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Dose verification in clinical IMRT prostate incidents.
Int J Radiat Oncol Biol Phys. 2004 Aug 01; 59(5):1540-7.IJ

Abstract

PURPOSE

In view of the need for dose-validation procedures on each individual intensity-modulated radiation therapy (IMRT) plan, dose-verification measurements by film, by ionization chamber, and by polymer gel-MRI dosimetry were performed for a prostate-treatment plan configuration. Treatment planning system (TPS) calculations were evaluated against dose measurements.

METHODS AND MATERIALS

Intensity-modulated radiation therapy (IMRT) treatments were planned on a commercial TPS. Kodak EDR-2 films were used for the verification of two-dimensional (2D) dose distributions at 1 coronal and 5 axial planes in a water-equivalent phantom. Full three-dimensional (3D) dose distributions were measured by use of a novel polymer gel formulation and a 3D magnetic resonance imaging (MRI) readout technique. Calculations were compared against measurements by means of isocontour maps, gamma-index maps (3% dose difference, 3-mm distance to agreement) and dose-volume histograms.

RESULTS

A good agreement was found between film measurements and TPS predictions for points within the 60% isocontour, for all the examined plans (gamma-index <1 for 96% of pixels). Three-dimensional dose distributions obtained with the polymer gel-MRI method were adequately matched with corresponding TPS calculations, for measurements in a gel phantom covering the planning-target volume (PTV).

CONCLUSIONS

Measured 2D and 3D dose distributions suggest that, for the investigated prostate IMRT plan configuration, TPS calculations provide clinically acceptable accuracy.

Authors+Show Affiliations

Sandilos P
Nuclear and Particle Physics Section, Physics Department, University of Athens, Panepistimioupolis, Ilisia, 157 71 Athens, Greece.
Angelopoulos A
No affiliation info available
Baras P
No affiliation info available
Dardoufas K
No affiliation info available
Karaiskos P
No affiliation info available
Kipouros P
No affiliation info available
Kozicki M
No affiliation info available
Rosiak JM
No affiliation info available
Sakelliou L
No affiliation info available
Seimenis I
No affiliation info available
Vlahos L
No affiliation info available

MeSH

HumansMalePhantoms, ImagingRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Conformal

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15275742

Citation

Sandilos, Panagiotis, et al. "Dose Verification in Clinical IMRT Prostate Incidents." International Journal of Radiation Oncology, Biology, Physics, vol. 59, no. 5, 2004, pp. 1540-7.
Sandilos P, Angelopoulos A, Baras P, et al. Dose verification in clinical IMRT prostate incidents. Int J Radiat Oncol Biol Phys. 2004;59(5):1540-7.
Sandilos, P., Angelopoulos, A., Baras, P., Dardoufas, K., Karaiskos, P., Kipouros, P., Kozicki, M., Rosiak, J. M., Sakelliou, L., Seimenis, I., & Vlahos, L. (2004). Dose verification in clinical IMRT prostate incidents. International Journal of Radiation Oncology, Biology, Physics, 59(5), 1540-7.
Sandilos P, et al. Dose Verification in Clinical IMRT Prostate Incidents. Int J Radiat Oncol Biol Phys. 2004 Aug 1;59(5):1540-7. PubMed PMID: 15275742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose verification in clinical IMRT prostate incidents. AU - Sandilos,Panagiotis, AU - Angelopoulos,Angelos, AU - Baras,Panagiotis, AU - Dardoufas,Konstantinos, AU - Karaiskos,Pantelis, AU - Kipouros,Panagiotis, AU - Kozicki,Marek, AU - Rosiak,Janusz M, AU - Sakelliou,Loukas, AU - Seimenis,Ioannis, AU - Vlahos,Lampros, PY - 2003/12/10/received PY - 2004/04/05/revised PY - 2004/04/07/accepted PY - 2004/7/28/pubmed PY - 2004/8/31/medline PY - 2004/7/28/entrez SP - 1540 EP - 7 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 59 IS - 5 N2 - PURPOSE: In view of the need for dose-validation procedures on each individual intensity-modulated radiation therapy (IMRT) plan, dose-verification measurements by film, by ionization chamber, and by polymer gel-MRI dosimetry were performed for a prostate-treatment plan configuration. Treatment planning system (TPS) calculations were evaluated against dose measurements. METHODS AND MATERIALS: Intensity-modulated radiation therapy (IMRT) treatments were planned on a commercial TPS. Kodak EDR-2 films were used for the verification of two-dimensional (2D) dose distributions at 1 coronal and 5 axial planes in a water-equivalent phantom. Full three-dimensional (3D) dose distributions were measured by use of a novel polymer gel formulation and a 3D magnetic resonance imaging (MRI) readout technique. Calculations were compared against measurements by means of isocontour maps, gamma-index maps (3% dose difference, 3-mm distance to agreement) and dose-volume histograms. RESULTS: A good agreement was found between film measurements and TPS predictions for points within the 60% isocontour, for all the examined plans (gamma-index <1 for 96% of pixels). Three-dimensional dose distributions obtained with the polymer gel-MRI method were adequately matched with corresponding TPS calculations, for measurements in a gel phantom covering the planning-target volume (PTV). CONCLUSIONS: Measured 2D and 3D dose distributions suggest that, for the investigated prostate IMRT plan configuration, TPS calculations provide clinically acceptable accuracy. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/15275742/Dose_verification_in_clinical_IMRT_prostate_incidents_ DB - PRIME DP - Unbound Medicine ER -