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Body fat and fat-free mass and all-cause mortality.
Obes Res 2004; 12(7):1042-9OR

Abstract

OBJECTIVE

To investigate whether the association between BMI and all-cause mortality could be disentangled into opposite effects of body fat and fat-free mass (FFM).

RESEARCH METHODS AND PROCEDURES

All-cause mortality was studied in the Danish follow-up study "Diet, Cancer and Health" with 27,178 men and 29,875 women 50 to 64 years old recruited from 1993 to 1997. By the end of year 2001, the median follow-up was 5.8 years, and 1851 had died. Body composition was assessed by bioelectrical impedance. Cox regression models were used to estimate the relationships among body fat mass index (body fat mass divided by height squared), FFM index (FFM divided by height squared), and mortality. All analyses were adjusted for smoking habits.

RESULTS

Men and women showed similar associations. J-shaped associations were found between body fat mass index and mortality adjusted for FFM and smoking. The mortality rate ratios in the upper part of body fat mass were 1.12 per kg/m2 (95% confidence interval: 1.07, 1.18) in men and 1.06 per kg/m2 (95% confidence interval: 1.02, 1.10) in women. Reversed J-shaped associations were found between FFM index and mortality with a tendency to level off for high values of FFM.

DISCUSSION

Our findings suggest that BMI represents joint but opposite associations of body fat and FFM with mortality. Both high body fat and low FFM are independent predictors of all-cause mortality.

Authors+Show Affiliations

Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. janne@cancer.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15292467

Citation

Bigaard, Janne, et al. "Body Fat and Fat-free Mass and All-cause Mortality." Obesity Research, vol. 12, no. 7, 2004, pp. 1042-9.
Bigaard J, Frederiksen K, Tjønneland A, et al. Body fat and fat-free mass and all-cause mortality. Obes Res. 2004;12(7):1042-9.
Bigaard, J., Frederiksen, K., Tjønneland, A., Thomsen, B. L., Overvad, K., Heitmann, B. L., & Sørensen, T. I. (2004). Body fat and fat-free mass and all-cause mortality. Obesity Research, 12(7), pp. 1042-9.
Bigaard J, et al. Body Fat and Fat-free Mass and All-cause Mortality. Obes Res. 2004;12(7):1042-9. PubMed PMID: 15292467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body fat and fat-free mass and all-cause mortality. AU - Bigaard,Janne, AU - Frederiksen,Kirsten, AU - Tjønneland,Anne, AU - Thomsen,Birthe Lykke, AU - Overvad,Kim, AU - Heitmann,Berit Lillienthal, AU - Sørensen,Thorkild I A, PY - 2004/8/5/pubmed PY - 2004/10/29/medline PY - 2004/8/5/entrez SP - 1042 EP - 9 JF - Obesity research JO - Obes. Res. VL - 12 IS - 7 N2 - OBJECTIVE: To investigate whether the association between BMI and all-cause mortality could be disentangled into opposite effects of body fat and fat-free mass (FFM). RESEARCH METHODS AND PROCEDURES: All-cause mortality was studied in the Danish follow-up study "Diet, Cancer and Health" with 27,178 men and 29,875 women 50 to 64 years old recruited from 1993 to 1997. By the end of year 2001, the median follow-up was 5.8 years, and 1851 had died. Body composition was assessed by bioelectrical impedance. Cox regression models were used to estimate the relationships among body fat mass index (body fat mass divided by height squared), FFM index (FFM divided by height squared), and mortality. All analyses were adjusted for smoking habits. RESULTS: Men and women showed similar associations. J-shaped associations were found between body fat mass index and mortality adjusted for FFM and smoking. The mortality rate ratios in the upper part of body fat mass were 1.12 per kg/m2 (95% confidence interval: 1.07, 1.18) in men and 1.06 per kg/m2 (95% confidence interval: 1.02, 1.10) in women. Reversed J-shaped associations were found between FFM index and mortality with a tendency to level off for high values of FFM. DISCUSSION: Our findings suggest that BMI represents joint but opposite associations of body fat and FFM with mortality. Both high body fat and low FFM are independent predictors of all-cause mortality. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15292467/Body_fat_and_fat_free_mass_and_all_cause_mortality_ L2 - https://doi.org/10.1038/oby.2004.131 DB - PRIME DP - Unbound Medicine ER -