Tags

Type your tag names separated by a space and hit enter

Specific immunoglobulin E for staphylococcal enterotoxins in nasal polyps from patients with aspirin-intolerant asthma.
Clin Exp Allergy. 2004 Aug; 34(8):1270-5.CE

Abstract

BACKGROUND

Nasal polyps infiltrated with eosinophils are commonly found in chronic asthmatic patients, more frequently in those with aspirin-intolerant asthma (AIA) than aspirin-tolerant asthma (ATA). Some studies have suggested a contribution of superantigens derived from Staphylococcus sp to nasal polyposis and eosinophilia, but their relative importance in AIA and ATA subjects is unknown.

OBJECTIVE

We investigated whether local production of specific IgE to staphylococcal enterotoxins A and B (SEA and SEB) and relationships with markers of eosinophilic inflammation differ in the nasal polyps of AIA and ATA subjects.

METHODS

Fifteen AIA subjects with positive responses to lysine-aspirin bronchoprovocation and 15 ATA subjects underwent polypectomy. Immunoassays were used to quantify eosinophil cationic protein (ECP), IL-5, mast cell tryptase, soluble IL-2 receptors (sIL-2R), total IgE, and specific IgE for SEA and SEB.

RESULTS

ECP levels in nasal polyp homogenates were higher in AIA subjects than in ATA subjects (P < 0.02), with no significant differences in tryptase, IL-5 or sIL-2R. Total IgE, and specific IgE to both SEA and SEB, were detectable in some nasal polyps from both subject groups, but median levels were markedly higher in AIA subjects than in ATA subjects (P = 0.04, 0.01, 0.05, respectively). Levels of specific IgE to SEA and SEB correlated significantly with levels of ECP and IL-5, but not those of tryptase or sIL-2R.

CONCLUSION

These findings suggest that staphylococcal superantigens may drive local eosinophilic inflammation in nasal polyp tissue, and that this is exacerbated in subjects with AIA.

Authors+Show Affiliations

Department of Allergy & Rheumatology, Ajou University School of Medicine, Suwon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15298569

Citation

Suh, Y J., et al. "Specific Immunoglobulin E for Staphylococcal Enterotoxins in Nasal Polyps From Patients With Aspirin-intolerant Asthma." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 34, no. 8, 2004, pp. 1270-5.
Suh YJ, Yoon SH, Sampson AP, et al. Specific immunoglobulin E for staphylococcal enterotoxins in nasal polyps from patients with aspirin-intolerant asthma. Clin Exp Allergy. 2004;34(8):1270-5.
Suh, Y. J., Yoon, S. H., Sampson, A. P., Kim, H. J., Kim, S. H., Nahm, D. H., Suh, C. H., & Park, H. S. (2004). Specific immunoglobulin E for staphylococcal enterotoxins in nasal polyps from patients with aspirin-intolerant asthma. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 34(8), 1270-5.
Suh YJ, et al. Specific Immunoglobulin E for Staphylococcal Enterotoxins in Nasal Polyps From Patients With Aspirin-intolerant Asthma. Clin Exp Allergy. 2004;34(8):1270-5. PubMed PMID: 15298569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific immunoglobulin E for staphylococcal enterotoxins in nasal polyps from patients with aspirin-intolerant asthma. AU - Suh,Y J, AU - Yoon,S H, AU - Sampson,A P, AU - Kim,H J, AU - Kim,S H, AU - Nahm,D H, AU - Suh,C H, AU - Park,H S, PY - 2004/8/10/pubmed PY - 2004/12/21/medline PY - 2004/8/10/entrez SP - 1270 EP - 5 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 34 IS - 8 N2 - BACKGROUND: Nasal polyps infiltrated with eosinophils are commonly found in chronic asthmatic patients, more frequently in those with aspirin-intolerant asthma (AIA) than aspirin-tolerant asthma (ATA). Some studies have suggested a contribution of superantigens derived from Staphylococcus sp to nasal polyposis and eosinophilia, but their relative importance in AIA and ATA subjects is unknown. OBJECTIVE: We investigated whether local production of specific IgE to staphylococcal enterotoxins A and B (SEA and SEB) and relationships with markers of eosinophilic inflammation differ in the nasal polyps of AIA and ATA subjects. METHODS: Fifteen AIA subjects with positive responses to lysine-aspirin bronchoprovocation and 15 ATA subjects underwent polypectomy. Immunoassays were used to quantify eosinophil cationic protein (ECP), IL-5, mast cell tryptase, soluble IL-2 receptors (sIL-2R), total IgE, and specific IgE for SEA and SEB. RESULTS: ECP levels in nasal polyp homogenates were higher in AIA subjects than in ATA subjects (P < 0.02), with no significant differences in tryptase, IL-5 or sIL-2R. Total IgE, and specific IgE to both SEA and SEB, were detectable in some nasal polyps from both subject groups, but median levels were markedly higher in AIA subjects than in ATA subjects (P = 0.04, 0.01, 0.05, respectively). Levels of specific IgE to SEA and SEB correlated significantly with levels of ECP and IL-5, but not those of tryptase or sIL-2R. CONCLUSION: These findings suggest that staphylococcal superantigens may drive local eosinophilic inflammation in nasal polyp tissue, and that this is exacerbated in subjects with AIA. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/15298569/Specific_immunoglobulin_E_for_staphylococcal_enterotoxins_in_nasal_polyps_from_patients_with_aspirin_intolerant_asthma_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0954-7894&amp;date=2004&amp;volume=34&amp;issue=8&amp;spage=1270 DB - PRIME DP - Unbound Medicine ER -