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Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress.
Bone Marrow Transplant. 2004 Oct; 34(7):561-71.BM

Abstract

Iron overload is a common acute and long-term event associated with autologous and allogeneic hematopoietic stem cell transplantation (HSCT). In a state of iron excess, free iron becomes available to catalyze the conversion of reactive oxygen species (ROS) intermediates such as superoxide anion (O2*-) and hydrogen peroxide (H2O2) to highly toxic free radicals such as hydroxyl radical (OH*). ROS may help to promote chronic liver disease, sinusoidal obstruction syndrome, idiopathic pneumonia syndrome and bacterial, fungal and other opportunistic infections. Phlebotomy has been effectively and safely used to deplete excess iron stores post-HSCT in thalassemic and other iron-overloaded patients. Intracellular iron levels may also be decreased through pharmacologic chelating agents, while antioxidants such as N-acetylcysteine, glutamine (glutathione precursor) and captopril have been shown to replenish glutathione redox potential and scavenge free radicals. A better understanding of the mechanisms involved in the iron-generated pro-oxidant state associated with HSCT will likely lead to reduced toxicity and improved patient outcomes.

Authors+Show Affiliations

Division of Hematology/Oncology, Hematopoietic Stem Cell Transplant Program, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15286699

Citation

Evens, A M., et al. "Rust and Corrosion in Hematopoietic Stem Cell Transplantation: the Problem of Iron and Oxidative Stress." Bone Marrow Transplantation, vol. 34, no. 7, 2004, pp. 561-71.
Evens AM, Mehta J, Gordon LI. Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress. Bone Marrow Transplant. 2004;34(7):561-71.
Evens, A. M., Mehta, J., & Gordon, L. I. (2004). Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress. Bone Marrow Transplantation, 34(7), 561-71.
Evens AM, Mehta J, Gordon LI. Rust and Corrosion in Hematopoietic Stem Cell Transplantation: the Problem of Iron and Oxidative Stress. Bone Marrow Transplant. 2004;34(7):561-71. PubMed PMID: 15286699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress. AU - Evens,A M, AU - Mehta,J, AU - Gordon,L I, PY - 2004/8/3/pubmed PY - 2005/2/17/medline PY - 2004/8/3/entrez SP - 561 EP - 71 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 34 IS - 7 N2 - Iron overload is a common acute and long-term event associated with autologous and allogeneic hematopoietic stem cell transplantation (HSCT). In a state of iron excess, free iron becomes available to catalyze the conversion of reactive oxygen species (ROS) intermediates such as superoxide anion (O2*-) and hydrogen peroxide (H2O2) to highly toxic free radicals such as hydroxyl radical (OH*). ROS may help to promote chronic liver disease, sinusoidal obstruction syndrome, idiopathic pneumonia syndrome and bacterial, fungal and other opportunistic infections. Phlebotomy has been effectively and safely used to deplete excess iron stores post-HSCT in thalassemic and other iron-overloaded patients. Intracellular iron levels may also be decreased through pharmacologic chelating agents, while antioxidants such as N-acetylcysteine, glutamine (glutathione precursor) and captopril have been shown to replenish glutathione redox potential and scavenge free radicals. A better understanding of the mechanisms involved in the iron-generated pro-oxidant state associated with HSCT will likely lead to reduced toxicity and improved patient outcomes. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/15286699/Rust_and_corrosion_in_hematopoietic_stem_cell_transplantation:_the_problem_of_iron_and_oxidative_stress_ L2 - https://doi.org/10.1038/sj.bmt.1704591 DB - PRIME DP - Unbound Medicine ER -