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Value of routine duodenal biopsy in diagnosing coeliac disease in patients with iron deficiency anaemia.
Postgrad Med J. 2004 Aug; 80(946):475-7.PM

Abstract

BACKGROUND

Iron deficiency anaemia (IDA) is a recognised feature of coeliac disease in adults and can be its only presentation.

OBJECTIVE

To determine the yield of routine distal duodenal biopsies in diagnosing coeliac disease in adult and elderly patients with IDA whose endoscopy revealed no upper gastrointestinal cause of iron deficiency.

STUDY DESIGN

Prospective study in a teaching hospital endoscopy unit.

METHOD

Altogether 504 consecutive patients with IDA, aged 16-80 years, attending for endoscopy were included in this study. At least two distal duodenal biopsies were taken if endoscopy revealed no cause of iron deficiency.

RESULT

In nine (1.8%) patients duodenal biopsies revealed typical histological features of coeliac disease. Of these, five patients were above 65 years old.

CONCLUSION

In adult and elderly patients undergoing endoscopy for IDA, the endoscopist should take distal duodenal biopsies to exclude coeliac disease if no upper gastrointestinal cause of anaemia is found. Coeliac disease is not an uncommon cause of IDA in patients >65 years of age and a history of chronic diarrhoea increases diagnostic yield in this age group.

Authors+Show Affiliations

Department of Integrated Medicine, Leicester General Hospital, UK. adityamandal@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15299158

Citation

Mandal, A K., et al. "Value of Routine Duodenal Biopsy in Diagnosing Coeliac Disease in Patients With Iron Deficiency Anaemia." Postgraduate Medical Journal, vol. 80, no. 946, 2004, pp. 475-7.
Mandal AK, Mehdi I, Munshi SK, et al. Value of routine duodenal biopsy in diagnosing coeliac disease in patients with iron deficiency anaemia. Postgrad Med J. 2004;80(946):475-7.
Mandal, A. K., Mehdi, I., Munshi, S. K., & Lo, T. C. (2004). Value of routine duodenal biopsy in diagnosing coeliac disease in patients with iron deficiency anaemia. Postgraduate Medical Journal, 80(946), 475-7.
Mandal AK, et al. Value of Routine Duodenal Biopsy in Diagnosing Coeliac Disease in Patients With Iron Deficiency Anaemia. Postgrad Med J. 2004;80(946):475-7. PubMed PMID: 15299158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of routine duodenal biopsy in diagnosing coeliac disease in patients with iron deficiency anaemia. AU - Mandal,A K, AU - Mehdi,I, AU - Munshi,S K, AU - Lo,T C N, PY - 2004/8/10/pubmed PY - 2004/10/16/medline PY - 2004/8/10/entrez SP - 475 EP - 7 JF - Postgraduate medical journal JO - Postgrad Med J VL - 80 IS - 946 N2 - BACKGROUND: Iron deficiency anaemia (IDA) is a recognised feature of coeliac disease in adults and can be its only presentation. OBJECTIVE: To determine the yield of routine distal duodenal biopsies in diagnosing coeliac disease in adult and elderly patients with IDA whose endoscopy revealed no upper gastrointestinal cause of iron deficiency. STUDY DESIGN: Prospective study in a teaching hospital endoscopy unit. METHOD: Altogether 504 consecutive patients with IDA, aged 16-80 years, attending for endoscopy were included in this study. At least two distal duodenal biopsies were taken if endoscopy revealed no cause of iron deficiency. RESULT: In nine (1.8%) patients duodenal biopsies revealed typical histological features of coeliac disease. Of these, five patients were above 65 years old. CONCLUSION: In adult and elderly patients undergoing endoscopy for IDA, the endoscopist should take distal duodenal biopsies to exclude coeliac disease if no upper gastrointestinal cause of anaemia is found. Coeliac disease is not an uncommon cause of IDA in patients >65 years of age and a history of chronic diarrhoea increases diagnostic yield in this age group. SN - 0032-5473 UR - https://www.unboundmedicine.com/medline/citation/15299158/Value_of_routine_duodenal_biopsy_in_diagnosing_coeliac_disease_in_patients_with_iron_deficiency_anaemia_ L2 - http://pmj.bmj.com/cgi/pmidlookup?view=long&pmid=15299158 DB - PRIME DP - Unbound Medicine ER -