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A comparative clinico-pathological study of single dose ROM in paucibacillary leprosy patients with 1-3 skin lesions.
Indian J Lepr. 2003 Jul-Sep; 75(3):209-17.IJ

Abstract

A controlled clinical and histopathological study was carried out to compare the efficacy of a combination of rifampicin 600 mg plus ofloxacin 400 mg plus minocycline 100 mg (ROM) administered as a single dose with that of standard WHO/MDT-PB six months' regimen with regard to resolution of lesion clinically and histopathologically. Skin biopsy was performed at the intake and at 6 months. The study subjects were 32 previously untreated, smear-negative patients, without nerve trunk involvement and having 1-3 skin lesions. The results were analyzed for mean clinical score for marked, moderate and no improvement and mean histopathological score was graded as active, resolving and complete resolution, according to granuloma fraction at the end of 6 months. Marked clinical improvement was seen in 25% and 12%, moderate improvement in 50% and 56% patients treated with ROM and standard regimens respectively. Histopathologically, activity was seen in 62.5% and 43.7% and resolution of granuloma in 25% and 31.2% in the ROM and standard regimens respectively. Both the regimens were equally efficacious in the reduction of clinical score and granuloma fraction. No adverse drug reactions or reversal reactions were seen during the study period in both the groups.

Authors+Show Affiliations

Department of Dermatology, Venerology and Leprosy, Lokmanya Tilak Municipal Medical College, Mumbai 400022.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15267190

Citation

Deshmukh, A R., et al. "A Comparative Clinico-pathological Study of Single Dose ROM in Paucibacillary Leprosy Patients With 1-3 Skin Lesions." Indian Journal of Leprosy, vol. 75, no. 3, 2003, pp. 209-17.
Deshmukh AR, Dhurat RS, Jerajani HR, et al. A comparative clinico-pathological study of single dose ROM in paucibacillary leprosy patients with 1-3 skin lesions. Indian J Lepr. 2003;75(3):209-17.
Deshmukh, A. R., Dhurat, R. S., Jerajani, H. R., & Jerajani, U. R. (2003). A comparative clinico-pathological study of single dose ROM in paucibacillary leprosy patients with 1-3 skin lesions. Indian Journal of Leprosy, 75(3), 209-17.
Deshmukh AR, et al. A Comparative Clinico-pathological Study of Single Dose ROM in Paucibacillary Leprosy Patients With 1-3 Skin Lesions. Indian J Lepr. 2003 Jul-Sep;75(3):209-17. PubMed PMID: 15267190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative clinico-pathological study of single dose ROM in paucibacillary leprosy patients with 1-3 skin lesions. AU - Deshmukh,A R, AU - Dhurat,R S, AU - Jerajani,H R, AU - Jerajani,U R, PY - 2004/7/23/pubmed PY - 2004/8/4/medline PY - 2004/7/23/entrez SP - 209 EP - 17 JF - Indian journal of leprosy JO - Indian J Lepr VL - 75 IS - 3 N2 - A controlled clinical and histopathological study was carried out to compare the efficacy of a combination of rifampicin 600 mg plus ofloxacin 400 mg plus minocycline 100 mg (ROM) administered as a single dose with that of standard WHO/MDT-PB six months' regimen with regard to resolution of lesion clinically and histopathologically. Skin biopsy was performed at the intake and at 6 months. The study subjects were 32 previously untreated, smear-negative patients, without nerve trunk involvement and having 1-3 skin lesions. The results were analyzed for mean clinical score for marked, moderate and no improvement and mean histopathological score was graded as active, resolving and complete resolution, according to granuloma fraction at the end of 6 months. Marked clinical improvement was seen in 25% and 12%, moderate improvement in 50% and 56% patients treated with ROM and standard regimens respectively. Histopathologically, activity was seen in 62.5% and 43.7% and resolution of granuloma in 25% and 31.2% in the ROM and standard regimens respectively. Both the regimens were equally efficacious in the reduction of clinical score and granuloma fraction. No adverse drug reactions or reversal reactions were seen during the study period in both the groups. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/15267190/A_comparative_clinico_pathological_study_of_single_dose_ROM_in_paucibacillary_leprosy_patients_with_1_3_skin_lesions_ L2 - https://www.diseaseinfosearch.org/result/8733 DB - PRIME DP - Unbound Medicine ER -