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Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia.
Neurosci Lett. 2004 Aug 05; 366(1):24-8.NL

Abstract

Erythropoietin (EPO) prevents neuronal damage following ischemic, metabolic and excitotoxic stress. Recent studies have shown that EPO plays a significant role in the developing brain. The present study investigates the effect of EPO administration on hypoxic-ischemic brain injury and the possibility that its neuroprotective action may be associated with anti-apoptotic activity. Seven-day-old rats were treated with EPO (2000 U/kg) and subjected to a modified Levine procedure. EPO administration before the hypoxic-ischemic insult significantly reduces the severity of brain damage and improved the short-term functional brain recovery. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling and DNA electrophoresis displayed no evidence of DNA fragmentation in EPO-treated animals. These results suggest that EPO might protect the neonatal rat brain by anti-apoptotic mechanisms.

Authors+Show Affiliations

Department of Physiology and Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. spandou@med.auth.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15265583

Citation

Spandou, Evangelia, et al. "Erythropoietin Prevents Hypoxia/ischemia-induced DNA Fragmentation in an Experimental Model of Perinatal Asphyxia." Neuroscience Letters, vol. 366, no. 1, 2004, pp. 24-8.
Spandou E, Soubasi V, Papoutsopoulou S, et al. Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia. Neurosci Lett. 2004;366(1):24-8.
Spandou, E., Soubasi, V., Papoutsopoulou, S., Karkavelas, G., Simeonidou, C., Kaiki-Astara, A., & Guiba-Tziampiri, O. (2004). Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia. Neuroscience Letters, 366(1), 24-8.
Spandou E, et al. Erythropoietin Prevents Hypoxia/ischemia-induced DNA Fragmentation in an Experimental Model of Perinatal Asphyxia. Neurosci Lett. 2004 Aug 5;366(1):24-8. PubMed PMID: 15265583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia. AU - Spandou,Evangelia, AU - Soubasi,Vassiliki, AU - Papoutsopoulou,Stamatia, AU - Karkavelas,George, AU - Simeonidou,Constantina, AU - Kaiki-Astara,A, AU - Guiba-Tziampiri,Olympia, PY - 2004/01/30/received PY - 2004/04/21/revised PY - 2004/05/05/accepted PY - 2004/7/22/pubmed PY - 2004/8/27/medline PY - 2004/7/22/entrez SP - 24 EP - 8 JF - Neuroscience letters JO - Neurosci Lett VL - 366 IS - 1 N2 - Erythropoietin (EPO) prevents neuronal damage following ischemic, metabolic and excitotoxic stress. Recent studies have shown that EPO plays a significant role in the developing brain. The present study investigates the effect of EPO administration on hypoxic-ischemic brain injury and the possibility that its neuroprotective action may be associated with anti-apoptotic activity. Seven-day-old rats were treated with EPO (2000 U/kg) and subjected to a modified Levine procedure. EPO administration before the hypoxic-ischemic insult significantly reduces the severity of brain damage and improved the short-term functional brain recovery. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling and DNA electrophoresis displayed no evidence of DNA fragmentation in EPO-treated animals. These results suggest that EPO might protect the neonatal rat brain by anti-apoptotic mechanisms. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15265583/Erythropoietin_prevents_hypoxia/ischemia_induced_DNA_fragmentation_in_an_experimental_model_of_perinatal_asphyxia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S030439400400566X DB - PRIME DP - Unbound Medicine ER -