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Intra-individual variation of irritant threshold and relationship to transepidermal water loss measurement of skin irritation.
Contact Dermatitis. 2004 Jul; 51(1):26-9.CD

Abstract

Irritant susceptibility studies have used either visual assessment or transepidermal water loss (TEWL) to determine subject response. We have developed a visual assessment method which determines subject irritant threshold. We examined the relationship between sodium lauryl sulfate (SLS) irritant threshold and TEWL measurements from normal skin and SLS patch tests. 19 subjects were recruited. The irritant threshold of each subject was measured and TEWL measurements made from the applied SLS patch tests. Individuals with a lower irritant threshold (easily irritated skin) had elevated TEWL levels compared to those with higher thresholds. The irritant threshold test had a low intraindividual variation. This study showed that the 2 methods grouped patients in a similar manner. The variation seen may reflect the different outcomes measured: irritant threshold visually assesses the skin inflammatory response while TEWL measures skin barrier modification.

Authors+Show Affiliations

Contact Dermatitis Clinic, St John's Institute of Dermatology, St Thomas' Hospital, London, UK. harveyandlucie@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

15291829

Citation

Smith, H R., et al. "Intra-individual Variation of Irritant Threshold and Relationship to Transepidermal Water Loss Measurement of Skin Irritation." Contact Dermatitis, vol. 51, no. 1, 2004, pp. 26-9.
Smith HR, Rowson M, Basketter DA, et al. Intra-individual variation of irritant threshold and relationship to transepidermal water loss measurement of skin irritation. Contact Dermatitis. 2004;51(1):26-9.
Smith, H. R., Rowson, M., Basketter, D. A., & McFadden, J. P. (2004). Intra-individual variation of irritant threshold and relationship to transepidermal water loss measurement of skin irritation. Contact Dermatitis, 51(1), 26-9.
Smith HR, et al. Intra-individual Variation of Irritant Threshold and Relationship to Transepidermal Water Loss Measurement of Skin Irritation. Contact Dermatitis. 2004;51(1):26-9. PubMed PMID: 15291829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intra-individual variation of irritant threshold and relationship to transepidermal water loss measurement of skin irritation. AU - Smith,H R, AU - Rowson,M, AU - Basketter,D A, AU - McFadden,J P, PY - 2004/8/5/pubmed PY - 2004/12/16/medline PY - 2004/8/5/entrez SP - 26 EP - 9 JF - Contact dermatitis JO - Contact Dermatitis VL - 51 IS - 1 N2 - Irritant susceptibility studies have used either visual assessment or transepidermal water loss (TEWL) to determine subject response. We have developed a visual assessment method which determines subject irritant threshold. We examined the relationship between sodium lauryl sulfate (SLS) irritant threshold and TEWL measurements from normal skin and SLS patch tests. 19 subjects were recruited. The irritant threshold of each subject was measured and TEWL measurements made from the applied SLS patch tests. Individuals with a lower irritant threshold (easily irritated skin) had elevated TEWL levels compared to those with higher thresholds. The irritant threshold test had a low intraindividual variation. This study showed that the 2 methods grouped patients in a similar manner. The variation seen may reflect the different outcomes measured: irritant threshold visually assesses the skin inflammatory response while TEWL measures skin barrier modification. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/15291829/Intra_individual_variation_of_irritant_threshold_and_relationship_to_transepidermal_water_loss_measurement_of_skin_irritation_ L2 - https://doi.org/10.1111/j.0105-1873.2004.00386.x DB - PRIME DP - Unbound Medicine ER -