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Olfactory impairment and Parkinson's disease-like symptoms observed in the common marmoset following administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Acta Otolaryngol Suppl. 2004 AugAO

Abstract

OBJECTIVE

Although olfactory disturbance appears to occur in the early stages of Parkinson's disease (PD) in humans, little is known about its mechanism. The aim of this study was to make a PD model using injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset and to discover the mechanism of olfactory disturbance in this animal.

MATERIAL AND METHODS

Olfactory disturbance induced by MPTP in the common marmoset was observed by behavioral, biochemical and immunohistochemical means.

RESULTS

Administration of MPTP caused common marmosets to enter an akinetic state within a few days and to show signs of impaired olfactory function. Biochemical study showed a decrease in dopamine levels, especially in tissue samples from the caudate nucleus and putamen. Immunohistochemical analysis revealed a lack of tyrosine hydroxylase immunoreactivity, not only in the substantia nigra, caudate nucleus and putamen but also in the olfactory tubercle.

CONCLUSION

These results demonstrate that MPTP causes both PD-like symptoms and olfactory disturbance in the common marmoset. The olfactory disturbance observed in these animals may be due to the lack of dopamine in the olfactory tubercle.

Authors+Show Affiliations

Miwa T
Department of Otorhinolaryngology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan. miwataka@orl.m.kanazawa-u.ac.jp
Watanabe A
No affiliation info available
Mitsumoto Y
No affiliation info available
Furukawa M
No affiliation info available
Fukushima N
No affiliation info available
Moriizumi T
No affiliation info available

MeSH

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsCallithrixCorpus StriatumDisease Models, AnimalDopamineDopamine AgentsFemaleImmunohistochemistryMesencephalonOlfaction DisordersParkinson Disease, Secondary

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15277042

Citation

Miwa, Takaki, et al. "Olfactory Impairment and Parkinson's Disease-like Symptoms Observed in the Common Marmoset Following Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine." Acta Oto-laryngologica. Supplementum, 2004, pp. 80-4.
Miwa T, Watanabe A, Mitsumoto Y, et al. Olfactory impairment and Parkinson's disease-like symptoms observed in the common marmoset following administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Acta Otolaryngol Suppl. 2004.
Miwa, T., Watanabe, A., Mitsumoto, Y., Furukawa, M., Fukushima, N., & Moriizumi, T. (2004). Olfactory impairment and Parkinson's disease-like symptoms observed in the common marmoset following administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Acta Oto-laryngologica. Supplementum, (553), 80-4.
Miwa T, et al. Olfactory Impairment and Parkinson's Disease-like Symptoms Observed in the Common Marmoset Following Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Acta Otolaryngol Suppl. 2004;(553)80-4. PubMed PMID: 15277042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory impairment and Parkinson's disease-like symptoms observed in the common marmoset following administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. AU - Miwa,Takaki, AU - Watanabe,Akihito, AU - Mitsumoto,Yasuhide, AU - Furukawa,Mitsuru, AU - Fukushima,Nanae, AU - Moriizumi,Tetsuji, PY - 2004/7/28/pubmed PY - 2005/3/15/medline PY - 2004/7/28/entrez SP - 80 EP - 4 JF - Acta oto-laryngologica. Supplementum JO - Acta Otolaryngol Suppl IS - 553 N2 - OBJECTIVE: Although olfactory disturbance appears to occur in the early stages of Parkinson's disease (PD) in humans, little is known about its mechanism. The aim of this study was to make a PD model using injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset and to discover the mechanism of olfactory disturbance in this animal. MATERIAL AND METHODS: Olfactory disturbance induced by MPTP in the common marmoset was observed by behavioral, biochemical and immunohistochemical means. RESULTS: Administration of MPTP caused common marmosets to enter an akinetic state within a few days and to show signs of impaired olfactory function. Biochemical study showed a decrease in dopamine levels, especially in tissue samples from the caudate nucleus and putamen. Immunohistochemical analysis revealed a lack of tyrosine hydroxylase immunoreactivity, not only in the substantia nigra, caudate nucleus and putamen but also in the olfactory tubercle. CONCLUSION: These results demonstrate that MPTP causes both PD-like symptoms and olfactory disturbance in the common marmoset. The olfactory disturbance observed in these animals may be due to the lack of dopamine in the olfactory tubercle. SN - 0365-5237 UR - https://www.unboundmedicine.com/medline/citation/15277042/Olfactory_impairment_and_Parkinson's_disease_like_symptoms_observed_in_the_common_marmoset_following_administration_of_1_methyl_4_phenyl_1236_tetrahydropyridine_ DB - PRIME DP - Unbound Medicine ER -