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Induction of renal oxidative stress and cell proliferation response by ferric nitrilotriacetate (Fe-NTA): diminution by soy isoflavones.
Chem Biol Interact. 2004 Aug 10; 149(1):23-35.CB

Abstract

Ferric nitrilotriacetate (Fe-NTA) is a known potent nephrotoxic agent. In this communication, we report the chemopreventive effect of soy isoflavones on renal oxidative stress, toxicity and cell proliferation response in Wistar rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances gamma-glutamyl transpeptidase, renal lipid peroxidation, xanthine oxidase and hydrogen peroxide (H2O2) generation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, glutathione reductase, catalase, glucose-6-phosphate dehydrogenase and phase-II metabolising enzymes such as glutathione-S-transferase and quinone reductase. Fe-NTA treatment also induced tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and thymidine [3H] incorporation into renal DNA. A sharp elevation in the levels of blood urea nitrogen and serum creatinine has also been observed. Treatment of rats orally with soy isoflavones (5 mg/kg body weight and 10 mg/kg body weight) resulted in significant decreases in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H2O2 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Renal glutathione content (P < 0.01), glutathione metabolizing enzymes (P < 0.001) and antioxidant enzymes were also returned to normal levels (P < 0.001). Thus, our data suggest that soy isoflavones may be used as an effective chemopreventive agent against Fe-NTA-mediated renal oxidative stress, toxicity and cell proliferation response in Wistar rats.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15294441

Citation

Khan, Naghma, and Sarwat Sultana. "Induction of Renal Oxidative Stress and Cell Proliferation Response By Ferric Nitrilotriacetate (Fe-NTA): Diminution By Soy Isoflavones." Chemico-biological Interactions, vol. 149, no. 1, 2004, pp. 23-35.
Khan N, Sultana S. Induction of renal oxidative stress and cell proliferation response by ferric nitrilotriacetate (Fe-NTA): diminution by soy isoflavones. Chem Biol Interact. 2004;149(1):23-35.
Khan, N., & Sultana, S. (2004). Induction of renal oxidative stress and cell proliferation response by ferric nitrilotriacetate (Fe-NTA): diminution by soy isoflavones. Chemico-biological Interactions, 149(1), 23-35.
Khan N, Sultana S. Induction of Renal Oxidative Stress and Cell Proliferation Response By Ferric Nitrilotriacetate (Fe-NTA): Diminution By Soy Isoflavones. Chem Biol Interact. 2004 Aug 10;149(1):23-35. PubMed PMID: 15294441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of renal oxidative stress and cell proliferation response by ferric nitrilotriacetate (Fe-NTA): diminution by soy isoflavones. AU - Khan,Naghma, AU - Sultana,Sarwat, PY - 2004/05/15/received PY - 2004/06/16/revised PY - 2004/06/16/accepted PY - 2004/8/6/pubmed PY - 2004/9/30/medline PY - 2004/8/6/entrez SP - 23 EP - 35 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 149 IS - 1 N2 - Ferric nitrilotriacetate (Fe-NTA) is a known potent nephrotoxic agent. In this communication, we report the chemopreventive effect of soy isoflavones on renal oxidative stress, toxicity and cell proliferation response in Wistar rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances gamma-glutamyl transpeptidase, renal lipid peroxidation, xanthine oxidase and hydrogen peroxide (H2O2) generation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, glutathione reductase, catalase, glucose-6-phosphate dehydrogenase and phase-II metabolising enzymes such as glutathione-S-transferase and quinone reductase. Fe-NTA treatment also induced tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and thymidine [3H] incorporation into renal DNA. A sharp elevation in the levels of blood urea nitrogen and serum creatinine has also been observed. Treatment of rats orally with soy isoflavones (5 mg/kg body weight and 10 mg/kg body weight) resulted in significant decreases in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H2O2 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Renal glutathione content (P < 0.01), glutathione metabolizing enzymes (P < 0.001) and antioxidant enzymes were also returned to normal levels (P < 0.001). Thus, our data suggest that soy isoflavones may be used as an effective chemopreventive agent against Fe-NTA-mediated renal oxidative stress, toxicity and cell proliferation response in Wistar rats. SN - 0009-2797 UR - https://www.unboundmedicine.com/medline/citation/15294441/Induction_of_renal_oxidative_stress_and_cell_proliferation_response_by_ferric_nitrilotriacetate__Fe_NTA_:_diminution_by_soy_isoflavones_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009279704000651 DB - PRIME DP - Unbound Medicine ER -