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Epidemiology of childhood tuberculosis in the United States, 1993-2001: the need for continued vigilance.
Pediatrics. 2004 Aug; 114(2):333-41.Ped

Abstract

OBJECTIVE

To describe trends and highlight epidemiologic and clinical characteristics of childhood tuberculosis (TB) in the United States.

METHODS

All verified TB cases reported to the national TB surveillance system from 1993 to 2001 were included. A child was defined as a person younger than 15 years.

RESULTS

A total of 11,480 childhood TB cases were reported. Case rates (TB cases/100,000 population) in all children declined from 2.9 (n = 1663) in 1993 to 1.5 (n = 931) in 2001. Among children, those who were younger than 5 years had the highest rate. California, Texas, and New York accounted for 48% of all childhood TB cases. In 2001, TB case rates were higher for foreign-born (12.2) than US-born children (1.1). Hispanic and non-Hispanic black children accounted for nearly three quarters of all cases. Twenty-four percent of children with TB were foreign-born children, with the largest number originating from Mexico (39.8%), the Philippines (8.6%), and Vietnam (5.7%). Most children had evidence of pulmonary TB disease (78.9%). Among culture-positive cases without previous TB, drug resistance to at least isoniazid was 7.3% and to isoniazid and rifampin was 1.6%. In 1999, 82.9% of children received directly observed therapy for at least part of their treatment and 94.8% completed treatment.

CONCLUSIONS

Although the overall TB case number among children is declining in the United States, certain groups of children (eg, younger children, racial and ethnic minorities, foreign-born) are at higher risk for TB. As the United States moves toward the elimination of TB, future efforts should endeavor to prevent all cases of childhood TB.

Authors+Show Affiliations

National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. lbn9@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15286213

Citation

Nelson, Lisa J., et al. "Epidemiology of Childhood Tuberculosis in the United States, 1993-2001: the Need for Continued Vigilance." Pediatrics, vol. 114, no. 2, 2004, pp. 333-41.
Nelson LJ, Schneider E, Wells CD, et al. Epidemiology of childhood tuberculosis in the United States, 1993-2001: the need for continued vigilance. Pediatrics. 2004;114(2):333-41.
Nelson, L. J., Schneider, E., Wells, C. D., & Moore, M. (2004). Epidemiology of childhood tuberculosis in the United States, 1993-2001: the need for continued vigilance. Pediatrics, 114(2), 333-41.
Nelson LJ, et al. Epidemiology of Childhood Tuberculosis in the United States, 1993-2001: the Need for Continued Vigilance. Pediatrics. 2004;114(2):333-41. PubMed PMID: 15286213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of childhood tuberculosis in the United States, 1993-2001: the need for continued vigilance. AU - Nelson,Lisa J, AU - Schneider,Eileen, AU - Wells,Charles D, AU - Moore,Marisa, PY - 2004/8/3/pubmed PY - 2004/12/28/medline PY - 2004/8/3/entrez SP - 333 EP - 41 JF - Pediatrics JO - Pediatrics VL - 114 IS - 2 N2 - OBJECTIVE: To describe trends and highlight epidemiologic and clinical characteristics of childhood tuberculosis (TB) in the United States. METHODS: All verified TB cases reported to the national TB surveillance system from 1993 to 2001 were included. A child was defined as a person younger than 15 years. RESULTS: A total of 11,480 childhood TB cases were reported. Case rates (TB cases/100,000 population) in all children declined from 2.9 (n = 1663) in 1993 to 1.5 (n = 931) in 2001. Among children, those who were younger than 5 years had the highest rate. California, Texas, and New York accounted for 48% of all childhood TB cases. In 2001, TB case rates were higher for foreign-born (12.2) than US-born children (1.1). Hispanic and non-Hispanic black children accounted for nearly three quarters of all cases. Twenty-four percent of children with TB were foreign-born children, with the largest number originating from Mexico (39.8%), the Philippines (8.6%), and Vietnam (5.7%). Most children had evidence of pulmonary TB disease (78.9%). Among culture-positive cases without previous TB, drug resistance to at least isoniazid was 7.3% and to isoniazid and rifampin was 1.6%. In 1999, 82.9% of children received directly observed therapy for at least part of their treatment and 94.8% completed treatment. CONCLUSIONS: Although the overall TB case number among children is declining in the United States, certain groups of children (eg, younger children, racial and ethnic minorities, foreign-born) are at higher risk for TB. As the United States moves toward the elimination of TB, future efforts should endeavor to prevent all cases of childhood TB. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/15286213/Epidemiology_of_childhood_tuberculosis_in_the_United_States_1993_2001:_the_need_for_continued_vigilance_ L2 - https://publications.aap.org/pediatrics/article-lookup/doi/10.1542/peds.114.2.333 DB - PRIME DP - Unbound Medicine ER -