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Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study.

Abstract

BACKGROUND

The effects of wine and other alcoholic beverages on coronary heart disease (CHD) have seldom been studied in several countries using a common methodology.

DESIGN

Five-year prospective study conducted among 9750 men (7352 in France and 2398 in Northern Ireland) free of CHD at entry. Outcomes were angina pectoris, myocardial infarction or CHD death.

RESULTS

In all, 90% of subjects in France reported drinking at least once per week, versus 61% in Northern Ireland. In France, after adjusting for other CHD risk factors, subjects in the highest quartile of alcohol consumption had a significantly lower risk of developing angina pectoris relative to non-drinkers. For myocardial infarction and all CHD events, the risk also decreased from the first to the fourth quartile (P for trend=0.02). Conversely, in Northern Ireland, no significant relationship was found between alcohol consumption and the incidence of angina pectoris or all CHD events, although alcohol consumption appeared to decrease the risk for myocardial infarction. Similar findings were obtained when the 5% higher alcohol consumers were excluded from the analysis. Finally, splitting the alcohol consumption into wine, beer and spirits did not improve the relationships, the three types of beverage exerting comparable effects on CHD events.

CONCLUSIONS

Alcohol consumption patterns exert differential effects on CHD risk in middle-aged men from France and Northern Ireland. Further, the amount of alcohol consumption, rather than the type of alcoholic beverage, is related to both angina pectoris and myocardial infarction in France, whereas no relationship was found in Northern Ireland.

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  • Authors+Show Affiliations

    ,

    INSERM U558, Faculté de Médecine Purpan, Toulouse, France.

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    Source

    MeSH

    Alcohol Drinking
    Angina Pectoris
    Biomarkers
    Blood Pressure
    Cardiovascular Diseases
    Cholesterol, LDL
    Follow-Up Studies
    France
    Humans
    Incidence
    Ireland
    Male
    Middle Aged
    Multivariate Analysis
    Myocardial Infarction
    Predictive Value of Tests
    Prospective Studies
    Risk Factors
    Triglycerides

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15292768

    Citation

    Marques-Vidal, Pedro, et al. "Alcohol Consumption and Cardiovascular Disease: Differential Effects in France and Northern Ireland. the PRIME Study." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 11, no. 4, 2004, pp. 336-43.
    Marques-Vidal P, Montaye M, Arveiler D, et al. Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study. Eur J Cardiovasc Prev Rehabil. 2004;11(4):336-43.
    Marques-Vidal, P., Montaye, M., Arveiler, D., Evans, A., Bingham, A., Ruidavets, J. B., ... Ferrières, J. (2004). Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 11(4), pp. 336-43.
    Marques-Vidal P, et al. Alcohol Consumption and Cardiovascular Disease: Differential Effects in France and Northern Ireland. the PRIME Study. Eur J Cardiovasc Prev Rehabil. 2004;11(4):336-43. PubMed PMID: 15292768.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study. AU - Marques-Vidal,Pedro, AU - Montaye,Michèle, AU - Arveiler,Dominique, AU - Evans,Alun, AU - Bingham,Annie, AU - Ruidavets,Jean-Bernard, AU - Amouyel,Philippe, AU - Haas,Bernadette, AU - Yarnell,John, AU - Ducimetière,Pierre, AU - Ferrières,Jean, PY - 2004/8/5/pubmed PY - 2006/5/25/medline PY - 2004/8/5/entrez SP - 336 EP - 43 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 11 IS - 4 N2 - BACKGROUND: The effects of wine and other alcoholic beverages on coronary heart disease (CHD) have seldom been studied in several countries using a common methodology. DESIGN: Five-year prospective study conducted among 9750 men (7352 in France and 2398 in Northern Ireland) free of CHD at entry. Outcomes were angina pectoris, myocardial infarction or CHD death. RESULTS: In all, 90% of subjects in France reported drinking at least once per week, versus 61% in Northern Ireland. In France, after adjusting for other CHD risk factors, subjects in the highest quartile of alcohol consumption had a significantly lower risk of developing angina pectoris relative to non-drinkers. For myocardial infarction and all CHD events, the risk also decreased from the first to the fourth quartile (P for trend=0.02). Conversely, in Northern Ireland, no significant relationship was found between alcohol consumption and the incidence of angina pectoris or all CHD events, although alcohol consumption appeared to decrease the risk for myocardial infarction. Similar findings were obtained when the 5% higher alcohol consumers were excluded from the analysis. Finally, splitting the alcohol consumption into wine, beer and spirits did not improve the relationships, the three types of beverage exerting comparable effects on CHD events. CONCLUSIONS: Alcohol consumption patterns exert differential effects on CHD risk in middle-aged men from France and Northern Ireland. Further, the amount of alcohol consumption, rather than the type of alcoholic beverage, is related to both angina pectoris and myocardial infarction in France, whereas no relationship was found in Northern Ireland. SN - 1741-8267 UR - https://www.unboundmedicine.com/medline/citation/15292768/Alcohol_consumption_and_cardiovascular_disease:_differential_effects_in_France_and_Northern_Ireland__The_PRIME_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15292768.ui DB - PRIME DP - Unbound Medicine ER -