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Effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study -- 24 months results of the Study of Prevention of Allergy in Children in Europe.
Clin Exp Allergy 2004; 34(8):1220-5CE

Abstract

BACKGROUND

Sensitization to house dust mite (HDM) is an important risk factor for the development of asthma and allergic disease in childhood. Higher levels of HDM allergen are linked to increased sensitization to HDM.

OBJECTIVE

To study the effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a newborn cohort.

METHODS

Six hundred and ninety-six newborns at high risk of developing allergies were enrolled in three European countries (Germany, Austria, UK) in a prospective, randomized, controlled birth-cohort study. Children were randomly assigned to an intervention and control group. Intervention measures included the use of mite-impermeable mattress encasings for the child's bed and a simple educational package on allergen avoidance. The control group received basic information about allergies. Children were followed up at age 6, 12, 18 and 24 months.

RESULTS

80.9% of the children were followed up to the age of 24 months. No difference in the prevalence of sensitization to HDM (control vs. intervention group: 8.4% vs. 6.1%, P=0.33) or the development of symptoms (recurrent wheezing 10.3% vs. 10.7%, nocturnal cough 12.5% vs. 12.5%) or allergic diseases (asthma 3.5% vs. 5.1%, eczema 20.0% vs. 19.6%, rhinitis 28.9% vs. 25.8%) could be found between the control and intervention group.

CONCLUSION

In this study, HDM avoidance did not show a protective effect on the development of sensitization to HDM or symptomatic allergy in children at age 24 months.

Authors+Show Affiliations

University Children's Hospital, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15298561

Citation

Horak, F, et al. "Effect of Mite-impermeable Mattress Encasings and an Educational Package On the Development of Allergies in a Multinational Randomized, Controlled Birth-cohort Study -- 24 Months Results of the Study of Prevention of Allergy in Children in Europe." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 34, no. 8, 2004, pp. 1220-5.
Horak F, Matthews S, Ihorst G, et al. Effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study -- 24 months results of the Study of Prevention of Allergy in Children in Europe. Clin Exp Allergy. 2004;34(8):1220-5.
Horak, F., Matthews, S., Ihorst, G., Arshad, S. H., Frischer, T., Kuehr, J., ... Forster, J. (2004). Effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study -- 24 months results of the Study of Prevention of Allergy in Children in Europe. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 34(8), pp. 1220-5.
Horak F, et al. Effect of Mite-impermeable Mattress Encasings and an Educational Package On the Development of Allergies in a Multinational Randomized, Controlled Birth-cohort Study -- 24 Months Results of the Study of Prevention of Allergy in Children in Europe. Clin Exp Allergy. 2004;34(8):1220-5. PubMed PMID: 15298561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study -- 24 months results of the Study of Prevention of Allergy in Children in Europe. AU - Horak,F,Jr AU - Matthews,S, AU - Ihorst,G, AU - Arshad,S H, AU - Frischer,T, AU - Kuehr,J, AU - Schwieger,A, AU - Forster,J, AU - ,, PY - 2004/8/10/pubmed PY - 2004/12/21/medline PY - 2004/8/10/entrez SP - 1220 EP - 5 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 34 IS - 8 N2 - BACKGROUND: Sensitization to house dust mite (HDM) is an important risk factor for the development of asthma and allergic disease in childhood. Higher levels of HDM allergen are linked to increased sensitization to HDM. OBJECTIVE: To study the effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a newborn cohort. METHODS: Six hundred and ninety-six newborns at high risk of developing allergies were enrolled in three European countries (Germany, Austria, UK) in a prospective, randomized, controlled birth-cohort study. Children were randomly assigned to an intervention and control group. Intervention measures included the use of mite-impermeable mattress encasings for the child's bed and a simple educational package on allergen avoidance. The control group received basic information about allergies. Children were followed up at age 6, 12, 18 and 24 months. RESULTS: 80.9% of the children were followed up to the age of 24 months. No difference in the prevalence of sensitization to HDM (control vs. intervention group: 8.4% vs. 6.1%, P=0.33) or the development of symptoms (recurrent wheezing 10.3% vs. 10.7%, nocturnal cough 12.5% vs. 12.5%) or allergic diseases (asthma 3.5% vs. 5.1%, eczema 20.0% vs. 19.6%, rhinitis 28.9% vs. 25.8%) could be found between the control and intervention group. CONCLUSION: In this study, HDM avoidance did not show a protective effect on the development of sensitization to HDM or symptomatic allergy in children at age 24 months. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/15298561/Effect_of_mite_impermeable_mattress_encasings_and_an_educational_package_on_the_development_of_allergies_in_a_multinational_randomized_controlled_birth_cohort_study____24_months_results_of_the_Study_of_Prevention_of_Allergy_in_Children_in_Europe_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2004&volume=34&issue=8&spage=1220 DB - PRIME DP - Unbound Medicine ER -