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Hepatic proteins and nutrition assessment.
J Am Diet Assoc 2004; 104(8):1258-64JA

Abstract

Serum hepatic protein (albumin, transferrin, and prealbumin) levels have historically been linked in clinical practice to nutritional status. This paradigm can be traced to two conventional categories of malnutrition: kwashiorkor and marasmus. Explanations for both of these conditions evolved before knowledge of the inflammatory processes of acute and chronic illness were known. Substantial literature on the inflammatory process and its effects on hepatic protein metabolism has replaced previous reports suggesting that nutritional status and protein intake are the significant correlates with serum hepatic protein levels. Compelling evidence suggests that serum hepatic protein levels correlate with morbidity and mortality. Thus, serum hepatic protein levels are useful indicators of severity of illness. They help identify those who are the most likely to develop malnutrition, even if well nourished prior to trauma or the onset of illness. Furthermore, hepatic protein levels do not accurately measure nutritional repletion. Low serum levels indicate that a patient is very ill and probably requires aggressive and closely monitored medical nutrition therapy.

Authors+Show Affiliations

Coram Health Care, St. Louis, MO, USA. fuhrmanp@coramhc.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15281044

Citation

Fuhrman, M Patricia, et al. "Hepatic Proteins and Nutrition Assessment." Journal of the American Dietetic Association, vol. 104, no. 8, 2004, pp. 1258-64.
Fuhrman MP, Charney P, Mueller CM. Hepatic proteins and nutrition assessment. J Am Diet Assoc. 2004;104(8):1258-64.
Fuhrman, M. P., Charney, P., & Mueller, C. M. (2004). Hepatic proteins and nutrition assessment. Journal of the American Dietetic Association, 104(8), pp. 1258-64.
Fuhrman MP, Charney P, Mueller CM. Hepatic Proteins and Nutrition Assessment. J Am Diet Assoc. 2004;104(8):1258-64. PubMed PMID: 15281044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic proteins and nutrition assessment. AU - Fuhrman,M Patricia, AU - Charney,Pamela, AU - Mueller,Charles M, PY - 2004/7/29/pubmed PY - 2004/9/1/medline PY - 2004/7/29/entrez SP - 1258 EP - 64 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 104 IS - 8 N2 - Serum hepatic protein (albumin, transferrin, and prealbumin) levels have historically been linked in clinical practice to nutritional status. This paradigm can be traced to two conventional categories of malnutrition: kwashiorkor and marasmus. Explanations for both of these conditions evolved before knowledge of the inflammatory processes of acute and chronic illness were known. Substantial literature on the inflammatory process and its effects on hepatic protein metabolism has replaced previous reports suggesting that nutritional status and protein intake are the significant correlates with serum hepatic protein levels. Compelling evidence suggests that serum hepatic protein levels correlate with morbidity and mortality. Thus, serum hepatic protein levels are useful indicators of severity of illness. They help identify those who are the most likely to develop malnutrition, even if well nourished prior to trauma or the onset of illness. Furthermore, hepatic protein levels do not accurately measure nutritional repletion. Low serum levels indicate that a patient is very ill and probably requires aggressive and closely monitored medical nutrition therapy. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/15281044/Hepatic_proteins_and_nutrition_assessment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002822304009162 DB - PRIME DP - Unbound Medicine ER -