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Increasing production of homocysteine and neopterin and degradation of tryptophan with older age.
Clin Biochem 2004; 37(8):684-7CB

Abstract

OBJECTIVES

Aging is associated with an increased frequency of abnormal immune system function, which may cause infections, autoimmune diseases, and cardiovascular or neurodegenerative disorders. Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation. Homocysteine is known to be elevated in the elderly, which is possibly due to an insufficient availability of folate, B6, and/or B12.

DESIGN AND METHODS

Serum concentrations of neopterin, homocysteine, tryptophan and kynurenine, and of vitamins folate and B12 were measured in 43 healthy individuals (21 females, 22 males) aged 34-93 years. The ratio of the concentration of the product of IDO, kynurenine, versus the substrate tryptophan (kyn/trp) was calculated to estimate IDO activity.

RESULTS

Comparing three age groups of similar size (34-60, 61-71, and 72-93 years), neopterin and homocysteine concentrations as well as the kyn/trp ratio were found to increase with older age (all P < 0.01). Folate concentrations were lower in the middle-aged group as compared with the other two subgroups of individuals. Vitamin B12 concentrations did not differ between groups. Positive correlations were found between kyn/trp and neopterin and homocysteine concentrations (all P < 0.01).

CONCLUSIONS

Increasing neopterin concentrations and kyn/trp with older age are in line with the view that aging in healthy people is associated with immune activation especially of the T-cell/macrophage system.

Authors+Show Affiliations

Institute of Medical Chemistry and Biochemistry, Leopold-Franzens University, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15302611

Citation

Frick, Barbara, et al. "Increasing Production of Homocysteine and Neopterin and Degradation of Tryptophan With Older Age." Clinical Biochemistry, vol. 37, no. 8, 2004, pp. 684-7.
Frick B, Schroecksnadel K, Neurauter G, et al. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem. 2004;37(8):684-7.
Frick, B., Schroecksnadel, K., Neurauter, G., Leblhuber, F., & Fuchs, D. (2004). Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clinical Biochemistry, 37(8), pp. 684-7.
Frick B, et al. Increasing Production of Homocysteine and Neopterin and Degradation of Tryptophan With Older Age. Clin Biochem. 2004;37(8):684-7. PubMed PMID: 15302611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. AU - Frick,Barbara, AU - Schroecksnadel,Katharina, AU - Neurauter,Gabriele, AU - Leblhuber,Friedrich, AU - Fuchs,Dietmar, PY - 2003/10/29/received PY - 2004/01/27/revised PY - 2004/02/17/accepted PY - 2004/8/11/pubmed PY - 2005/2/19/medline PY - 2004/8/11/entrez SP - 684 EP - 7 JF - Clinical biochemistry JO - Clin. Biochem. VL - 37 IS - 8 N2 - OBJECTIVES: Aging is associated with an increased frequency of abnormal immune system function, which may cause infections, autoimmune diseases, and cardiovascular or neurodegenerative disorders. Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation. Homocysteine is known to be elevated in the elderly, which is possibly due to an insufficient availability of folate, B6, and/or B12. DESIGN AND METHODS: Serum concentrations of neopterin, homocysteine, tryptophan and kynurenine, and of vitamins folate and B12 were measured in 43 healthy individuals (21 females, 22 males) aged 34-93 years. The ratio of the concentration of the product of IDO, kynurenine, versus the substrate tryptophan (kyn/trp) was calculated to estimate IDO activity. RESULTS: Comparing three age groups of similar size (34-60, 61-71, and 72-93 years), neopterin and homocysteine concentrations as well as the kyn/trp ratio were found to increase with older age (all P < 0.01). Folate concentrations were lower in the middle-aged group as compared with the other two subgroups of individuals. Vitamin B12 concentrations did not differ between groups. Positive correlations were found between kyn/trp and neopterin and homocysteine concentrations (all P < 0.01). CONCLUSIONS: Increasing neopterin concentrations and kyn/trp with older age are in line with the view that aging in healthy people is associated with immune activation especially of the T-cell/macrophage system. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/15302611/Increasing_production_of_homocysteine_and_neopterin_and_degradation_of_tryptophan_with_older_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009912004000578 DB - PRIME DP - Unbound Medicine ER -