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Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study.
Eur J Cardiovasc Prev Rehabil 2004; 11(4):336-43EJ

Abstract

BACKGROUND

The effects of wine and other alcoholic beverages on coronary heart disease (CHD) have seldom been studied in several countries using a common methodology.

DESIGN

Five-year prospective study conducted among 9750 men (7352 in France and 2398 in Northern Ireland) free of CHD at entry. Outcomes were angina pectoris, myocardial infarction or CHD death.

RESULTS

In all, 90% of subjects in France reported drinking at least once per week, versus 61% in Northern Ireland. In France, after adjusting for other CHD risk factors, subjects in the highest quartile of alcohol consumption had a significantly lower risk of developing angina pectoris relative to non-drinkers. For myocardial infarction and all CHD events, the risk also decreased from the first to the fourth quartile (P for trend=0.02). Conversely, in Northern Ireland, no significant relationship was found between alcohol consumption and the incidence of angina pectoris or all CHD events, although alcohol consumption appeared to decrease the risk for myocardial infarction. Similar findings were obtained when the 5% higher alcohol consumers were excluded from the analysis. Finally, splitting the alcohol consumption into wine, beer and spirits did not improve the relationships, the three types of beverage exerting comparable effects on CHD events.

CONCLUSIONS

Alcohol consumption patterns exert differential effects on CHD risk in middle-aged men from France and Northern Ireland. Further, the amount of alcohol consumption, rather than the type of alcoholic beverage, is related to both angina pectoris and myocardial infarction in France, whereas no relationship was found in Northern Ireland.

Authors+Show Affiliations

INSERM U558, Faculté de Médecine Purpan, Toulouse, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15292768

Citation

Marques-Vidal, Pedro, et al. "Alcohol Consumption and Cardiovascular Disease: Differential Effects in France and Northern Ireland. the PRIME Study." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 11, no. 4, 2004, pp. 336-43.
Marques-Vidal P, Montaye M, Arveiler D, et al. Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study. Eur J Cardiovasc Prev Rehabil. 2004;11(4):336-43.
Marques-Vidal, P., Montaye, M., Arveiler, D., Evans, A., Bingham, A., Ruidavets, J. B., ... Ferrières, J. (2004). Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 11(4), pp. 336-43.
Marques-Vidal P, et al. Alcohol Consumption and Cardiovascular Disease: Differential Effects in France and Northern Ireland. the PRIME Study. Eur J Cardiovasc Prev Rehabil. 2004;11(4):336-43. PubMed PMID: 15292768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study. AU - Marques-Vidal,Pedro, AU - Montaye,Michèle, AU - Arveiler,Dominique, AU - Evans,Alun, AU - Bingham,Annie, AU - Ruidavets,Jean-Bernard, AU - Amouyel,Philippe, AU - Haas,Bernadette, AU - Yarnell,John, AU - Ducimetière,Pierre, AU - Ferrières,Jean, PY - 2004/8/5/pubmed PY - 2006/5/25/medline PY - 2004/8/5/entrez SP - 336 EP - 43 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 11 IS - 4 N2 - BACKGROUND: The effects of wine and other alcoholic beverages on coronary heart disease (CHD) have seldom been studied in several countries using a common methodology. DESIGN: Five-year prospective study conducted among 9750 men (7352 in France and 2398 in Northern Ireland) free of CHD at entry. Outcomes were angina pectoris, myocardial infarction or CHD death. RESULTS: In all, 90% of subjects in France reported drinking at least once per week, versus 61% in Northern Ireland. In France, after adjusting for other CHD risk factors, subjects in the highest quartile of alcohol consumption had a significantly lower risk of developing angina pectoris relative to non-drinkers. For myocardial infarction and all CHD events, the risk also decreased from the first to the fourth quartile (P for trend=0.02). Conversely, in Northern Ireland, no significant relationship was found between alcohol consumption and the incidence of angina pectoris or all CHD events, although alcohol consumption appeared to decrease the risk for myocardial infarction. Similar findings were obtained when the 5% higher alcohol consumers were excluded from the analysis. Finally, splitting the alcohol consumption into wine, beer and spirits did not improve the relationships, the three types of beverage exerting comparable effects on CHD events. CONCLUSIONS: Alcohol consumption patterns exert differential effects on CHD risk in middle-aged men from France and Northern Ireland. Further, the amount of alcohol consumption, rather than the type of alcoholic beverage, is related to both angina pectoris and myocardial infarction in France, whereas no relationship was found in Northern Ireland. SN - 1741-8267 UR - https://www.unboundmedicine.com/medline/citation/15292768/Alcohol_consumption_and_cardiovascular_disease:_differential_effects_in_France_and_Northern_Ireland__The_PRIME_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15292768.ui DB - PRIME DP - Unbound Medicine ER -