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Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides.
Org Lett. 2004 Aug 05; 6(16):2649-52.OL

Abstract

Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of aryl- and heteroaryl chlorides with potassium aryl- and heteroaryltrifluoroborates have been accomplished with the supporting ligand S-Phos in good to excellent yield. Hindered biaryls and substrates containing a variety of functional groups can be prepared. Suzuki-Miyaura couplings of a 3-pyridyl boron-based nucleophile with aryl- and heteroaryl chlorides proceed in good to very good yield. [reaction: see text]

Authors+Show Affiliations

Barder TE
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Buchwald SL
No affiliation info available

MeSH

BoratesCatalysisHeterocyclic CompoundsHydrocarbons, ChlorinatedLigandsPalladiumPotassium

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15281735

Citation

Barder, Timothy E., and Stephen L. Buchwald. "Efficient Catalyst for the Suzuki-Miyaura Coupling of Potassium Aryl Trifluoroborates With Aryl Chlorides." Organic Letters, vol. 6, no. 16, 2004, pp. 2649-52.
Barder TE, Buchwald SL. Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides. Org Lett. 2004;6(16):2649-52.
Barder, T. E., & Buchwald, S. L. (2004). Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides. Organic Letters, 6(16), 2649-52.
Barder TE, Buchwald SL. Efficient Catalyst for the Suzuki-Miyaura Coupling of Potassium Aryl Trifluoroborates With Aryl Chlorides. Org Lett. 2004 Aug 5;6(16):2649-52. PubMed PMID: 15281735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides. AU - Barder,Timothy E, AU - Buchwald,Stephen L, PY - 2004/7/30/pubmed PY - 2005/3/3/medline PY - 2004/7/30/entrez SP - 2649 EP - 52 JF - Organic letters JO - Org Lett VL - 6 IS - 16 N2 - Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of aryl- and heteroaryl chlorides with potassium aryl- and heteroaryltrifluoroborates have been accomplished with the supporting ligand S-Phos in good to excellent yield. Hindered biaryls and substrates containing a variety of functional groups can be prepared. Suzuki-Miyaura couplings of a 3-pyridyl boron-based nucleophile with aryl- and heteroaryl chlorides proceed in good to very good yield. [reaction: see text] SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/15281735/Efficient_catalyst_for_the_Suzuki_Miyaura_coupling_of_potassium_aryl_trifluoroborates_with_aryl_chlorides_ DB - PRIME DP - Unbound Medicine ER -