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Mitochondria and dopamine: new insights into recessive parkinsonism.
Neuron. 2004 Aug 05; 43(3):301-4.N

Abstract

Recessively inherited mutations in parkin, DJ-1, and PINK1 have recently been linked to familial forms of parkinsonism. These syndromes are often clinically indistinguishable from Parkinson's disease, as similar neuronal groups, notably dopaminergic neurons, are selectively affected. Studies of the functions of these gene products may provide insights into the pathogenic mechanisms underlying the selective degeneration of dopaminergic neurons. Emerging evidence that one or several of these genes play important roles in mitochondrial function and the dopaminergic system suggests that these events may be early steps of the pathophysiological changes of the disease. This review will summarize recent advances in our understanding of these gene products, with emphasis on the surprising convergence of their functions.

Authors+Show Affiliations

Center for Neurologic Diseases, Brigham and Women's Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. jshen@rics.bwh.harvard.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15294138

Citation

Shen, Jie, and Mark R. Cookson. "Mitochondria and Dopamine: New Insights Into Recessive Parkinsonism." Neuron, vol. 43, no. 3, 2004, pp. 301-4.
Shen J, Cookson MR. Mitochondria and dopamine: new insights into recessive parkinsonism. Neuron. 2004;43(3):301-4.
Shen, J., & Cookson, M. R. (2004). Mitochondria and dopamine: new insights into recessive parkinsonism. Neuron, 43(3), 301-4.
Shen J, Cookson MR. Mitochondria and Dopamine: New Insights Into Recessive Parkinsonism. Neuron. 2004 Aug 5;43(3):301-4. PubMed PMID: 15294138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondria and dopamine: new insights into recessive parkinsonism. AU - Shen,Jie, AU - Cookson,Mark R, PY - 2004/8/6/pubmed PY - 2004/11/4/medline PY - 2004/8/6/entrez SP - 301 EP - 4 JF - Neuron JO - Neuron VL - 43 IS - 3 N2 - Recessively inherited mutations in parkin, DJ-1, and PINK1 have recently been linked to familial forms of parkinsonism. These syndromes are often clinically indistinguishable from Parkinson's disease, as similar neuronal groups, notably dopaminergic neurons, are selectively affected. Studies of the functions of these gene products may provide insights into the pathogenic mechanisms underlying the selective degeneration of dopaminergic neurons. Emerging evidence that one or several of these genes play important roles in mitochondrial function and the dopaminergic system suggests that these events may be early steps of the pathophysiological changes of the disease. This review will summarize recent advances in our understanding of these gene products, with emphasis on the surprising convergence of their functions. SN - 0896-6273 UR - https://www.unboundmedicine.com/medline/citation/15294138/Mitochondria_and_dopamine:_new_insights_into_recessive_parkinsonism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896627304004593 DB - PRIME DP - Unbound Medicine ER -
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