Tags

Type your tag names separated by a space and hit enter

Oxidants, antioxidants and the ischemic brain.
J Exp Biol. 2004 Aug; 207(Pt 18):3221-31.JE

Abstract

Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads to formation of highly reactive products, including peroxynitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Use of transgenic mutants and selective pharmacological antioxidants has greatly increased understanding of the complex interplay between substrate deprivation and ischemic outcome. Recent evidence that reactive oxygen/nitrogen species play a critical role in initiation of apoptosis, mitochondrial permeability transition and poly(ADP-ribose) polymerase activation provides additional mechanisms for oxidative damage and new targets for post-ischemic therapeutic intervention. Because oxidative stress involves multiple post-ischemic cascades leading to cell death, effective prevention/treatment of ischemic brain injury is likely to require intervention at multiple effect sites.

Authors+Show Affiliations

Department of Anesthesiology, The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA. warne002@mc.duke.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15299043

Citation

Warner, David S., et al. "Oxidants, Antioxidants and the Ischemic Brain." The Journal of Experimental Biology, vol. 207, no. Pt 18, 2004, pp. 3221-31.
Warner DS, Sheng H, Batinić-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol. 2004;207(Pt 18):3221-31.
Warner, D. S., Sheng, H., & Batinić-Haberle, I. (2004). Oxidants, antioxidants and the ischemic brain. The Journal of Experimental Biology, 207(Pt 18), 3221-31.
Warner DS, Sheng H, Batinić-Haberle I. Oxidants, Antioxidants and the Ischemic Brain. J Exp Biol. 2004;207(Pt 18):3221-31. PubMed PMID: 15299043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidants, antioxidants and the ischemic brain. AU - Warner,David S, AU - Sheng,Huaxin, AU - Batinić-Haberle,Ines, PY - 2004/8/10/pubmed PY - 2004/12/22/medline PY - 2004/8/10/entrez SP - 3221 EP - 31 JF - The Journal of experimental biology JO - J Exp Biol VL - 207 IS - Pt 18 N2 - Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads to formation of highly reactive products, including peroxynitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Use of transgenic mutants and selective pharmacological antioxidants has greatly increased understanding of the complex interplay between substrate deprivation and ischemic outcome. Recent evidence that reactive oxygen/nitrogen species play a critical role in initiation of apoptosis, mitochondrial permeability transition and poly(ADP-ribose) polymerase activation provides additional mechanisms for oxidative damage and new targets for post-ischemic therapeutic intervention. Because oxidative stress involves multiple post-ischemic cascades leading to cell death, effective prevention/treatment of ischemic brain injury is likely to require intervention at multiple effect sites. SN - 0022-0949 UR - https://www.unboundmedicine.com/medline/citation/15299043/Oxidants_antioxidants_and_the_ischemic_brain_ L2 - http://jeb.biologists.org/cgi/pmidlookup?view=long&pmid=15299043 DB - PRIME DP - Unbound Medicine ER -