Tags

Type your tag names separated by a space and hit enter

Estimation of heritability of atopic dermatitis in Labrador and Golden Retrievers.
Am J Vet Res. 2004 Jul; 65(7):1014-20.AJ

Abstract

OBJECTIVE

To estimate the heritability of atopic dermatitis in Golden and Labrador Retrievers.

ANIMALS

429 dogs related to 13 dogs with atopic dermatitis.

PROCEDURE

Atopic dermatitis was defined on the basis of the type and frequency of clinical signs recorded in the clinical records, and each dog was classified with atopic dermatitis or probable atopic dermatitis or as nonatopic. By use of data from atopic and nonatopic dogs, regression analyses of parental status on offspring status were performed to estimate heritability.

RESULTS

There was no difference in the frequency of atopic dermatitis between sexes or between breeds. There was a marked association between the atopic status of the parent and that of the offspring, particularly for sires. By use of data from 32 litters in which the status of both parents was known and considering only those dogs classified with atopic dermatitis or as nonatopic, the heritability (+/- SE) of atopic dermatitis was estimated to be 0.47 (+/- 0.17).

CONCLUSIONS AND CLINICAL RELEVANCE

Atopic dermatitis has a strong genetic component, and breeding of dogs with clinical signs of atopic dermatitis should be discouraged.

Authors+Show Affiliations

Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15281664

Citation

Shaw, Stephen C., et al. "Estimation of Heritability of Atopic Dermatitis in Labrador and Golden Retrievers." American Journal of Veterinary Research, vol. 65, no. 7, 2004, pp. 1014-20.
Shaw SC, Wood JL, Freeman J, et al. Estimation of heritability of atopic dermatitis in Labrador and Golden Retrievers. Am J Vet Res. 2004;65(7):1014-20.
Shaw, S. C., Wood, J. L., Freeman, J., Littlewood, J. D., & Hannant, D. (2004). Estimation of heritability of atopic dermatitis in Labrador and Golden Retrievers. American Journal of Veterinary Research, 65(7), 1014-20.
Shaw SC, et al. Estimation of Heritability of Atopic Dermatitis in Labrador and Golden Retrievers. Am J Vet Res. 2004;65(7):1014-20. PubMed PMID: 15281664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of heritability of atopic dermatitis in Labrador and Golden Retrievers. AU - Shaw,Stephen C, AU - Wood,James L N, AU - Freeman,Julia, AU - Littlewood,Janet D, AU - Hannant,Duncan, PY - 2004/7/30/pubmed PY - 2004/9/2/medline PY - 2004/7/30/entrez SP - 1014 EP - 20 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 65 IS - 7 N2 - OBJECTIVE: To estimate the heritability of atopic dermatitis in Golden and Labrador Retrievers. ANIMALS: 429 dogs related to 13 dogs with atopic dermatitis. PROCEDURE: Atopic dermatitis was defined on the basis of the type and frequency of clinical signs recorded in the clinical records, and each dog was classified with atopic dermatitis or probable atopic dermatitis or as nonatopic. By use of data from atopic and nonatopic dogs, regression analyses of parental status on offspring status were performed to estimate heritability. RESULTS: There was no difference in the frequency of atopic dermatitis between sexes or between breeds. There was a marked association between the atopic status of the parent and that of the offspring, particularly for sires. By use of data from 32 litters in which the status of both parents was known and considering only those dogs classified with atopic dermatitis or as nonatopic, the heritability (+/- SE) of atopic dermatitis was estimated to be 0.47 (+/- 0.17). CONCLUSIONS AND CLINICAL RELEVANCE: Atopic dermatitis has a strong genetic component, and breeding of dogs with clinical signs of atopic dermatitis should be discouraged. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/15281664/Estimation_of_heritability_of_atopic_dermatitis_in_Labrador_and_Golden_Retrievers L2 - http://avmajournals.avma.org/doi/full/10.2460/ajvr.2004.65.1014?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -