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Effect of scoparia dulcis (Sweet Broomweed) plant extract on plasma antioxidants in streptozotocin-induced experimental diabetes in male albino Wistar rats.
Pharmazie. 2004 Jul; 59(7):557-60.P

Abstract

Clinical research has confirmed the efficacy of several plants in the modulation of oxidative stress associated with diabetes mellitus. Scoparia dulcis plant extract is tried for prevention and treatment of diabetes mellitus induced experimentally by streptozotocin injection. A single dose of streptozotocin (45 mg/kg body weight) produced decrease in insulin, hyperglycemia, increased lipid peroxidation (Thiobarbituric reactive substances and lipid hydroperoxides) and decreased antioxidant levels (vitamin C, vitamin E, reduced glutathione, ceruloplasmin). Oral administration of an aqueous extract of Scoparia dulcis plant (200 mg/kg body weight) for 6 weeks to diabetic rats significantly increased the plasma insulin and plasma antioxidants and significantly decreased lipid peroxidation. The effect of Scoparia dulcis plant extract at 200 mg/kg body weight was better than that of glibenclamide, a reference drug.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India. paribala@sancharnet.inNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15296095

Citation

Pari, L, and M Latha. "Effect of Scoparia Dulcis (Sweet Broomweed) Plant Extract On Plasma Antioxidants in Streptozotocin-induced Experimental Diabetes in Male Albino Wistar Rats." Die Pharmazie, vol. 59, no. 7, 2004, pp. 557-60.
Pari L, Latha M. Effect of scoparia dulcis (Sweet Broomweed) plant extract on plasma antioxidants in streptozotocin-induced experimental diabetes in male albino Wistar rats. Pharmazie. 2004;59(7):557-60.
Pari, L., & Latha, M. (2004). Effect of scoparia dulcis (Sweet Broomweed) plant extract on plasma antioxidants in streptozotocin-induced experimental diabetes in male albino Wistar rats. Die Pharmazie, 59(7), 557-60.
Pari L, Latha M. Effect of Scoparia Dulcis (Sweet Broomweed) Plant Extract On Plasma Antioxidants in Streptozotocin-induced Experimental Diabetes in Male Albino Wistar Rats. Pharmazie. 2004;59(7):557-60. PubMed PMID: 15296095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of scoparia dulcis (Sweet Broomweed) plant extract on plasma antioxidants in streptozotocin-induced experimental diabetes in male albino Wistar rats. AU - Pari,L, AU - Latha,M, PY - 2004/8/7/pubmed PY - 2004/9/4/medline PY - 2004/8/7/entrez SP - 557 EP - 60 JF - Die Pharmazie JO - Pharmazie VL - 59 IS - 7 N2 - Clinical research has confirmed the efficacy of several plants in the modulation of oxidative stress associated with diabetes mellitus. Scoparia dulcis plant extract is tried for prevention and treatment of diabetes mellitus induced experimentally by streptozotocin injection. A single dose of streptozotocin (45 mg/kg body weight) produced decrease in insulin, hyperglycemia, increased lipid peroxidation (Thiobarbituric reactive substances and lipid hydroperoxides) and decreased antioxidant levels (vitamin C, vitamin E, reduced glutathione, ceruloplasmin). Oral administration of an aqueous extract of Scoparia dulcis plant (200 mg/kg body weight) for 6 weeks to diabetic rats significantly increased the plasma insulin and plasma antioxidants and significantly decreased lipid peroxidation. The effect of Scoparia dulcis plant extract at 200 mg/kg body weight was better than that of glibenclamide, a reference drug. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15296095/Effect_of_scoparia_dulcis__Sweet_Broomweed__plant_extract_on_plasma_antioxidants_in_streptozotocin_induced_experimental_diabetes_in_male_albino_Wistar_rats_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -