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Volatile anesthetics and succinylcholine in cardiac ryanodine receptor defects.
Anesth Analg. 2004 Aug; 99(2):435-7, table of contents.A&A

Abstract

Familial polymorphic (catecholaminergic) ventricular tachycardia is an arrhythmogenic cardiac disorder caused by mutations of the myocardial isoform of the ryanodine receptor gene (RyR2). Mutations of the corresponding gene in the skeletal muscle (RyR1) predispose its carriers to malignant hyperthermia upon use of volatile anesthetics or succinylcholine, which further deteriorate the inherited intracellular calcium release disorder. We report a series of patients with cardiac RyR defects who underwent general anesthesia without complications. Succinylcholine and volatile anesthetics did not have a clinically significant effect on RyR2 defects.

Authors+Show Affiliations

Department of Cardiology, Helsinki University Hospital, PL 340, Haartmaninkatu 4, FIN-00029 HUS, Helsinki, Finland. heikki.swan@helsinki.fiNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15271719

Citation

Swan, Heikki, et al. "Volatile Anesthetics and Succinylcholine in Cardiac Ryanodine Receptor Defects." Anesthesia and Analgesia, vol. 99, no. 2, 2004, 435-7, table of contents.
Swan H, Laitinen PJ, Toivonen L. Volatile anesthetics and succinylcholine in cardiac ryanodine receptor defects. Anesth Analg. 2004;99(2):435-7, table of contents.
Swan, H., Laitinen, P. J., & Toivonen, L. (2004). Volatile anesthetics and succinylcholine in cardiac ryanodine receptor defects. Anesthesia and Analgesia, 99(2), 435-7, table of contents.
Swan H, Laitinen PJ, Toivonen L. Volatile Anesthetics and Succinylcholine in Cardiac Ryanodine Receptor Defects. Anesth Analg. 2004;99(2):435-7, table of contents. PubMed PMID: 15271719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Volatile anesthetics and succinylcholine in cardiac ryanodine receptor defects. AU - Swan,Heikki, AU - Laitinen,Päivi J, AU - Toivonen,Lauri, PY - 2004/7/24/pubmed PY - 2004/8/24/medline PY - 2004/7/24/entrez SP - 435-7, table of contents JF - Anesthesia and analgesia JO - Anesth Analg VL - 99 IS - 2 N2 - Familial polymorphic (catecholaminergic) ventricular tachycardia is an arrhythmogenic cardiac disorder caused by mutations of the myocardial isoform of the ryanodine receptor gene (RyR2). Mutations of the corresponding gene in the skeletal muscle (RyR1) predispose its carriers to malignant hyperthermia upon use of volatile anesthetics or succinylcholine, which further deteriorate the inherited intracellular calcium release disorder. We report a series of patients with cardiac RyR defects who underwent general anesthesia without complications. Succinylcholine and volatile anesthetics did not have a clinically significant effect on RyR2 defects. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/15271719/Volatile_anesthetics_and_succinylcholine_in_cardiac_ryanodine_receptor_defects_ L2 - https://doi.org/10.1213/01.ANE.0000130395.93107.15 DB - PRIME DP - Unbound Medicine ER -