Efficient Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to aromatic and aliphatic acyclic nitroalkenes.Org Lett. 2004 Aug 05; 6(16):2829-32.OL
Abstract
An efficient and highly enantioselective (up to 95% ee) Cu-catalyzed method for asymmetric conjugate addition (ACA) of alkylzinc reagents to acyclic disubstituted nitroalkenes is presented. Reactions are typically effected at ambient temperature in the presence of 2 mol % chiral dipeptide phosphine and 1 mol % (CuOTf)(2).C(6)H(6). Nitroalkenes bearing aromatic as well as aliphatic substituents readily undergo asymmetric additions. [reaction: see text]
MeSH
Pub Type(s)
Journal Article
Research Support, U.S. Gov't, P.H.S.
Language
eng
PubMed ID
15281780
Citation
Mampreian, Dawn M., and Amir H. Hoveyda. "Efficient Cu-catalyzed Asymmetric Conjugate Additions of Alkylzinc Reagents to Aromatic and Aliphatic Acyclic Nitroalkenes." Organic Letters, vol. 6, no. 16, 2004, pp. 2829-32.
Mampreian DM, Hoveyda AH. Efficient Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to aromatic and aliphatic acyclic nitroalkenes. Org Lett. 2004;6(16):2829-32.
Mampreian, D. M., & Hoveyda, A. H. (2004). Efficient Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to aromatic and aliphatic acyclic nitroalkenes. Organic Letters, 6(16), 2829-32.
Mampreian DM, Hoveyda AH. Efficient Cu-catalyzed Asymmetric Conjugate Additions of Alkylzinc Reagents to Aromatic and Aliphatic Acyclic Nitroalkenes. Org Lett. 2004 Aug 5;6(16):2829-32. PubMed PMID: 15281780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Efficient Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to aromatic and aliphatic acyclic nitroalkenes.
AU - Mampreian,Dawn M,
AU - Hoveyda,Amir H,
PY - 2004/7/30/pubmed
PY - 2005/3/3/medline
PY - 2004/7/30/entrez
SP - 2829
EP - 32
JF - Organic letters
JO - Org Lett
VL - 6
IS - 16
N2 - An efficient and highly enantioselective (up to 95% ee) Cu-catalyzed method for asymmetric conjugate addition (ACA) of alkylzinc reagents to acyclic disubstituted nitroalkenes is presented. Reactions are typically effected at ambient temperature in the presence of 2 mol % chiral dipeptide phosphine and 1 mol % (CuOTf)(2).C(6)H(6). Nitroalkenes bearing aromatic as well as aliphatic substituents readily undergo asymmetric additions. [reaction: see text]
SN - 1523-7060
UR - https://www.unboundmedicine.com/medline/citation/15281780/Efficient_Cu_catalyzed_asymmetric_conjugate_additions_of_alkylzinc_reagents_to_aromatic_and_aliphatic_acyclic_nitroalkenes_
DB - PRIME
DP - Unbound Medicine
ER -
