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Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats.
Braz J Med Biol Res. 2004 Aug; 37(8):1205-13.BJ

Abstract

We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue formation models were used to assess the anti-inflammatory activity, and the Hargreaves model of thermal hyperalgesia was used to assess the antinociceptive activity. To investigate the effect of orally or intraperitoneally (ip) administered drugs on cold-induced gastric lesions, single doses were administered before exposing the animals to a freezer (-18 degrees C) for 45 min in individual cages. We also evaluated the gastric lesions induced by multiple doses of the drugs. Diclofenac plus zinc complex had the same anti-inflammatory and antinociceptive effects as diclofenac alone. Gastric lesions induced by a single dose administered per os and ip were reduced in the group treated with zinc-diclofenac when compared to the groups treated with free diclofenac or diclofenac plus zinc acetate. In the multiple dose treatment, the complex induced a lower number of the most severe lesions when compared to free diclofenac and diclofenac plus zinc acetate. In conclusion, the present study demonstrates that the zinc-diclofenac complex may represent an important therapeutic alternative for the treatment of rheumatic and inflammatory conditions, as its use may be associated with a reduced incidence of gastric lesions.

Authors+Show Affiliations

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15273822

Citation

Santos, L H., et al. "Anti-inflammatory, Antinociceptive and Ulcerogenic Activity of a Zinc-diclofenac Complex in Rats." Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas, vol. 37, no. 8, 2004, pp. 1205-13.
Santos LH, Feres CA, Melo FH, et al. Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats. Braz J Med Biol Res. 2004;37(8):1205-13.
Santos, L. H., Feres, C. A., Melo, F. H., Coelho, M. M., Nothenberg, M. S., Oga, S., & Tagliati, C. A. (2004). Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas, 37(8), 1205-13.
Santos LH, et al. Anti-inflammatory, Antinociceptive and Ulcerogenic Activity of a Zinc-diclofenac Complex in Rats. Braz J Med Biol Res. 2004;37(8):1205-13. PubMed PMID: 15273822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats. AU - Santos,L H, AU - Feres,C A O, AU - Melo,F H, AU - Coelho,M M, AU - Nothenberg,M S, AU - Oga,S, AU - Tagliati,C A, Y1 - 2004/07/20/ PY - 2004/7/27/pubmed PY - 2005/4/5/medline PY - 2004/7/27/entrez SP - 1205 EP - 13 JF - Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas JO - Braz J Med Biol Res VL - 37 IS - 8 N2 - We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue formation models were used to assess the anti-inflammatory activity, and the Hargreaves model of thermal hyperalgesia was used to assess the antinociceptive activity. To investigate the effect of orally or intraperitoneally (ip) administered drugs on cold-induced gastric lesions, single doses were administered before exposing the animals to a freezer (-18 degrees C) for 45 min in individual cages. We also evaluated the gastric lesions induced by multiple doses of the drugs. Diclofenac plus zinc complex had the same anti-inflammatory and antinociceptive effects as diclofenac alone. Gastric lesions induced by a single dose administered per os and ip were reduced in the group treated with zinc-diclofenac when compared to the groups treated with free diclofenac or diclofenac plus zinc acetate. In the multiple dose treatment, the complex induced a lower number of the most severe lesions when compared to free diclofenac and diclofenac plus zinc acetate. In conclusion, the present study demonstrates that the zinc-diclofenac complex may represent an important therapeutic alternative for the treatment of rheumatic and inflammatory conditions, as its use may be associated with a reduced incidence of gastric lesions. SN - 0100-879X UR - https://www.unboundmedicine.com/medline/citation/15273822/Anti_inflammatory_antinociceptive_and_ulcerogenic_activity_of_a_zinc_diclofenac_complex_in_rats_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800011&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -