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Serum vitamin A concentration and the risk of hip fracture among women 50 to 74 years old in the United States: a prospective analysis of the NHANES I follow-up study.
Am J Med. 2004 Aug 01; 117(3):169-74.AJ

Abstract

BACKGROUND

Recent studies on the association between vitamin A and fracture risk have focused on samples with high vitamin A intake. We analyzed a cohort that was more representative of the overall U.S. population to test the hypothesis that both high and low serum vitamin A concentrations increase the risk of hip fracture.

METHODS

We utilized data on 2799 women who were 50 to 74 years of age from the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. There were 172 incident hip fractures during the 22-year follow-up period. Using Cox regression analysis, we analyzed the relation between baseline serum vitamin A (retinol and retinyl esters) concentration, as a continuous variable and by quintiles, and hip fracture risk.

RESULTS

While there was no linear relation between serum vitamin A concentration and the risk of hip fracture in the multivariate analysis (hazard ratio [HR] per SD increase = 1.0; 95% confidence interval [CI]: 0.9 to 1.2), analysis by quintiles revealed a U-shaped relation between serum vitamin A concentration and hip fracture. Fracture risk was significantly higher among subjects in the lowest (HR = 1.9; 95% CI: 1.1 to 3.3) and highest (HR = 2.1; 95% CI: 1.2 to 3.6) quintiles compared with those in the middle quintiles.

CONCLUSION

Both low and high serum vitamin A concentrations may be associated with an increased risk of hip fracture.

Authors+Show Affiliations

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15276595

Citation

Opotowsky, Alexander R., et al. "Serum Vitamin a Concentration and the Risk of Hip Fracture Among Women 50 to 74 Years Old in the United States: a Prospective Analysis of the NHANES I Follow-up Study." The American Journal of Medicine, vol. 117, no. 3, 2004, pp. 169-74.
Opotowsky AR, Bilezikian JP, NHANES I follow-up study. Serum vitamin A concentration and the risk of hip fracture among women 50 to 74 years old in the United States: a prospective analysis of the NHANES I follow-up study. Am J Med. 2004;117(3):169-74.
Opotowsky, A. R., & Bilezikian, J. P. (2004). Serum vitamin A concentration and the risk of hip fracture among women 50 to 74 years old in the United States: a prospective analysis of the NHANES I follow-up study. The American Journal of Medicine, 117(3), 169-74.
Opotowsky AR, Bilezikian JP, NHANES I follow-up study. Serum Vitamin a Concentration and the Risk of Hip Fracture Among Women 50 to 74 Years Old in the United States: a Prospective Analysis of the NHANES I Follow-up Study. Am J Med. 2004 Aug 1;117(3):169-74. PubMed PMID: 15276595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum vitamin A concentration and the risk of hip fracture among women 50 to 74 years old in the United States: a prospective analysis of the NHANES I follow-up study. AU - Opotowsky,Alexander R, AU - Bilezikian,John P, AU - ,, PY - 2003/07/02/received PY - 2004/02/26/revised PY - 2004/02/26/accepted PY - 2004/7/28/pubmed PY - 2004/8/21/medline PY - 2004/7/28/entrez SP - 169 EP - 74 JF - The American journal of medicine JO - Am. J. Med. VL - 117 IS - 3 N2 - BACKGROUND: Recent studies on the association between vitamin A and fracture risk have focused on samples with high vitamin A intake. We analyzed a cohort that was more representative of the overall U.S. population to test the hypothesis that both high and low serum vitamin A concentrations increase the risk of hip fracture. METHODS: We utilized data on 2799 women who were 50 to 74 years of age from the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. There were 172 incident hip fractures during the 22-year follow-up period. Using Cox regression analysis, we analyzed the relation between baseline serum vitamin A (retinol and retinyl esters) concentration, as a continuous variable and by quintiles, and hip fracture risk. RESULTS: While there was no linear relation between serum vitamin A concentration and the risk of hip fracture in the multivariate analysis (hazard ratio [HR] per SD increase = 1.0; 95% confidence interval [CI]: 0.9 to 1.2), analysis by quintiles revealed a U-shaped relation between serum vitamin A concentration and hip fracture. Fracture risk was significantly higher among subjects in the lowest (HR = 1.9; 95% CI: 1.1 to 3.3) and highest (HR = 2.1; 95% CI: 1.2 to 3.6) quintiles compared with those in the middle quintiles. CONCLUSION: Both low and high serum vitamin A concentrations may be associated with an increased risk of hip fracture. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/15276595/Serum_vitamin_A_concentration_and_the_risk_of_hip_fracture_among_women_50_to_74_years_old_in_the_United_States:_a_prospective_analysis_of_the_NHANES_I_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S000293430400275X DB - PRIME DP - Unbound Medicine ER -