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Basolateral amygdala dopamine receptor antagonism modulates initial reactivity to but not habituation of the acoustic startle response.
Behav Brain Res. 2004 Aug 31; 153(2):383-7.BB

Abstract

Although the basolateral amygdala (BLA) plays a role in the habituation to sensory stimuli, the receptor mechanisms mediating this process remain unclear. In the present study, we investigated the role of BLA dopamine (DA) in the habituation of the acoustic startle response (ASR) with intra-BLA infusions of DA receptor antagonists. Male Long Evans rats were subjected to startle pulses over two consecutive once-daily sessions. Prior to testing on Day 1, separate groups of animals received bilateral intra-BLA infusions of a D1 (SCH 23390: 0, 3.2, 6.4 microg per side) or a D2/D3 (raclopride: 0, 2.5, 5.0 microg per side) receptor antagonist. Animals were retested 24h later (Day 2) without prior drug infusion in order to assess possible treatment effects on within- and between-session habituation of the ASR. As expected, within- and between-session habituation was observed in vehicle-treated controls. Within-session habituation was also seen in SCH 23390- and raclopride-treated animals both on Day 1 as well as 24h later (Day 2). Evidence of between-session habituation was observed in SCH 23390-treated animals. However, compared to vehicle, intra-BLA SCH 23390 or raclopride attenuated the initial startle response on Day 1, but not Day 2. No evidence of between-session habituation was found in raclopride-treated animals, although this probably reflected the attenuated initial response to the startling stimulus on Day 1 rather than a reduced rate of habituation on Day 2. The present study suggests that while BLA DA is not involved in habituation of the ASR, it may mediate the perceived aversive nature of the initially startling stimuli.

Authors+Show Affiliations

Douglas Hospital Research Centre, McGill University, 6875 Boul. LaSalle, Montréal, Que., H4H 1R3, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15265633

Citation

Stevenson, C W., and A Gratton. "Basolateral Amygdala Dopamine Receptor Antagonism Modulates Initial Reactivity to but Not Habituation of the Acoustic Startle Response." Behavioural Brain Research, vol. 153, no. 2, 2004, pp. 383-7.
Stevenson CW, Gratton A. Basolateral amygdala dopamine receptor antagonism modulates initial reactivity to but not habituation of the acoustic startle response. Behav Brain Res. 2004;153(2):383-7.
Stevenson, C. W., & Gratton, A. (2004). Basolateral amygdala dopamine receptor antagonism modulates initial reactivity to but not habituation of the acoustic startle response. Behavioural Brain Research, 153(2), 383-7.
Stevenson CW, Gratton A. Basolateral Amygdala Dopamine Receptor Antagonism Modulates Initial Reactivity to but Not Habituation of the Acoustic Startle Response. Behav Brain Res. 2004 Aug 31;153(2):383-7. PubMed PMID: 15265633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basolateral amygdala dopamine receptor antagonism modulates initial reactivity to but not habituation of the acoustic startle response. AU - Stevenson,C W, AU - Gratton,A, PY - 2003/09/22/received PY - 2003/12/11/revised PY - 2003/12/16/accepted PY - 2004/7/22/pubmed PY - 2004/12/16/medline PY - 2004/7/22/entrez SP - 383 EP - 7 JF - Behavioural brain research JO - Behav. Brain Res. VL - 153 IS - 2 N2 - Although the basolateral amygdala (BLA) plays a role in the habituation to sensory stimuli, the receptor mechanisms mediating this process remain unclear. In the present study, we investigated the role of BLA dopamine (DA) in the habituation of the acoustic startle response (ASR) with intra-BLA infusions of DA receptor antagonists. Male Long Evans rats were subjected to startle pulses over two consecutive once-daily sessions. Prior to testing on Day 1, separate groups of animals received bilateral intra-BLA infusions of a D1 (SCH 23390: 0, 3.2, 6.4 microg per side) or a D2/D3 (raclopride: 0, 2.5, 5.0 microg per side) receptor antagonist. Animals were retested 24h later (Day 2) without prior drug infusion in order to assess possible treatment effects on within- and between-session habituation of the ASR. As expected, within- and between-session habituation was observed in vehicle-treated controls. Within-session habituation was also seen in SCH 23390- and raclopride-treated animals both on Day 1 as well as 24h later (Day 2). Evidence of between-session habituation was observed in SCH 23390-treated animals. However, compared to vehicle, intra-BLA SCH 23390 or raclopride attenuated the initial startle response on Day 1, but not Day 2. No evidence of between-session habituation was found in raclopride-treated animals, although this probably reflected the attenuated initial response to the startling stimulus on Day 1 rather than a reduced rate of habituation on Day 2. The present study suggests that while BLA DA is not involved in habituation of the ASR, it may mediate the perceived aversive nature of the initially startling stimuli. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15265633/Basolateral_amygdala_dopamine_receptor_antagonism_modulates_initial_reactivity_to_but_not_habituation_of_the_acoustic_startle_response_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166432803004832 DB - PRIME DP - Unbound Medicine ER -