Tags

Type your tag names separated by a space and hit enter

Basal and postprandial substrate oxidation rates in obese women receiving two test meals with different protein content.
Clin Nutr. 2004 Aug; 23(4):571-8.CN

Abstract

BACKGROUND & AIMS

Fuel utilisation and storage in lean and obese subjects seem to be differently affected by the macronutrient distribution intake. The aim of this intervention study was to explore the extent to which the fat mass status and the macronutrient composition of an acute dietary intake influence substrate oxidation rates.

METHODS

Fuel utilisation in 26 women, 14 obese (BMI = 37.1 +/- 1.1 kg/m2) and 12 lean (BMI = 20.6 +/- 0.5 kg/m2) was measured over 6 h to compare the metabolic effect of a single balanced protein (HC) meal and a high protein (HP) single meal, which were designed to supply similar energy contents (1672 kJ). The macronutrient composition as a percentage of energy of the HC meal was 55% carbohydrate, 15% protein and 30% fat, while the HP meal contained 40% carbohydrate, 30% protein and 30% fat. Nutrient oxidation rates and energy expenditure were calculated by indirect calorimetry (hood system), whereas exogenous amino acid oxidation was estimated from the 13C isotopic enrichment of breath after oral administration of L[1-13C]leucine.

RESULTS

Fasting lipid oxidation was higher in the obese than in the lean women (P < 0.05), and it was significantly correlated with body fatness (P < 0.01). A single HP meal consumption produced higher postprandial fat oxidation as compared with HC meal intake (P < 0.02), in both obese and lean subjects, with no apparent changes in glucose oxidation rates. Furthermore, postprandial fat utilisation after the test meal intake was higher in obese than in the lean women (P < 0.01). The time course of 13CO2 in breath followed a similar pattern in both dietary groups, although a non-statistically significant higher trend in protein and 13C-leucine oxidation was found in the HP group.

CONCLUSIONS

Net lipid oxidation depends on both short-term dietary composition intake and fat body mass, being significantly higher after a relatively high protein meal as compared to a balanced diet intake and in obese women as compared to lean controls.

Authors+Show Affiliations

Department of Physiology and Nutrition, University of Navarra, Irunlarrea, 1, 31008 Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15297093

Citation

Labayen, I, et al. "Basal and Postprandial Substrate Oxidation Rates in Obese Women Receiving Two Test Meals With Different Protein Content." Clinical Nutrition (Edinburgh, Scotland), vol. 23, no. 4, 2004, pp. 571-8.
Labayen I, Díez N, Parra D, et al. Basal and postprandial substrate oxidation rates in obese women receiving two test meals with different protein content. Clin Nutr. 2004;23(4):571-8.
Labayen, I., Díez, N., Parra, D., González, A., & Martínez, J. A. (2004). Basal and postprandial substrate oxidation rates in obese women receiving two test meals with different protein content. Clinical Nutrition (Edinburgh, Scotland), 23(4), 571-8.
Labayen I, et al. Basal and Postprandial Substrate Oxidation Rates in Obese Women Receiving Two Test Meals With Different Protein Content. Clin Nutr. 2004;23(4):571-8. PubMed PMID: 15297093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basal and postprandial substrate oxidation rates in obese women receiving two test meals with different protein content. AU - Labayen,I, AU - Díez,N, AU - Parra,D, AU - González,A, AU - Martínez,J A, PY - 2002/12/19/received PY - 2003/10/09/accepted PY - 2004/8/7/pubmed PY - 2005/4/13/medline PY - 2004/8/7/entrez SP - 571 EP - 8 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 23 IS - 4 N2 - BACKGROUND & AIMS: Fuel utilisation and storage in lean and obese subjects seem to be differently affected by the macronutrient distribution intake. The aim of this intervention study was to explore the extent to which the fat mass status and the macronutrient composition of an acute dietary intake influence substrate oxidation rates. METHODS: Fuel utilisation in 26 women, 14 obese (BMI = 37.1 +/- 1.1 kg/m2) and 12 lean (BMI = 20.6 +/- 0.5 kg/m2) was measured over 6 h to compare the metabolic effect of a single balanced protein (HC) meal and a high protein (HP) single meal, which were designed to supply similar energy contents (1672 kJ). The macronutrient composition as a percentage of energy of the HC meal was 55% carbohydrate, 15% protein and 30% fat, while the HP meal contained 40% carbohydrate, 30% protein and 30% fat. Nutrient oxidation rates and energy expenditure were calculated by indirect calorimetry (hood system), whereas exogenous amino acid oxidation was estimated from the 13C isotopic enrichment of breath after oral administration of L[1-13C]leucine. RESULTS: Fasting lipid oxidation was higher in the obese than in the lean women (P < 0.05), and it was significantly correlated with body fatness (P < 0.01). A single HP meal consumption produced higher postprandial fat oxidation as compared with HC meal intake (P < 0.02), in both obese and lean subjects, with no apparent changes in glucose oxidation rates. Furthermore, postprandial fat utilisation after the test meal intake was higher in obese than in the lean women (P < 0.01). The time course of 13CO2 in breath followed a similar pattern in both dietary groups, although a non-statistically significant higher trend in protein and 13C-leucine oxidation was found in the HP group. CONCLUSIONS: Net lipid oxidation depends on both short-term dietary composition intake and fat body mass, being significantly higher after a relatively high protein meal as compared to a balanced diet intake and in obese women as compared to lean controls. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/15297093/Basal_and_postprandial_substrate_oxidation_rates_in_obese_women_receiving_two_test_meals_with_different_protein_content_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261561403002152 DB - PRIME DP - Unbound Medicine ER -