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Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
J Natl Cancer Inst 2004; 96(14):1094-8JNCI

Abstract

BACKGROUND

Several studies have reported that the risk of breast cancer decreases with increasing duration of breast-feeding. Whether breast-feeding is associated with a reduced risk of hereditary breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations is currently unknown.

METHODS

We conducted a case-control study of women with deleterious mutations in either the BRCA1 or the BRCA2 gene. Study participants, drawn from an international cohort, were matched on the basis of BRCA mutation (BRCA1 [n = 685] or BRCA2 [n = 280]), year of birth (+/-2 years), and country of residence. The study involved 965 case subjects diagnosed with breast cancer and 965 control subjects who had no history of breast or ovarian cancer. Information on pregnancies and breast-feeding practices was derived from a questionnaire administered to the women during the course of genetic counseling. Conditional logistic regression analyses were used to estimate odds ratios (ORs) for the risk of breast cancer. All statistical tests were two-sided.

RESULTS

Among women with BRCA1 mutations, the mean total duration of breast-feeding was statistically significantly shorter for case subjects than for control subjects (6.0 versus 8.7 months, respectively; mean difference = 2.7 months, 95% confidence interval [CI] = 1.4 to 4.0; P<.001). The total duration of breast-feeding was associated with a reduced risk of breast cancer (for each month of breast-feeding, OR = 0.98, 95% CI = 0.97 to 0.99; P(trend)<.001). Women with BRCA1 mutations who breast-fed for more than 1 year were less likely to have breast cancer than those who never breast-fed (OR = 0.55, 95% CI = 0.38 to 0.80; P =.001), although no such association was seen for BRCA2 (OR = 0.95, 95% CI = 0.56 to 1.59; P =.83).

CONCLUSIONS

Women with deleterious BRCA1 mutations who breast-fed for a cumulative total of more than 1 year had a statistically significantly reduced risk of breast cancer.

Authors+Show Affiliations

Jubileum Institute, Department of Oncology, Lund University Hospital, Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15265971

Citation

Jernström, H, et al. "Breast-feeding and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers." Journal of the National Cancer Institute, vol. 96, no. 14, 2004, pp. 1094-8.
Jernström H, Lubinski J, Lynch HT, et al. Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst. 2004;96(14):1094-8.
Jernström, H., Lubinski, J., Lynch, H. T., Ghadirian, P., Neuhausen, S., Isaacs, C., ... Narod, S. A. (2004). Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute, 96(14), pp. 1094-8.
Jernström H, et al. Breast-feeding and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers. J Natl Cancer Inst. 2004 Jul 21;96(14):1094-8. PubMed PMID: 15265971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. AU - Jernström,H, AU - Lubinski,J, AU - Lynch,H T, AU - Ghadirian,P, AU - Neuhausen,S, AU - Isaacs,C, AU - Weber,B L, AU - Horsman,D, AU - Rosen,B, AU - Foulkes,W D, AU - Friedman,E, AU - Gershoni-Baruch,R, AU - Ainsworth,P, AU - Daly,M, AU - Garber,J, AU - Olsson,H, AU - Sun,P, AU - Narod,S A, PY - 2004/7/22/pubmed PY - 2004/7/31/medline PY - 2004/7/22/entrez SP - 1094 EP - 8 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 96 IS - 14 N2 - BACKGROUND: Several studies have reported that the risk of breast cancer decreases with increasing duration of breast-feeding. Whether breast-feeding is associated with a reduced risk of hereditary breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations is currently unknown. METHODS: We conducted a case-control study of women with deleterious mutations in either the BRCA1 or the BRCA2 gene. Study participants, drawn from an international cohort, were matched on the basis of BRCA mutation (BRCA1 [n = 685] or BRCA2 [n = 280]), year of birth (+/-2 years), and country of residence. The study involved 965 case subjects diagnosed with breast cancer and 965 control subjects who had no history of breast or ovarian cancer. Information on pregnancies and breast-feeding practices was derived from a questionnaire administered to the women during the course of genetic counseling. Conditional logistic regression analyses were used to estimate odds ratios (ORs) for the risk of breast cancer. All statistical tests were two-sided. RESULTS: Among women with BRCA1 mutations, the mean total duration of breast-feeding was statistically significantly shorter for case subjects than for control subjects (6.0 versus 8.7 months, respectively; mean difference = 2.7 months, 95% confidence interval [CI] = 1.4 to 4.0; P<.001). The total duration of breast-feeding was associated with a reduced risk of breast cancer (for each month of breast-feeding, OR = 0.98, 95% CI = 0.97 to 0.99; P(trend)<.001). Women with BRCA1 mutations who breast-fed for more than 1 year were less likely to have breast cancer than those who never breast-fed (OR = 0.55, 95% CI = 0.38 to 0.80; P =.001), although no such association was seen for BRCA2 (OR = 0.95, 95% CI = 0.56 to 1.59; P =.83). CONCLUSIONS: Women with deleterious BRCA1 mutations who breast-fed for a cumulative total of more than 1 year had a statistically significantly reduced risk of breast cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/15265971/Breast_feeding_and_the_risk_of_breast_cancer_in_BRCA1_and_BRCA2_mutation_carriers_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djh211 DB - PRIME DP - Unbound Medicine ER -