
Hackett, P. H., & Roach, R. C. (2004). High altitude cerebral edema. High Altitude Medicine & Biology, 5(2), 136-46.
Hackett PH, Roach RC. High Altitude Cerebral Edema. High Alt Med Biol. 2004;5(2):136-46. PubMed PMID: 15265335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High altitude cerebral edema. AU - Hackett,Peter H, AU - Roach,Robert C, PY - 2004/7/22/pubmed PY - 2004/10/6/medline PY - 2004/7/22/entrez SP - 136 EP - 46 JF - High altitude medicine & biology JO - High Alt. Med. Biol. VL - 5 IS - 2 N2 - This review focuses on the epidemiology, clinical description, pathophysiology, treatment, and prevention of high altitude cerebral edema (HACE). HACE is an uncommon and sometimes fatal complication of traveling too high, too fast to high altitudes. HACE is distinguished by disturbances of consciousness that may progress to deep coma, psychiatric changes of varying degree, confusion, and ataxia of gait. It is most often a complication of acute mountain sickness or high altitude pulmonary edema. The current leading theory of its pathophysiology is that HACE is a vasogenic edema; that is, a disruption of the blood-brain barrier, and we review possible mechanisms to explain this. Treatment and prevention of HACE are similar to those for the other altitude illnesses, but with greater emphasis on descent and steroids. We conclude the review with several case histories to illustrate key clinical features of the disorder. SN - 1527-0297 UR - https://www.unboundmedicine.com/medline/citation/15265335/full_citation L2 - https://www.liebertpub.com/doi/full/10.1089/1527029041352054?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -