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The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus.
J Rheumatol. 2004 Aug; 31(8):1551-6.JR

Abstract

OBJECTIVE

To determine the effect of dietary supplementation with omega-3 fish oils with or without copper on disease activity in systemic lupus erythematosus (SLE). Fish oil supplementation has a beneficial effect on murine models of SLE, while exogenous copper can decrease the formation of lupus erythematosus cells in rats with a hydralazine-induced collagen disease.

METHODS

A double blind, double placebo controlled factorial trial was performed on 52 patients with SLE. Patients were randomly assigned to 4 treatment groups. Physiological doses of omega-3 fish oils and copper readily obtainable by dietary means were used. One group received 3 g MaxEPA and 3 mg copper, another 3 g MaxEPA and placebo copper, another 3 mg copper and placebo fish oil, and the fourth group received both placebo capsules. Serial measurements of disease activity using the revised Systemic Lupus Activity Measure (SLAM-R) and peripheral blood samples for routine hematological, biochemical, and immunological indices were taken at baseline, 6, 12, and 24 weeks.

RESULTS

There was a significant decline in SLAM-R score from 6.12 to 4.69 (p < 0.05) in those subjects taking fish oil compared to placebo. No significant effect on SLAM-R was observed in subjects taking copper. Laboratory variables were unaffected by either intervention.

CONCLUSION

In the management of SLE, dietary supplementation with fish oil may be beneficial in modifying symptomatic disease activity.

Authors+Show Affiliations

Northern Ireland Center for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Ulster, Northern Ireland, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15290734

Citation

Duffy, Emeir M., et al. "The Clinical Effect of Dietary Supplementation With Omega-3 Fish Oils And/or Copper in Systemic Lupus Erythematosus." The Journal of Rheumatology, vol. 31, no. 8, 2004, pp. 1551-6.
Duffy EM, Meenagh GK, McMillan SA, et al. The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus. J Rheumatol. 2004;31(8):1551-6.
Duffy, E. M., Meenagh, G. K., McMillan, S. A., Strain, J. J., Hannigan, B. M., & Bell, A. L. (2004). The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus. The Journal of Rheumatology, 31(8), 1551-6.
Duffy EM, et al. The Clinical Effect of Dietary Supplementation With Omega-3 Fish Oils And/or Copper in Systemic Lupus Erythematosus. J Rheumatol. 2004;31(8):1551-6. PubMed PMID: 15290734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus. AU - Duffy,Emeir M, AU - Meenagh,Gary K, AU - McMillan,Stanley A, AU - Strain,John J, AU - Hannigan,Bernadette M, AU - Bell,Aubrey L, PY - 2004/8/4/pubmed PY - 2004/12/16/medline PY - 2004/8/4/entrez SP - 1551 EP - 6 JF - The Journal of rheumatology JO - J Rheumatol VL - 31 IS - 8 N2 - OBJECTIVE: To determine the effect of dietary supplementation with omega-3 fish oils with or without copper on disease activity in systemic lupus erythematosus (SLE). Fish oil supplementation has a beneficial effect on murine models of SLE, while exogenous copper can decrease the formation of lupus erythematosus cells in rats with a hydralazine-induced collagen disease. METHODS: A double blind, double placebo controlled factorial trial was performed on 52 patients with SLE. Patients were randomly assigned to 4 treatment groups. Physiological doses of omega-3 fish oils and copper readily obtainable by dietary means were used. One group received 3 g MaxEPA and 3 mg copper, another 3 g MaxEPA and placebo copper, another 3 mg copper and placebo fish oil, and the fourth group received both placebo capsules. Serial measurements of disease activity using the revised Systemic Lupus Activity Measure (SLAM-R) and peripheral blood samples for routine hematological, biochemical, and immunological indices were taken at baseline, 6, 12, and 24 weeks. RESULTS: There was a significant decline in SLAM-R score from 6.12 to 4.69 (p < 0.05) in those subjects taking fish oil compared to placebo. No significant effect on SLAM-R was observed in subjects taking copper. Laboratory variables were unaffected by either intervention. CONCLUSION: In the management of SLE, dietary supplementation with fish oil may be beneficial in modifying symptomatic disease activity. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/15290734/The_clinical_effect_of_dietary_supplementation_with_omega_3_fish_oils_and/or_copper_in_systemic_lupus_erythematosus_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=15290734 DB - PRIME DP - Unbound Medicine ER -