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Xanthogranulomatous funiculitis and orchiepididymitis: report of 2 cases with immunohistochemical study and literature review.
Arch Pathol Lab Med. 2004 Aug; 128(8):911-4.AP

Abstract

Two patients with xanthogranulomatous inflammation are described, one with involvement of the spermatic cord and the other with 1 testicle and epididymis affected. To our knowledge, only 12 cases of xanthogranulomatous orchiepididymitis have been reported previously, one of which also presented a xanthogranulomatous funiculitis. Clinically, our patients presented with spermatic cord enlargement (case 1) and chronic orchitis that did not respond to treatment with antibiotics (case 2). Histopathologically, both cases showed extensive xanthogranulomatous inflammation with numerous foamy macrophages that were associated with colonies of microorganisms suggestive of actinomyces in case 1. Additionally, Escherichia coli was cultured from the surgical specimen of case 2. The possible underlying pathology may be diabetes in case 1 and phlebitis associated with chronic orchitis in case 2. Differential diagnoses with other lesions that are rich in macrophages, such as malakoplakia, and those testicular neoplasms without serologic tumor markers are discussed.

Authors+Show Affiliations

Department of Pathology, La Paz Hospital, Spain. mnistal.hulp@salud.madrid.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15270607

Citation

Nistal, Manuel, et al. "Xanthogranulomatous Funiculitis and Orchiepididymitis: Report of 2 Cases With Immunohistochemical Study and Literature Review." Archives of Pathology & Laboratory Medicine, vol. 128, no. 8, 2004, pp. 911-4.
Nistal M, Gonzalez-Peramato P, Serrano A, et al. Xanthogranulomatous funiculitis and orchiepididymitis: report of 2 cases with immunohistochemical study and literature review. Arch Pathol Lab Med. 2004;128(8):911-4.
Nistal, M., Gonzalez-Peramato, P., Serrano, A., & Regadera, J. (2004). Xanthogranulomatous funiculitis and orchiepididymitis: report of 2 cases with immunohistochemical study and literature review. Archives of Pathology & Laboratory Medicine, 128(8), 911-4.
Nistal M, et al. Xanthogranulomatous Funiculitis and Orchiepididymitis: Report of 2 Cases With Immunohistochemical Study and Literature Review. Arch Pathol Lab Med. 2004;128(8):911-4. PubMed PMID: 15270607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthogranulomatous funiculitis and orchiepididymitis: report of 2 cases with immunohistochemical study and literature review. AU - Nistal,Manuel, AU - Gonzalez-Peramato,Pilar, AU - Serrano,Alvaro, AU - Regadera,Javier, PY - 2004/7/24/pubmed PY - 2004/12/16/medline PY - 2004/7/24/entrez SP - 911 EP - 4 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 128 IS - 8 N2 - Two patients with xanthogranulomatous inflammation are described, one with involvement of the spermatic cord and the other with 1 testicle and epididymis affected. To our knowledge, only 12 cases of xanthogranulomatous orchiepididymitis have been reported previously, one of which also presented a xanthogranulomatous funiculitis. Clinically, our patients presented with spermatic cord enlargement (case 1) and chronic orchitis that did not respond to treatment with antibiotics (case 2). Histopathologically, both cases showed extensive xanthogranulomatous inflammation with numerous foamy macrophages that were associated with colonies of microorganisms suggestive of actinomyces in case 1. Additionally, Escherichia coli was cultured from the surgical specimen of case 2. The possible underlying pathology may be diabetes in case 1 and phlebitis associated with chronic orchitis in case 2. Differential diagnoses with other lesions that are rich in macrophages, such as malakoplakia, and those testicular neoplasms without serologic tumor markers are discussed. SN - 1543-2165 UR - https://www.unboundmedicine.com/medline/citation/15270607/Xanthogranulomatous_funiculitis_and_orchiepididymitis:_report_of_2_cases_with_immunohistochemical_study_and_literature_review_ L2 - https://meridian.allenpress.com/aplm/article-lookup/doi/10.1043/1543-2165(2004)128<911:XFAORO>2.0.CO;2 DB - PRIME DP - Unbound Medicine ER -