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Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer's disease.
Brain Res Bull 2004; 64(1):47-51BR

Abstract

Isoprostanes, novel markers of oxidative injury, are generated by the free radical-mediated peroxidation of arachidonic acid (AA). They are thought to be important in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Using gas chromatography-mass spectrometry (GC-MS), we investigated the alteration of urinary F(2)-isoprostanes in AD patients compared to that of healthy subjects. Our results show that the levels of urinary F(2)-isoprostanes, sum of the prostaglandin F(2 alpha) isomer; prostaglandin F(2 alpha) (PGF(2 alpha)), prostaglandin F(2 beta) (PGF(2 beta)), and 8-isoprostaglandin F(2 alpha) (8-isoPGF(2 alpha)), significantly increased in AD patients (P < 0.05). The concentration of urinary 8-isoPGF(2 alpha), one of the biomarkers of oxidative stress, was not significantly different between 34 AD patients and 20 age-matched controls (P > 0.05). The PGF(2 alpha), formed by endoperoxide reductase from PGH(2), was significantly increased in AD patients, when compared with the levels of the normal controls (P < 0.05). The PGF(2 alpha), an enzymatic product of arachidonic acid, may affect the pathogenesis of AD. In addition, urinary F(2)-isoprostanes can play an important role as a biomarker in AD.

Authors+Show Affiliations

Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15275956

Citation

Kim, Kyung Mee, et al. "Increased Urinary F(2)-isoprostanes Levels in the Patients With Alzheimer's Disease." Brain Research Bulletin, vol. 64, no. 1, 2004, pp. 47-51.
Kim KM, Jung BH, Paeng KJ, et al. Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer's disease. Brain Res Bull. 2004;64(1):47-51.
Kim, K. M., Jung, B. H., Paeng, K. J., Kim, I., & Chung, B. C. (2004). Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer's disease. Brain Research Bulletin, 64(1), pp. 47-51.
Kim KM, et al. Increased Urinary F(2)-isoprostanes Levels in the Patients With Alzheimer's Disease. Brain Res Bull. 2004 Jul 30;64(1):47-51. PubMed PMID: 15275956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer's disease. AU - Kim,Kyung Mee, AU - Jung,Byung Hwa, AU - Paeng,Ki-Jung, AU - Kim,Inseong, AU - Chung,Bong Chul, PY - 2004/04/26/received PY - 2004/04/28/accepted PY - 2004/7/28/pubmed PY - 2004/10/16/medline PY - 2004/7/28/entrez SP - 47 EP - 51 JF - Brain research bulletin JO - Brain Res. Bull. VL - 64 IS - 1 N2 - Isoprostanes, novel markers of oxidative injury, are generated by the free radical-mediated peroxidation of arachidonic acid (AA). They are thought to be important in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Using gas chromatography-mass spectrometry (GC-MS), we investigated the alteration of urinary F(2)-isoprostanes in AD patients compared to that of healthy subjects. Our results show that the levels of urinary F(2)-isoprostanes, sum of the prostaglandin F(2 alpha) isomer; prostaglandin F(2 alpha) (PGF(2 alpha)), prostaglandin F(2 beta) (PGF(2 beta)), and 8-isoprostaglandin F(2 alpha) (8-isoPGF(2 alpha)), significantly increased in AD patients (P < 0.05). The concentration of urinary 8-isoPGF(2 alpha), one of the biomarkers of oxidative stress, was not significantly different between 34 AD patients and 20 age-matched controls (P > 0.05). The PGF(2 alpha), formed by endoperoxide reductase from PGH(2), was significantly increased in AD patients, when compared with the levels of the normal controls (P < 0.05). The PGF(2 alpha), an enzymatic product of arachidonic acid, may affect the pathogenesis of AD. In addition, urinary F(2)-isoprostanes can play an important role as a biomarker in AD. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/15275956/Increased_urinary_F_2__isoprostanes_levels_in_the_patients_with_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361923004001236 DB - PRIME DP - Unbound Medicine ER -