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Intranasal immunization with outer membrane protein P6 and cholera toxin induces specific sinus mucosal immunity and enhances sinus clearance of nontypeable Haemophilus influenzae.
Vaccine. 2004 Aug 13; 22(23-24):3112-21.V

Abstract

Nontypeable Haemophilus influenzae (NTHi) is one of the leading pathogens in sinusitis. One of the outer membrane proteins of NTHi, P6, is a common antigen to all strains and is an attractive candidate for a subunit bacterial vaccine. In this study, we characterized normal sinus mucosa (SM) and investigated the potential of intranasal immunization with P6 and cholera toxin (CT) for induction of mucosal protective immunity against NTHi in the maxillary sinuses of rats. Intranasal immunization induced P6-specific sinus mucosal and systemic immunological responses, mainly of the IgA and IgG isotype. The protective effect of intranasal immunization was demonstrated by enhancement of sinus clearance of NTHi. The present study showed that unilateral intranasal immunization has a capacity to induce protective immunity against NTHi in the bilateral maxillary sinuses. Systemic administration of the vaccine did not affect sinus clearance of NTHi. These findings suggest that a nasal vaccine might be useful for preventing sinusitis.

Authors+Show Affiliations

Department of Otolaryngology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15297063

Citation

Sabirov, Albert, et al. "Intranasal Immunization With Outer Membrane Protein P6 and Cholera Toxin Induces Specific Sinus Mucosal Immunity and Enhances Sinus Clearance of Nontypeable Haemophilus Influenzae." Vaccine, vol. 22, no. 23-24, 2004, pp. 3112-21.
Sabirov A, Kodama S, Sabirova N, et al. Intranasal immunization with outer membrane protein P6 and cholera toxin induces specific sinus mucosal immunity and enhances sinus clearance of nontypeable Haemophilus influenzae. Vaccine. 2004;22(23-24):3112-21.
Sabirov, A., Kodama, S., Sabirova, N., Mogi, G., & Suzuki, M. (2004). Intranasal immunization with outer membrane protein P6 and cholera toxin induces specific sinus mucosal immunity and enhances sinus clearance of nontypeable Haemophilus influenzae. Vaccine, 22(23-24), 3112-21.
Sabirov A, et al. Intranasal Immunization With Outer Membrane Protein P6 and Cholera Toxin Induces Specific Sinus Mucosal Immunity and Enhances Sinus Clearance of Nontypeable Haemophilus Influenzae. Vaccine. 2004 Aug 13;22(23-24):3112-21. PubMed PMID: 15297063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intranasal immunization with outer membrane protein P6 and cholera toxin induces specific sinus mucosal immunity and enhances sinus clearance of nontypeable Haemophilus influenzae. AU - Sabirov,Albert, AU - Kodama,Satoru, AU - Sabirova,Nailya, AU - Mogi,Goro, AU - Suzuki,Masashi, PY - 2003/10/06/received PY - 2004/01/27/revised PY - 2004/01/28/accepted PY - 2004/8/7/pubmed PY - 2004/11/13/medline PY - 2004/8/7/entrez SP - 3112 EP - 21 JF - Vaccine JO - Vaccine VL - 22 IS - 23-24 N2 - Nontypeable Haemophilus influenzae (NTHi) is one of the leading pathogens in sinusitis. One of the outer membrane proteins of NTHi, P6, is a common antigen to all strains and is an attractive candidate for a subunit bacterial vaccine. In this study, we characterized normal sinus mucosa (SM) and investigated the potential of intranasal immunization with P6 and cholera toxin (CT) for induction of mucosal protective immunity against NTHi in the maxillary sinuses of rats. Intranasal immunization induced P6-specific sinus mucosal and systemic immunological responses, mainly of the IgA and IgG isotype. The protective effect of intranasal immunization was demonstrated by enhancement of sinus clearance of NTHi. The present study showed that unilateral intranasal immunization has a capacity to induce protective immunity against NTHi in the bilateral maxillary sinuses. Systemic administration of the vaccine did not affect sinus clearance of NTHi. These findings suggest that a nasal vaccine might be useful for preventing sinusitis. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/15297063/Intranasal_immunization_with_outer_membrane_protein_P6_and_cholera_toxin_induces_specific_sinus_mucosal_immunity_and_enhances_sinus_clearance_of_nontypeable_Haemophilus_influenzae_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264410X04001781 DB - PRIME DP - Unbound Medicine ER -