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Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States).
Cancer Causes Control 2004; 15(5):493-501CC

Abstract

OBJECTIVE

The purpose of this study was to investigate whether folate intake is associated with risk for incident sporadic colorectal adenoma, and whether the association differs according to methylenetetrahydrofolate reductase (MTHFR) genotypes or is modified by intakes of alcohol or other micronutrients in the folate metabolism pathway.

METHODS

The authors analyzed data from a colonoscopy-based case-control study (n = 177 cases, 228 controls) conducted in North Carolina between 1995 and 1997.

RESULTS

The multivariate-adjusted odds ratio (OR) comparing the highest to lowest tertile of total folate intake was 0.61 (95% confidence interval [CI] 0.35-1.05); for MTHFR C677T polymorphism CT and TT genotypes relative to the CC genotype they were, respectively, 1.09 (CI: 0.71-1.66) and 0.68 (CI: 0.29-1.61); and for heavy drinkers (> 3 drinks/week) compared to non-drinkers it was 1.67 (CI: 1.00-2.81). The multivariate-adjusted ORs comparing the highest to lowest tertile of total folate intake according to those with the MTHFR CC, CT, and TT genotypes, were, respectively, 0.65 (CI: 0.30-1.39), 0.57 (CI: 0.23-1.44), and 0.22 (CI: 0.02-3.19). For those in the lowest tertile of folate intake who drank more than three drinks a week compared to those who were in the highest tertile of folate intake and did not drink alcohol the OR was 6.54 (CI: 1.96-21.80). There was no substantial evidence for interactions of folate with intakes of methionine, vitamins B2, B6, or B12.

CONCLUSIONS

These data are consistent with hypotheses and previous findings that higher folate intake may reduce risk for colorectal neoplasms, perhaps especially among those who consume more alcohol.

Authors+Show Affiliations

Division of General Internal Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15286469

Citation

Boyapati, Sonia M., et al. "Folate Intake, MTHFR C677T Polymorphism, Alcohol Consumption, and Risk for Sporadic Colorectal Adenoma (United States)." Cancer Causes & Control : CCC, vol. 15, no. 5, 2004, pp. 493-501.
Boyapati SM, Bostick RM, McGlynn KA, et al. Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States). Cancer Causes Control. 2004;15(5):493-501.
Boyapati, S. M., Bostick, R. M., McGlynn, K. A., Fina, M. F., Roufail, W. M., Geisinger, K. R., ... Wargovich, M. (2004). Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States). Cancer Causes & Control : CCC, 15(5), pp. 493-501.
Boyapati SM, et al. Folate Intake, MTHFR C677T Polymorphism, Alcohol Consumption, and Risk for Sporadic Colorectal Adenoma (United States). Cancer Causes Control. 2004;15(5):493-501. PubMed PMID: 15286469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States). AU - Boyapati,Sonia M, AU - Bostick,Roberd M, AU - McGlynn,Katherine A, AU - Fina,Michael F, AU - Roufail,Walter M, AU - Geisinger,Kim R, AU - Hebert,James R, AU - Coker,Ann, AU - Wargovich,Michael, PY - 2004/8/3/pubmed PY - 2004/11/17/medline PY - 2004/8/3/entrez SP - 493 EP - 501 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 15 IS - 5 N2 - OBJECTIVE: The purpose of this study was to investigate whether folate intake is associated with risk for incident sporadic colorectal adenoma, and whether the association differs according to methylenetetrahydrofolate reductase (MTHFR) genotypes or is modified by intakes of alcohol or other micronutrients in the folate metabolism pathway. METHODS: The authors analyzed data from a colonoscopy-based case-control study (n = 177 cases, 228 controls) conducted in North Carolina between 1995 and 1997. RESULTS: The multivariate-adjusted odds ratio (OR) comparing the highest to lowest tertile of total folate intake was 0.61 (95% confidence interval [CI] 0.35-1.05); for MTHFR C677T polymorphism CT and TT genotypes relative to the CC genotype they were, respectively, 1.09 (CI: 0.71-1.66) and 0.68 (CI: 0.29-1.61); and for heavy drinkers (> 3 drinks/week) compared to non-drinkers it was 1.67 (CI: 1.00-2.81). The multivariate-adjusted ORs comparing the highest to lowest tertile of total folate intake according to those with the MTHFR CC, CT, and TT genotypes, were, respectively, 0.65 (CI: 0.30-1.39), 0.57 (CI: 0.23-1.44), and 0.22 (CI: 0.02-3.19). For those in the lowest tertile of folate intake who drank more than three drinks a week compared to those who were in the highest tertile of folate intake and did not drink alcohol the OR was 6.54 (CI: 1.96-21.80). There was no substantial evidence for interactions of folate with intakes of methionine, vitamins B2, B6, or B12. CONCLUSIONS: These data are consistent with hypotheses and previous findings that higher folate intake may reduce risk for colorectal neoplasms, perhaps especially among those who consume more alcohol. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/15286469/Folate_intake_MTHFR_C677T_polymorphism_alcohol_consumption_and_risk_for_sporadic_colorectal_adenoma__United_States__ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15286469.ui DB - PRIME DP - Unbound Medicine ER -