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[Efficacy and safety of arbidol in treatment of naturally acquired influenza].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Jun; 26(3):289-93.ZY

Abstract

OBJECTIVE

To evaluate the efficacy and safety of Arbidol in the treatment of naturally acquired influenza.

METHODS

A randomized, double-blinded, placebo controlled trial was conducted. Subjects were enrolled. The inclusion criteria included: aged 18 to 65 years, presented within 36 hours of onset of influenza symptoms; and had documented temperature of 37.8 degrees C or higher during an influenza outbreak in the community. Individuals were randomly divided Arbidol group (200 mg three times daily for 5 days) or placebo group.

RESULTS

Totally 232 individuals were recruited and received medication and follow-up. All of them were qualified to be analyzed for safety as intent-to-treat population (ITT) (113 Arbidol, 109 placebo). Twenty-two (9.48%) were during follow-up or refused to continue the trial, and 210 completed as schecule and identified as PP population (102 Arbidol, 108 placebo). Totally 125 individuals were identified as influenza-infected through laboratory test, which was defined as PPi population (59 Arbidol, 66 placebo). In PPi population, the cumulative alleviation proportion of Arbidol group was significantly higher than that of placebo group. The median duration of illness was 72.0 hours (95% confident interval (CI) 66.00-78.00 hours) in Arbidol group and 96.0 hours (95% CI 87.46-104.54 hours) in placebo group. The median area under the curve (AUC) of decreased total score were significantly higher in Arbidol group than in placebo group, which were 780.00 and 684.00 score-hours respectively. For PP population, similar results were seen. Adverse events reported were similar in Arbidol group and in placebo group. The main adverse events were gastrointestial symptoms and increased transaminase.

CONCLUSION

Arbidol was effective and well tolerated in the treatment of early naturally acquired influenza.

Authors+Show Affiliations

Wang MZ
Department of Respiratory Disease, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. mengzhaowang@yahoo.com
Cai BQ
No affiliation info available
Li LY
No affiliation info available
Lin JT
No affiliation info available
Su N
No affiliation info available
Yu HX
No affiliation info available
Gao H
No affiliation info available
Zhao JZ
No affiliation info available
Liu L
No affiliation info available

MeSH

AdolescentAdultAgedAntiviral AgentsDouble-Blind MethodFemaleFollow-Up StudiesHumansIndolesInfluenza, HumanMaleMiddle Aged

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

chi

PubMed ID

15266832

Citation

Wang, Meng-zhao, et al. "[Efficacy and Safety of Arbidol in Treatment of Naturally Acquired Influenza]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 26, no. 3, 2004, pp. 289-93.
Wang MZ, Cai BQ, Li LY, et al. [Efficacy and safety of arbidol in treatment of naturally acquired influenza]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(3):289-93.
Wang, M. Z., Cai, B. Q., Li, L. Y., Lin, J. T., Su, N., Yu, H. X., Gao, H., Zhao, J. Z., & Liu, L. (2004). [Efficacy and safety of arbidol in treatment of naturally acquired influenza]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 26(3), 289-93.
Wang MZ, et al. [Efficacy and Safety of Arbidol in Treatment of Naturally Acquired Influenza]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(3):289-93. PubMed PMID: 15266832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Efficacy and safety of arbidol in treatment of naturally acquired influenza]. AU - Wang,Meng-zhao, AU - Cai,Bai-qiang, AU - Li,Long-yun, AU - Lin,Jiang-tao, AU - Su,Nan, AU - Yu,Hong-xia, AU - Gao,He, AU - Zhao,Jian-zhong, AU - Liu,Li, PY - 2004/7/23/pubmed PY - 2004/8/25/medline PY - 2004/7/23/entrez SP - 289 EP - 93 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 26 IS - 3 N2 - OBJECTIVE: To evaluate the efficacy and safety of Arbidol in the treatment of naturally acquired influenza. METHODS: A randomized, double-blinded, placebo controlled trial was conducted. Subjects were enrolled. The inclusion criteria included: aged 18 to 65 years, presented within 36 hours of onset of influenza symptoms; and had documented temperature of 37.8 degrees C or higher during an influenza outbreak in the community. Individuals were randomly divided Arbidol group (200 mg three times daily for 5 days) or placebo group. RESULTS: Totally 232 individuals were recruited and received medication and follow-up. All of them were qualified to be analyzed for safety as intent-to-treat population (ITT) (113 Arbidol, 109 placebo). Twenty-two (9.48%) were during follow-up or refused to continue the trial, and 210 completed as schecule and identified as PP population (102 Arbidol, 108 placebo). Totally 125 individuals were identified as influenza-infected through laboratory test, which was defined as PPi population (59 Arbidol, 66 placebo). In PPi population, the cumulative alleviation proportion of Arbidol group was significantly higher than that of placebo group. The median duration of illness was 72.0 hours (95% confident interval (CI) 66.00-78.00 hours) in Arbidol group and 96.0 hours (95% CI 87.46-104.54 hours) in placebo group. The median area under the curve (AUC) of decreased total score were significantly higher in Arbidol group than in placebo group, which were 780.00 and 684.00 score-hours respectively. For PP population, similar results were seen. Adverse events reported were similar in Arbidol group and in placebo group. The main adverse events were gastrointestial symptoms and increased transaminase. CONCLUSION: Arbidol was effective and well tolerated in the treatment of early naturally acquired influenza. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/15266832/[Efficacy_and_safety_of_arbidol_in_treatment_of_naturally_acquired_influenza]_ DB - PRIME DP - Unbound Medicine ER -