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Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia.
Dement Geriatr Cogn Disord. 2004; 18(3-4):265-70.DG

Abstract

A large body of evidence supports a role of oxidative stress in Alzheimer disease (AD) and in cerebrovascular disease. A vascular component might be critical in the pathophysiology of AD, but there is a substantial lack of data regarding the simultaneous behavior of peripheral antioxidants and biomarkers of oxidative stress in AD and vascular dementia (VaD). Sixty-three AD patients, 23 VaD patients and 55 controls were included in the study. We measured plasma levels of water-soluble (vitamin C and uric acid) and lipophilic (vitamin E, vitamin A, carotenoids including lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha- and beta-carotene) antioxidant micronutrients as well as levels of biomarkers of lipid peroxidation [malondialdehyde (MDA)] and of protein oxidation [immunoglobulin G (IgG) levels of protein carbonyls and dityrosine] in patients and controls. With the exception of beta-carotene, all antioxidants were lower in demented patients as compared to controls. Furthermore, AD patients showed a significantly higher IgG dityrosine content as compared to controls. AD and VaD patients showed similar plasma levels of plasma antioxidants and MDA as well as a similar IgG content of protein carbonyls and dityrosine. We conclude that, independent of its nature-vascular or degenerative-dementia is associated with the depletion of a large spectrum of antioxidant micronutrients and with increased protein oxidative modification. This might be relevant to the pathophysiology of dementing disorders, particularly in light of the recently suggested importance of the vascular component in AD development.

Authors+Show Affiliations

Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15286458

Citation

Polidori, M Cristina, et al. "Plasma Antioxidant Status, Immunoglobulin G Oxidation and Lipid Peroxidation in Demented Patients: Relevance to Alzheimer Disease and Vascular Dementia." Dementia and Geriatric Cognitive Disorders, vol. 18, no. 3-4, 2004, pp. 265-70.
Polidori MC, Mattioli P, Aldred S, et al. Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord. 2004;18(3-4):265-70.
Polidori, M. C., Mattioli, P., Aldred, S., Cecchetti, R., Stahl, W., Griffiths, H., Senin, U., Sies, H., & Mecocci, P. (2004). Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dementia and Geriatric Cognitive Disorders, 18(3-4), 265-70.
Polidori MC, et al. Plasma Antioxidant Status, Immunoglobulin G Oxidation and Lipid Peroxidation in Demented Patients: Relevance to Alzheimer Disease and Vascular Dementia. Dement Geriatr Cogn Disord. 2004;18(3-4):265-70. PubMed PMID: 15286458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. AU - Polidori,M Cristina, AU - Mattioli,Paola, AU - Aldred,Sarah, AU - Cecchetti,Roberta, AU - Stahl,Wilhelm, AU - Griffiths,Helen, AU - Senin,Umberto, AU - Sies,Helmut, AU - Mecocci,Patrizia, Y1 - 2004/07/29/ PY - 2004/03/05/accepted PY - 2004/8/3/pubmed PY - 2005/2/17/medline PY - 2004/8/3/entrez SP - 265 EP - 70 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 18 IS - 3-4 N2 - A large body of evidence supports a role of oxidative stress in Alzheimer disease (AD) and in cerebrovascular disease. A vascular component might be critical in the pathophysiology of AD, but there is a substantial lack of data regarding the simultaneous behavior of peripheral antioxidants and biomarkers of oxidative stress in AD and vascular dementia (VaD). Sixty-three AD patients, 23 VaD patients and 55 controls were included in the study. We measured plasma levels of water-soluble (vitamin C and uric acid) and lipophilic (vitamin E, vitamin A, carotenoids including lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha- and beta-carotene) antioxidant micronutrients as well as levels of biomarkers of lipid peroxidation [malondialdehyde (MDA)] and of protein oxidation [immunoglobulin G (IgG) levels of protein carbonyls and dityrosine] in patients and controls. With the exception of beta-carotene, all antioxidants were lower in demented patients as compared to controls. Furthermore, AD patients showed a significantly higher IgG dityrosine content as compared to controls. AD and VaD patients showed similar plasma levels of plasma antioxidants and MDA as well as a similar IgG content of protein carbonyls and dityrosine. We conclude that, independent of its nature-vascular or degenerative-dementia is associated with the depletion of a large spectrum of antioxidant micronutrients and with increased protein oxidative modification. This might be relevant to the pathophysiology of dementing disorders, particularly in light of the recently suggested importance of the vascular component in AD development. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/15286458/Plasma_antioxidant_status_immunoglobulin_g_oxidation_and_lipid_peroxidation_in_demented_patients:_relevance_to_Alzheimer_disease_and_vascular_dementia_ L2 - https://www.karger.com?DOI=10.1159/000080027 DB - PRIME DP - Unbound Medicine ER -