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Vitamin B12 (cobalamin) deficiency in elderly patients.

Abstract

Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.

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    • Grapherence [↓85 ↑44]

    Authors+Show Affiliations

    Andrès E
    ,

    Department of Internal Medicine, Medical Clinic B, Strasbourg University Hospitals, Strasbourg, France. emmanuel.andres@chru-strasbourg.fr

    Loukili NH
    ,
    Noel E
    ,
    Kaltenbach G
    ,
    Abdelgheni MB
    ,
    Perrin AE
    ,
    Noblet-Dick M
    ,
    Maloisel F
    ,
    Schlienger JL
    ,
    Blicklé JF

    Source

    MeSH

    Aged
    Geriatric Assessment
    Humans
    Vitamin B 12
    Vitamin B 12 Deficiency

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15289425

    Citation

    Andrès, Emmanuel, et al. "Vitamin B12 (cobalamin) Deficiency in Elderly Patients." CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, vol. 171, no. 3, 2004, pp. 251-9.
    Andrès E, Loukili NH, Noel E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171(3):251-9.
    Andrès, E., Loukili, N. H., Noel, E., Kaltenbach, G., Abdelgheni, M. B., Perrin, A. E., ... Blicklé, J. F. (2004). Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, 171(3), pp. 251-9.
    Andrès E, et al. Vitamin B12 (cobalamin) Deficiency in Elderly Patients. CMAJ. 2004 Aug 3;171(3):251-9. PubMed PMID: 15289425.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin B12 (cobalamin) deficiency in elderly patients. AU - Andrès,Emmanuel, AU - Loukili,Noureddine Henoun, AU - Noel,Esther, AU - Kaltenbach,Georges, AU - Abdelgheni,Maher Ben, AU - Perrin,Anne Elisabeth, AU - Noblet-Dick,Marie, AU - Maloisel,Frédéric, AU - Schlienger,Jean-Louis, AU - Blicklé,Jean-Frédéric, PY - 2004/8/4/pubmed PY - 2004/9/17/medline PY - 2004/8/4/entrez SP - 251 EP - 9 JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne JO - CMAJ VL - 171 IS - 3 N2 - Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency. SN - 0820-3946 UR - https://www.unboundmedicine.com/medline/citation/15289425/full_citation L2 - http://www.cmaj.ca/cgi/pmidlookup?view=long&pmid=15289425 DB - PRIME DP - Unbound Medicine ER -