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Antioxidant deficiency in cystic fibrosis: when is the right time to take action?

Abstract

BACKGROUND

Little is known about age- and disease-related changes in prooxidant and antioxidant systems in patients with cystic fibrosis (CF).

OBJECTIVE

We investigated changes in antioxidant concentrations and oxidative stress in plasma, buccal mucosal cells (BMCs), and breath condensate in patients with CF in relation to age and disease progression.

DESIGN

We recruited 22 patients with CF as well as 35 healthy control subjects and conducted a cross-sectional study by dividing the participants into 4 age groups (<6 y, 6-11 y, 12-17 y, > or =18 y). We collected fasting blood samples, BMCs, and breath condensate. Carotenoids, alpha-tocopherol, vitamin C, protein carbonyls, thiobarbituric acid-reactive substances, and F(2)alpha-isoprostane were assessed.

RESULTS

In patients with CF, plasma vitamin C concentrations, plasma and BMC alpha-tocopherol concentrations, and forced expiratory volume in 1 s (percentage predicted) decreased significantly with age. Plasma beta-carotene, beta-cryptoxanthin, and total lycopene were significantly lower in patients than in control subjects in all age groups. Furthermore, alpha-tocopherol and vitamin C plasma concentrations as well as alpha-tocopherol concentrations in BMCs were significantly lower in CF patients > or =18 y old, whereas all indicators of oxidative stress assessed were significantly higher than those same indicators in control subjects.

CONCLUSIONS

Adult patients with CF in particular showed distinct vitamin deficits and elevated indicators of oxidative stress in plasma, BMCs, and breath condensate along with a progression of clinical status. We suggest that early in life dietary habits should be improved and that innovative supplementation strategies should be applied to optimize the antioxidant status of patients with CF.

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  • Authors+Show Affiliations

    ,

    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany.

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aging
    Antioxidants
    Ascorbic Acid Deficiency
    Breath Tests
    Case-Control Studies
    Child
    Cholesterol
    Cystic Fibrosis
    Female
    Humans
    Isoprostanes
    Male
    Mouth Mucosa
    Oxidative Stress
    Thiobarbituric Acid Reactive Substances
    Vitamin E Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15277158

    Citation

    Back, Evelyn I., et al. "Antioxidant Deficiency in Cystic Fibrosis: when Is the Right Time to Take Action?" The American Journal of Clinical Nutrition, vol. 80, no. 2, 2004, pp. 374-84.
    Back EI, Frindt C, Nohr D, et al. Antioxidant deficiency in cystic fibrosis: when is the right time to take action? Am J Clin Nutr. 2004;80(2):374-84.
    Back, E. I., Frindt, C., Nohr, D., Frank, J., Ziebach, R., Stern, M., ... Biesalski, H. K. (2004). Antioxidant deficiency in cystic fibrosis: when is the right time to take action? The American Journal of Clinical Nutrition, 80(2), pp. 374-84.
    Back EI, et al. Antioxidant Deficiency in Cystic Fibrosis: when Is the Right Time to Take Action. Am J Clin Nutr. 2004;80(2):374-84. PubMed PMID: 15277158.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant deficiency in cystic fibrosis: when is the right time to take action? AU - Back,Evelyn I, AU - Frindt,Claudia, AU - Nohr,Donatus, AU - Frank,Juergen, AU - Ziebach,Rita, AU - Stern,Martin, AU - Ranke,Michael, AU - Biesalski,Hans K, PY - 2004/7/28/pubmed PY - 2004/9/1/medline PY - 2004/7/28/entrez SP - 374 EP - 84 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 2 N2 - BACKGROUND: Little is known about age- and disease-related changes in prooxidant and antioxidant systems in patients with cystic fibrosis (CF). OBJECTIVE: We investigated changes in antioxidant concentrations and oxidative stress in plasma, buccal mucosal cells (BMCs), and breath condensate in patients with CF in relation to age and disease progression. DESIGN: We recruited 22 patients with CF as well as 35 healthy control subjects and conducted a cross-sectional study by dividing the participants into 4 age groups (<6 y, 6-11 y, 12-17 y, > or =18 y). We collected fasting blood samples, BMCs, and breath condensate. Carotenoids, alpha-tocopherol, vitamin C, protein carbonyls, thiobarbituric acid-reactive substances, and F(2)alpha-isoprostane were assessed. RESULTS: In patients with CF, plasma vitamin C concentrations, plasma and BMC alpha-tocopherol concentrations, and forced expiratory volume in 1 s (percentage predicted) decreased significantly with age. Plasma beta-carotene, beta-cryptoxanthin, and total lycopene were significantly lower in patients than in control subjects in all age groups. Furthermore, alpha-tocopherol and vitamin C plasma concentrations as well as alpha-tocopherol concentrations in BMCs were significantly lower in CF patients > or =18 y old, whereas all indicators of oxidative stress assessed were significantly higher than those same indicators in control subjects. CONCLUSIONS: Adult patients with CF in particular showed distinct vitamin deficits and elevated indicators of oxidative stress in plasma, BMCs, and breath condensate along with a progression of clinical status. We suggest that early in life dietary habits should be improved and that innovative supplementation strategies should be applied to optimize the antioxidant status of patients with CF. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15277158/Antioxidant_deficiency_in_cystic_fibrosis:_when_is_the_right_time_to_take_action L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.2.374 DB - PRIME DP - Unbound Medicine ER -