Tags

Type your tag names separated by a space and hit enter

Case-control study of cancer among US Army veterans exposed to simian virus 40-contaminated adenovirus vaccine.
Am J Epidemiol 2004; 160(4):317-24AJ

Abstract

Simian virus 40 (SV40) was an accidental contaminant of vaccines produced in monkey kidney tissue cultures in the 1950s and early 1960s, including a parenteral adenovirus vaccine given to several hundred thousand US military recruits. Detection of SV40 DNA in tumor tissues by some laboratories suggests that SV40 contributes to human cancers. To determine if entry into US Army service during periods of administration of SV40-contaminated adenovirus vaccine was associated with an increased risk of cancer, the authors conducted a case-control study of cancer occurring in male Army veterans who entered service in 1959-1961. Cases of brain tumors (n = 181), mesothelioma (n = 10), and non-Hodgkin's lymphoma (n = 220) were identified through a Veterans Administration hospital discharge database, as were colon cancer and lung cancer controls (n = 221). Exposure to adenovirus vaccine was assigned on the basis of known periods of adenovirus vaccine administration and dates of Army entry obtained for cancer cases and controls. The odds ratios associated with exposure to SV40-contaminated adenovirus vaccine were 0.81 (95% confidence interval (CI): 0.52, 1.24) for brain tumors, 1.41 (95% CI: 0.39, 5.15) for mesothelioma, and 0.97 (95% CI: 0.65, 1.44) for non-Hodgkin's lymphoma. These findings do not support a role for SV40 in the development of these cancers.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15286016

Citation

Rollison, Dana E M., et al. "Case-control Study of Cancer Among US Army Veterans Exposed to Simian Virus 40-contaminated Adenovirus Vaccine." American Journal of Epidemiology, vol. 160, no. 4, 2004, pp. 317-24.
Rollison DE, Page WF, Crawford H, et al. Case-control study of cancer among US Army veterans exposed to simian virus 40-contaminated adenovirus vaccine. Am J Epidemiol. 2004;160(4):317-24.
Rollison, D. E., Page, W. F., Crawford, H., Gridley, G., Wacholder, S., Martin, J., ... Engels, E. A. (2004). Case-control study of cancer among US Army veterans exposed to simian virus 40-contaminated adenovirus vaccine. American Journal of Epidemiology, 160(4), pp. 317-24.
Rollison DE, et al. Case-control Study of Cancer Among US Army Veterans Exposed to Simian Virus 40-contaminated Adenovirus Vaccine. Am J Epidemiol. 2004 Aug 15;160(4):317-24. PubMed PMID: 15286016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case-control study of cancer among US Army veterans exposed to simian virus 40-contaminated adenovirus vaccine. AU - Rollison,Dana E M, AU - Page,William F, AU - Crawford,Harriet, AU - Gridley,Gloria, AU - Wacholder,Sholom, AU - Martin,Jennifer, AU - Miller,Richard, AU - Engels,Eric A, PY - 2004/8/3/pubmed PY - 2004/9/24/medline PY - 2004/8/3/entrez SP - 317 EP - 24 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 160 IS - 4 N2 - Simian virus 40 (SV40) was an accidental contaminant of vaccines produced in monkey kidney tissue cultures in the 1950s and early 1960s, including a parenteral adenovirus vaccine given to several hundred thousand US military recruits. Detection of SV40 DNA in tumor tissues by some laboratories suggests that SV40 contributes to human cancers. To determine if entry into US Army service during periods of administration of SV40-contaminated adenovirus vaccine was associated with an increased risk of cancer, the authors conducted a case-control study of cancer occurring in male Army veterans who entered service in 1959-1961. Cases of brain tumors (n = 181), mesothelioma (n = 10), and non-Hodgkin's lymphoma (n = 220) were identified through a Veterans Administration hospital discharge database, as were colon cancer and lung cancer controls (n = 221). Exposure to adenovirus vaccine was assigned on the basis of known periods of adenovirus vaccine administration and dates of Army entry obtained for cancer cases and controls. The odds ratios associated with exposure to SV40-contaminated adenovirus vaccine were 0.81 (95% confidence interval (CI): 0.52, 1.24) for brain tumors, 1.41 (95% CI: 0.39, 5.15) for mesothelioma, and 0.97 (95% CI: 0.65, 1.44) for non-Hodgkin's lymphoma. These findings do not support a role for SV40 in the development of these cancers. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15286016/Case_control_study_of_cancer_among_US_Army_veterans_exposed_to_simian_virus_40_contaminated_adenovirus_vaccine_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwh212 DB - PRIME DP - Unbound Medicine ER -