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Cyst fluid analysis for the differential diagnosis of pancreatic cysts.
Diagn Cytopathol. 2004 Aug; 31(2):100-5.DC

Abstract

Pancreatic cystic neoplasms comprise a pathologically heterogeneous group with many shared clinical features. We assessed the reliability of cyst fluid analysis for the differential diagnosis of pancreatic cysts. Cyst fluid was obtained by fine-needle aspiration from 78 pancreatic cysts. The lesions studied consisted of 17 mucinous cystic tumors (MCTs), 13 serous cystadenomas (SCAs), 5 solid pseudopapillary tumors (SPTs), 8 intraductal papillary mucinous tumors (IPMTs), 6 ductal adenocarcinomas (ACAs) with cystic degeneration, and 29 pseudocysts (PCs). Epithelial cells were observed in 27 (81%) of 33 successful aspirates of cystic neoplasms. Cytologic diagnosis was possible in 5 (31%) out of 16 MCTs. Mucicarmine staining was positive in five out of nine MCTs, one out of one ACA, and one out of two IPMTs, but in none of the SCAs, SPTs, or PCs. Cyst fluid carcinoembryonic antigen (CEA) levels of more than 467 ng/mL had a 87% sensitivity and a 98% specificity for detecting MCTs, and amylase levels of more than 479 U/L had a 73% sensitivity and a 90% specificity for detecting PCs. In conclusion, cyst fluid analysis for cytology, mucin staining, CEA, and amylase levels are useful in the differential diagnosis of pancreatic cysts.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University College of Medicine, Liver Research Institute, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15282721

Citation

Ryu, Ji Kon, et al. "Cyst Fluid Analysis for the Differential Diagnosis of Pancreatic Cysts." Diagnostic Cytopathology, vol. 31, no. 2, 2004, pp. 100-5.
Ryu JK, Woo SM, Hwang JH, et al. Cyst fluid analysis for the differential diagnosis of pancreatic cysts. Diagn Cytopathol. 2004;31(2):100-5.
Ryu, J. K., Woo, S. M., Hwang, J. H., Jeong, J. B., Yoon, Y. B., Park, I. A., Han, J. K., & Kim, Y. T. (2004). Cyst fluid analysis for the differential diagnosis of pancreatic cysts. Diagnostic Cytopathology, 31(2), 100-5.
Ryu JK, et al. Cyst Fluid Analysis for the Differential Diagnosis of Pancreatic Cysts. Diagn Cytopathol. 2004;31(2):100-5. PubMed PMID: 15282721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyst fluid analysis for the differential diagnosis of pancreatic cysts. AU - Ryu,Ji Kon, AU - Woo,Sang Myung, AU - Hwang,Jin-Hyeok, AU - Jeong,Ji Bong, AU - Yoon,Yong Bum, AU - Park,In Ae, AU - Han,Joon Koo, AU - Kim,Yong-Tae, PY - 2004/7/30/pubmed PY - 2005/1/20/medline PY - 2004/7/30/entrez SP - 100 EP - 5 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 31 IS - 2 N2 - Pancreatic cystic neoplasms comprise a pathologically heterogeneous group with many shared clinical features. We assessed the reliability of cyst fluid analysis for the differential diagnosis of pancreatic cysts. Cyst fluid was obtained by fine-needle aspiration from 78 pancreatic cysts. The lesions studied consisted of 17 mucinous cystic tumors (MCTs), 13 serous cystadenomas (SCAs), 5 solid pseudopapillary tumors (SPTs), 8 intraductal papillary mucinous tumors (IPMTs), 6 ductal adenocarcinomas (ACAs) with cystic degeneration, and 29 pseudocysts (PCs). Epithelial cells were observed in 27 (81%) of 33 successful aspirates of cystic neoplasms. Cytologic diagnosis was possible in 5 (31%) out of 16 MCTs. Mucicarmine staining was positive in five out of nine MCTs, one out of one ACA, and one out of two IPMTs, but in none of the SCAs, SPTs, or PCs. Cyst fluid carcinoembryonic antigen (CEA) levels of more than 467 ng/mL had a 87% sensitivity and a 98% specificity for detecting MCTs, and amylase levels of more than 479 U/L had a 73% sensitivity and a 90% specificity for detecting PCs. In conclusion, cyst fluid analysis for cytology, mucin staining, CEA, and amylase levels are useful in the differential diagnosis of pancreatic cysts. SN - 8755-1039 UR - https://www.unboundmedicine.com/medline/citation/15282721/Cyst_fluid_analysis_for_the_differential_diagnosis_of_pancreatic_cysts_ L2 - https://doi.org/10.1002/dc.20085 DB - PRIME DP - Unbound Medicine ER -