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Vitamin B12 (cobalamin) deficiency in elderly patients.
CMAJ 2004; 171(3):251-9CMAJ

Abstract

Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.

Authors+Show Affiliations

Department of Internal Medicine, Medical Clinic B, Strasbourg University Hospitals, Strasbourg, France. emmanuel.andres@chru-strasbourg.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15289425

Citation

Andrès, Emmanuel, et al. "Vitamin B12 (cobalamin) Deficiency in Elderly Patients." CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, vol. 171, no. 3, 2004, pp. 251-9.
Andrès E, Loukili NH, Noel E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171(3):251-9.
Andrès, E., Loukili, N. H., Noel, E., Kaltenbach, G., Abdelgheni, M. B., Perrin, A. E., ... Blicklé, J. F. (2004). Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, 171(3), pp. 251-9.
Andrès E, et al. Vitamin B12 (cobalamin) Deficiency in Elderly Patients. CMAJ. 2004 Aug 3;171(3):251-9. PubMed PMID: 15289425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 (cobalamin) deficiency in elderly patients. AU - Andrès,Emmanuel, AU - Loukili,Noureddine Henoun, AU - Noel,Esther, AU - Kaltenbach,Georges, AU - Abdelgheni,Maher Ben, AU - Perrin,Anne Elisabeth, AU - Noblet-Dick,Marie, AU - Maloisel,Frédéric, AU - Schlienger,Jean-Louis, AU - Blicklé,Jean-Frédéric, PY - 2004/8/4/pubmed PY - 2004/9/17/medline PY - 2004/8/4/entrez SP - 251 EP - 9 JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne JO - CMAJ VL - 171 IS - 3 N2 - Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency. SN - 0820-3946 UR - https://www.unboundmedicine.com/medline/citation/15289425/full_citation L2 - http://www.cmaj.ca/cgi/pmidlookup?view=long&pmid=15289425 DB - PRIME DP - Unbound Medicine ER -