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Development of brain infarct volume as assessed by magnetic resonance imaging (MRI): follow-up of diffusion-weighted MRI lesions.
J Magn Reson Imaging. 2004 Aug; 20(2):201-7.JM

Abstract

PURPOSE

To investigate the development of ischemic brain lesions, as present in the acute stroke phase, by diffusion-weighted magnetic resonance imaging (DWI), and in the subacute and chronic phases until up to four months after stroke, in fluid-attenuated inversion recovery (FLAIR)- and T2-weighted (T2W) magnetic resonance (MR) images.

MATERIALS AND METHODS

Twelve consecutive patients with their first middle cerebral artery (MCA) infarction were included. Lesion volumes were assessed on T2W images recorded with a turbo spin echo (TSE) and on images recorded with the FLAIR sequence on average on day 8 and after about four months. They were compared with acute lesion volumes in perfusion and DWI images taken within 24 hours of stroke onset.

RESULTS

On day 8, lesion volumes in images obtained with FLAIR exceeded the acute infarct volumes in DWI. The chronic lesion volumes were almost identical in T2W and FLAIR images but significantly reduced compared with the acute DWI lesions. The lesion volumes assessed on DWI images correlated highly with the lesions in the images obtained with TSE or FLAIR, as did the lesions in the images obtained with FLAIR and TSE. The secondary lesion shrinkage was accompanied by ventricular enlargement and perilesional sulcal widening, as most clearly visible in the images obtained with FLAIR.

CONCLUSION

Our results show that the acute DWI lesions are highly predictive for the infarct lesion in the chronic stage after stroke despite a dynamic lesion evolution most evident in MR images obtained with FLAIR.

Authors+Show Affiliations

Department of Neurology, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15269944

Citation

Ritzl, Afra, et al. "Development of Brain Infarct Volume as Assessed By Magnetic Resonance Imaging (MRI): Follow-up of Diffusion-weighted MRI Lesions." Journal of Magnetic Resonance Imaging : JMRI, vol. 20, no. 2, 2004, pp. 201-7.
Ritzl A, Meisel S, Wittsack HJ, et al. Development of brain infarct volume as assessed by magnetic resonance imaging (MRI): follow-up of diffusion-weighted MRI lesions. J Magn Reson Imaging. 2004;20(2):201-7.
Ritzl, A., Meisel, S., Wittsack, H. J., Fink, G. R., Siebler, M., Mödder, U., & Seitz, R. J. (2004). Development of brain infarct volume as assessed by magnetic resonance imaging (MRI): follow-up of diffusion-weighted MRI lesions. Journal of Magnetic Resonance Imaging : JMRI, 20(2), 201-7.
Ritzl A, et al. Development of Brain Infarct Volume as Assessed By Magnetic Resonance Imaging (MRI): Follow-up of Diffusion-weighted MRI Lesions. J Magn Reson Imaging. 2004;20(2):201-7. PubMed PMID: 15269944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of brain infarct volume as assessed by magnetic resonance imaging (MRI): follow-up of diffusion-weighted MRI lesions. AU - Ritzl,Afra, AU - Meisel,Stephanie, AU - Wittsack,Hans-Jörg, AU - Fink,Gereon R, AU - Siebler,Mario, AU - Mödder,Ulrich, AU - Seitz,Rüdiger J, PY - 2004/7/23/pubmed PY - 2004/12/16/medline PY - 2004/7/23/entrez SP - 201 EP - 7 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 20 IS - 2 N2 - PURPOSE: To investigate the development of ischemic brain lesions, as present in the acute stroke phase, by diffusion-weighted magnetic resonance imaging (DWI), and in the subacute and chronic phases until up to four months after stroke, in fluid-attenuated inversion recovery (FLAIR)- and T2-weighted (T2W) magnetic resonance (MR) images. MATERIALS AND METHODS: Twelve consecutive patients with their first middle cerebral artery (MCA) infarction were included. Lesion volumes were assessed on T2W images recorded with a turbo spin echo (TSE) and on images recorded with the FLAIR sequence on average on day 8 and after about four months. They were compared with acute lesion volumes in perfusion and DWI images taken within 24 hours of stroke onset. RESULTS: On day 8, lesion volumes in images obtained with FLAIR exceeded the acute infarct volumes in DWI. The chronic lesion volumes were almost identical in T2W and FLAIR images but significantly reduced compared with the acute DWI lesions. The lesion volumes assessed on DWI images correlated highly with the lesions in the images obtained with TSE or FLAIR, as did the lesions in the images obtained with FLAIR and TSE. The secondary lesion shrinkage was accompanied by ventricular enlargement and perilesional sulcal widening, as most clearly visible in the images obtained with FLAIR. CONCLUSION: Our results show that the acute DWI lesions are highly predictive for the infarct lesion in the chronic stage after stroke despite a dynamic lesion evolution most evident in MR images obtained with FLAIR. SN - 1053-1807 UR - https://www.unboundmedicine.com/medline/citation/15269944/Development_of_brain_infarct_volume_as_assessed_by_magnetic_resonance_imaging__MRI_:_follow_up_of_diffusion_weighted_MRI_lesions_ L2 - https://doi.org/10.1002/jmri.20096 DB - PRIME DP - Unbound Medicine ER -