Tags

Type your tag names separated by a space and hit enter

Measurement of insulin-like growth factor axis does not enhance specificity of PSA-based prostate cancer screening.
Urology. 2004 Aug; 64(2):317-22.U

Abstract

OBJECTIVES

To examine whether measurement of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein (IGFBP)-2 or IGFBP-3, alone or in combination, enhanced the specificity of prostate cancer detection among men with a prostate-specific antigen (PSA) level of 3 ng/mL or greater beyond that achieved by the free/total PSA index.

METHODS

Cross-sectional analysis was performed on blood samples taken from 597 asymptomatic men (79% of those biopsied) participating in a community case-finding exercise. All men had a total PSA level of 3 ng/mL or greater and had undergone prostate biopsy. Assays of IGF-I, IGF-II, IGFBP-2, IGFBP-3, and free and total PSA were performed. The predictive performance of a range of measures was assessed using receiver operating characteristic analyses and compared with the free/total PSA index, for all biopsies and for men with a PSA level of 3 to 10 ng/mL. The overall test performance was summarized using the area under the receiver operating characteristic curve (AUC).

RESULTS

Of the 597 men, 185 (31.0%) had prostate cancer identified at biopsy. When all biopsies were included, the performance of the free/total PSA index (AUC 0.73) was significantly greater than for IGF-I (AUC 0.59; P <0.0001), IGF-I/PSA ratio (AUC 0.65; P = 0.002), IGF-I + IGFBP-3 (AUC 0.59; P <0.0001), IGF-II (AUC 0.66; P = 0.002), and IGF-II + IGFBP-3 (AUC 0.67; P = 0.05). The combined measurement of free/total PSA, IGF-II, and IGFBP-3 resulted in a slight improvement in performance (AUC 0.76; P = 0.01). The results were similar when the analyses were restricted to men with an initial PSA level of 3 to 10 ng/mL.

CONCLUSIONS

We found no evidence that measurement of the IGF axis enhances the specificity of prostate cancer detection in clinical practice beyond that achievable using the free/total PSA index.

Authors+Show Affiliations

Department of Health Sciences, University of York and Hull York Medical School, York, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15302487

Citation

Oliver, Steven E., et al. "Measurement of Insulin-like Growth Factor Axis Does Not Enhance Specificity of PSA-based Prostate Cancer Screening." Urology, vol. 64, no. 2, 2004, pp. 317-22.
Oliver SE, Holly J, Peters TJ, et al. Measurement of insulin-like growth factor axis does not enhance specificity of PSA-based prostate cancer screening. Urology. 2004;64(2):317-22.
Oliver, S. E., Holly, J., Peters, T. J., Donovan, J., Persad, R., Gillatt, D., Pearce, A., Hamdy, F. C., Neal, D. E., & Gunnell, D. (2004). Measurement of insulin-like growth factor axis does not enhance specificity of PSA-based prostate cancer screening. Urology, 64(2), 317-22.
Oliver SE, et al. Measurement of Insulin-like Growth Factor Axis Does Not Enhance Specificity of PSA-based Prostate Cancer Screening. Urology. 2004;64(2):317-22. PubMed PMID: 15302487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of insulin-like growth factor axis does not enhance specificity of PSA-based prostate cancer screening. AU - Oliver,Steven E, AU - Holly,Jeff, AU - Peters,Tim J, AU - Donovan,Jenny, AU - Persad,Raj, AU - Gillatt,David, AU - Pearce,Anya, AU - Hamdy,Freddie C, AU - Neal,David E, AU - Gunnell,David, PY - 2003/06/17/received PY - 2004/03/09/accepted PY - 2004/8/11/pubmed PY - 2005/2/24/medline PY - 2004/8/11/entrez SP - 317 EP - 22 JF - Urology JO - Urology VL - 64 IS - 2 N2 - OBJECTIVES: To examine whether measurement of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein (IGFBP)-2 or IGFBP-3, alone or in combination, enhanced the specificity of prostate cancer detection among men with a prostate-specific antigen (PSA) level of 3 ng/mL or greater beyond that achieved by the free/total PSA index. METHODS: Cross-sectional analysis was performed on blood samples taken from 597 asymptomatic men (79% of those biopsied) participating in a community case-finding exercise. All men had a total PSA level of 3 ng/mL or greater and had undergone prostate biopsy. Assays of IGF-I, IGF-II, IGFBP-2, IGFBP-3, and free and total PSA were performed. The predictive performance of a range of measures was assessed using receiver operating characteristic analyses and compared with the free/total PSA index, for all biopsies and for men with a PSA level of 3 to 10 ng/mL. The overall test performance was summarized using the area under the receiver operating characteristic curve (AUC). RESULTS: Of the 597 men, 185 (31.0%) had prostate cancer identified at biopsy. When all biopsies were included, the performance of the free/total PSA index (AUC 0.73) was significantly greater than for IGF-I (AUC 0.59; P <0.0001), IGF-I/PSA ratio (AUC 0.65; P = 0.002), IGF-I + IGFBP-3 (AUC 0.59; P <0.0001), IGF-II (AUC 0.66; P = 0.002), and IGF-II + IGFBP-3 (AUC 0.67; P = 0.05). The combined measurement of free/total PSA, IGF-II, and IGFBP-3 resulted in a slight improvement in performance (AUC 0.76; P = 0.01). The results were similar when the analyses were restricted to men with an initial PSA level of 3 to 10 ng/mL. CONCLUSIONS: We found no evidence that measurement of the IGF axis enhances the specificity of prostate cancer detection in clinical practice beyond that achievable using the free/total PSA index. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/15302487/Measurement_of_insulin_like_growth_factor_axis_does_not_enhance_specificity_of_PSA_based_prostate_cancer_screening_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090429504003358 DB - PRIME DP - Unbound Medicine ER -