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Association of functional thrombin-activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population.
Am J Hematol. 2004 Aug; 76(4):348-52.AJ

Abstract

Our aim was to determine the associations of functional thrombin-activatable fibrinolysis inhibitor (TAFI) levels in plasma with conventional cardiovascular risk factors, sex and age, and possible correlations with other hemostatic factors in a Spanish population. We included 303 individuals from a Spanish population. Hemostatic factors such as von Willebrand Factor, VII ag, VIIIc, XIc, XIIc, APCR, protein S, protein C, antithrombin, fibrinogen, and t-PA antigen were assayed. The functional TAFI assay was based on the activation of plasma TAFI with thrombin-thrombomodulin, and the measure of TAFIa activity on the hippuryl-Arg substrate. There were no statistical differences in mean values of functional TAFI among the various female age groups or among the different male age groups, with or without cardiovascular risk factors. Only women younger than 30 years of age showed lower levels of functional TAFI compared to older women. No differences were found among men of different ages. Adjusted for sex and age, hemostatic factors did not show a correlation with functional TAFI levels in plasma. Women with hypercholesterolemia showed higher levels of TAFI; other conventional cardiovascular risk factors did not modify functional TAFI levels either in men or in women. We also found no correlation of functional TAFI levels related to any other hemostatic factors.

Authors+Show Affiliations

Unit of Haemostasis and Thrombosis, Hospital de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain. msantamaria@hsp.santpau.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15282667

Citation

Santamaría, Amparo, et al. "Association of Functional Thrombin-activatable Fibrinolysis Inhibitor (TAFI) With Conventional Cardiovascular Risk Factors and Its Correlation With Other Hemostatic Factors in a Spanish Population." American Journal of Hematology, vol. 76, no. 4, 2004, pp. 348-52.
Santamaría A, Borrell M, Oliver A, et al. Association of functional thrombin-activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population. Am J Hematol. 2004;76(4):348-52.
Santamaría, A., Borrell, M., Oliver, A., Ortín, R., Forner, R., Coll, I., Mateo, J., Souto, J. C., & Fontcuberta, J. (2004). Association of functional thrombin-activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population. American Journal of Hematology, 76(4), 348-52.
Santamaría A, et al. Association of Functional Thrombin-activatable Fibrinolysis Inhibitor (TAFI) With Conventional Cardiovascular Risk Factors and Its Correlation With Other Hemostatic Factors in a Spanish Population. Am J Hematol. 2004;76(4):348-52. PubMed PMID: 15282667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of functional thrombin-activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population. AU - Santamaría,Amparo, AU - Borrell,Montserrat, AU - Oliver,Arturo, AU - Ortín,Rosa, AU - Forner,Ruth, AU - Coll,Inmaculada, AU - Mateo,Jose, AU - Souto,Juan Carlos, AU - Fontcuberta,Jordi, PY - 2004/7/30/pubmed PY - 2004/9/17/medline PY - 2004/7/30/entrez SP - 348 EP - 52 JF - American journal of hematology JO - Am J Hematol VL - 76 IS - 4 N2 - Our aim was to determine the associations of functional thrombin-activatable fibrinolysis inhibitor (TAFI) levels in plasma with conventional cardiovascular risk factors, sex and age, and possible correlations with other hemostatic factors in a Spanish population. We included 303 individuals from a Spanish population. Hemostatic factors such as von Willebrand Factor, VII ag, VIIIc, XIc, XIIc, APCR, protein S, protein C, antithrombin, fibrinogen, and t-PA antigen were assayed. The functional TAFI assay was based on the activation of plasma TAFI with thrombin-thrombomodulin, and the measure of TAFIa activity on the hippuryl-Arg substrate. There were no statistical differences in mean values of functional TAFI among the various female age groups or among the different male age groups, with or without cardiovascular risk factors. Only women younger than 30 years of age showed lower levels of functional TAFI compared to older women. No differences were found among men of different ages. Adjusted for sex and age, hemostatic factors did not show a correlation with functional TAFI levels in plasma. Women with hypercholesterolemia showed higher levels of TAFI; other conventional cardiovascular risk factors did not modify functional TAFI levels either in men or in women. We also found no correlation of functional TAFI levels related to any other hemostatic factors. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/15282667/Association_of_functional_thrombin_activatable_fibrinolysis_inhibitor__TAFI__with_conventional_cardiovascular_risk_factors_and_its_correlation_with_other_hemostatic_factors_in_a_Spanish_population_ L2 - https://doi.org/10.1002/ajh.20108 DB - PRIME DP - Unbound Medicine ER -