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The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease.
Neurosci Lett. 2004 Aug 19; 366(3):312-4.NL

Abstract

Chronic local inflammatory reaction involving reactive microglia is one of the major pathological events in Alzheimer's disease (AD). There is growing evidence that the chemokine receptor CCR5 is up-regulated in AD brain and plays a role in the recruitment and accumulation of microglia in senile plaques. A 32-base pair deletion in the CCR5 gene (CCR5-Delta32 mutant allele) confers resistance to HIV-1 infection by preventing expression of the receptor on the cell surface. Several other reports have shown a similar protective effect of CCR5-Delta32 mutation towards certain chronic inflammatory diseases. Given the potential importance of CCR5 in brain inflammation, we hypothesized that individuals carrying the CCR5-Delta32 allele would show a reduced risk of AD. So, we performed a case-control study in 376 Spanish AD patients and 369 healthy controls. The frequency of the CCR5-Delta32 allele in our AD sample was 7.8%, not significantly different from our control sample group (5.8%). The present study indicates that the CCR5-Delta32 allele is not a preventive factor for AD.

Authors+Show Affiliations

Service of Neurology, University Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain. combarro@unican.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15288441

Citation

Combarros, Onofre, et al. "The Chemokine Receptor CCR5-Delta32 Gene Mutation Is Not Protective Against Alzheimer's Disease." Neuroscience Letters, vol. 366, no. 3, 2004, pp. 312-4.
Combarros O, Infante J, Llorca J, et al. The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease. Neurosci Lett. 2004;366(3):312-4.
Combarros, O., Infante, J., Llorca, J., Peña, N., Fernández-Viadero, C., & Berciano, J. (2004). The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease. Neuroscience Letters, 366(3), 312-4.
Combarros O, et al. The Chemokine Receptor CCR5-Delta32 Gene Mutation Is Not Protective Against Alzheimer's Disease. Neurosci Lett. 2004 Aug 19;366(3):312-4. PubMed PMID: 15288441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease. AU - Combarros,Onofre, AU - Infante,Jon, AU - Llorca,Javier, AU - Peña,Nicolás, AU - Fernández-Viadero,Carlos, AU - Berciano,José, PY - 2004/03/15/received PY - 2004/04/28/revised PY - 2004/05/22/accepted PY - 2004/8/4/pubmed PY - 2004/10/9/medline PY - 2004/8/4/entrez SP - 312 EP - 4 JF - Neuroscience letters JO - Neurosci. Lett. VL - 366 IS - 3 N2 - Chronic local inflammatory reaction involving reactive microglia is one of the major pathological events in Alzheimer's disease (AD). There is growing evidence that the chemokine receptor CCR5 is up-regulated in AD brain and plays a role in the recruitment and accumulation of microglia in senile plaques. A 32-base pair deletion in the CCR5 gene (CCR5-Delta32 mutant allele) confers resistance to HIV-1 infection by preventing expression of the receptor on the cell surface. Several other reports have shown a similar protective effect of CCR5-Delta32 mutation towards certain chronic inflammatory diseases. Given the potential importance of CCR5 in brain inflammation, we hypothesized that individuals carrying the CCR5-Delta32 allele would show a reduced risk of AD. So, we performed a case-control study in 376 Spanish AD patients and 369 healthy controls. The frequency of the CCR5-Delta32 allele in our AD sample was 7.8%, not significantly different from our control sample group (5.8%). The present study indicates that the CCR5-Delta32 allele is not a preventive factor for AD. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15288441/The_chemokine_receptor_CCR5_Delta32_gene_mutation_is_not_protective_against_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394004006536 DB - PRIME DP - Unbound Medicine ER -