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Immunoenhanced enteral nutrition, effect on inflammatory markers in head and neck cancer patients.
Eur J Clin Nutr 2005; 59(1):145-7EJ

Abstract

The aim of our study was to evaluate the effect of enteral nutrition supplemented with arginine in inflammatory markers in surgical head and neck cancer patients. A population of 29 patients with oral and laryngeal cancer were enrolled in a randomized trial. At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplements with arginine (group I, n=14); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II, n=15). The mean age was 61.1+/-10.8 y (five females/24 males). Characteristics of the patients on enrollment were similar for the two groups. Prealbumin and transferrin improved in both groups. c-reactive protein (CRP) levels decreased in both groups, (group I: 134.5+/-62.5 vs 75.3+/-51 mg/dl:P<0.05) and (group II: 103.6+/-62 vs 43.8+/-34.4 mg/dl:P<0.05). Interleukin-6 (IL-6) improved in both groups (group I: 20.35+/-11.2 vs 6.7+/-3.1 pg/ml:P<0.05) and (group II:22.8+/-40 vs 9.9+/-17.7 pg/ml:ns). Tumoral necrosis factor alpha and lymphocytes did not change. In conclusion, both formulas improved IL-6 and CRP levels. Further studies are needed to determine whether type of formula is the key in these patients or genetic background play a main role in inflammatory response.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation Hospital Rio Hortega, Spain. Dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15266308

Citation

de Luis, D A., et al. "Immunoenhanced Enteral Nutrition, Effect On Inflammatory Markers in Head and Neck Cancer Patients." European Journal of Clinical Nutrition, vol. 59, no. 1, 2005, pp. 145-7.
de Luis DA, Arranz M, Aller R, et al. Immunoenhanced enteral nutrition, effect on inflammatory markers in head and neck cancer patients. Eur J Clin Nutr. 2005;59(1):145-7.
de Luis, D. A., Arranz, M., Aller, R., Izaola, O., Cuellar, L., & Terroba, M. C. (2005). Immunoenhanced enteral nutrition, effect on inflammatory markers in head and neck cancer patients. European Journal of Clinical Nutrition, 59(1), pp. 145-7.
de Luis DA, et al. Immunoenhanced Enteral Nutrition, Effect On Inflammatory Markers in Head and Neck Cancer Patients. Eur J Clin Nutr. 2005;59(1):145-7. PubMed PMID: 15266308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoenhanced enteral nutrition, effect on inflammatory markers in head and neck cancer patients. AU - de Luis,D A, AU - Arranz,M, AU - Aller,R, AU - Izaola,O, AU - Cuellar,L, AU - Terroba,M C, PY - 2004/7/22/pubmed PY - 2005/4/9/medline PY - 2004/7/22/entrez SP - 145 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 1 N2 - The aim of our study was to evaluate the effect of enteral nutrition supplemented with arginine in inflammatory markers in surgical head and neck cancer patients. A population of 29 patients with oral and laryngeal cancer were enrolled in a randomized trial. At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplements with arginine (group I, n=14); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II, n=15). The mean age was 61.1+/-10.8 y (five females/24 males). Characteristics of the patients on enrollment were similar for the two groups. Prealbumin and transferrin improved in both groups. c-reactive protein (CRP) levels decreased in both groups, (group I: 134.5+/-62.5 vs 75.3+/-51 mg/dl:P<0.05) and (group II: 103.6+/-62 vs 43.8+/-34.4 mg/dl:P<0.05). Interleukin-6 (IL-6) improved in both groups (group I: 20.35+/-11.2 vs 6.7+/-3.1 pg/ml:P<0.05) and (group II:22.8+/-40 vs 9.9+/-17.7 pg/ml:ns). Tumoral necrosis factor alpha and lymphocytes did not change. In conclusion, both formulas improved IL-6 and CRP levels. Further studies are needed to determine whether type of formula is the key in these patients or genetic background play a main role in inflammatory response. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15266308/Immunoenhanced_enteral_nutrition_effect_on_inflammatory_markers_in_head_and_neck_cancer_patients_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602034 DB - PRIME DP - Unbound Medicine ER -