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Clobetasol propionate shampoo 0.05%: a new option to treat patients with moderate to severe scalp psoriasis.
J Drugs Dermatol. 2004 Jul-Aug; 3(4):367-73.JD

Abstract

Psoriasis is a chronic, papulosquamous condition that affects up to 2% of the U.S. population. Approximately 50% of patients with psoriasis have involvement of the scalp. This was a multicentre, randomized, vehicle-controlled, double-masked and parallel-group study. The aim was to evaluate the efficacy and safety of clobetasol propionate shampoo, 0.05% versus its corresponding vehicle in subjects aged 12 years and older with moderate to severe scalp psoriasis over a treatment period of 4 weeks. Recurrence of scalp psoriasis was assessed during a two week follow-up period. A total of 142 subjects were treated. Results after 4 weeks demonstrated that clobetasol propionate shampoo, 0.05% was with a similar safety profile significantly more effective than its vehicle. The novel short contact shampoo formulation of clobetasol propionate is convenient and efficacious and minimizes systemic exposure while being efficient, safe and well-tolerated in the treatment of moderate to severe scalp psoriasis.

Authors+Show Affiliations

Jarratt M
DermResearch, Inc. Austin, TX, USA.
Breneman D
No affiliation info available
Gottlieb AB
No affiliation info available
Poulin Y
No affiliation info available
Liu Y
No affiliation info available
Foley V
No affiliation info available

MeSH

Administration, TopicalAdultAnti-Inflammatory AgentsClobetasolDouble-Blind MethodFemaleHair PreparationsHumansMaleMiddle AgedPsoriasisScalp DermatosesSeverity of Illness IndexTreatment Outcome

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15303780

Citation

Jarratt, Michael, et al. "Clobetasol Propionate Shampoo 0.05%: a New Option to Treat Patients With Moderate to Severe Scalp Psoriasis." Journal of Drugs in Dermatology : JDD, vol. 3, no. 4, 2004, pp. 367-73.
Jarratt M, Breneman D, Gottlieb AB, et al. Clobetasol propionate shampoo 0.05%: a new option to treat patients with moderate to severe scalp psoriasis. J Drugs Dermatol. 2004;3(4):367-73.
Jarratt, M., Breneman, D., Gottlieb, A. B., Poulin, Y., Liu, Y., & Foley, V. (2004). Clobetasol propionate shampoo 0.05%: a new option to treat patients with moderate to severe scalp psoriasis. Journal of Drugs in Dermatology : JDD, 3(4), 367-73.
Jarratt M, et al. Clobetasol Propionate Shampoo 0.05%: a New Option to Treat Patients With Moderate to Severe Scalp Psoriasis. J Drugs Dermatol. 2004 Jul-Aug;3(4):367-73. PubMed PMID: 15303780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clobetasol propionate shampoo 0.05%: a new option to treat patients with moderate to severe scalp psoriasis. AU - Jarratt,Michael, AU - Breneman,Debra, AU - Gottlieb,Alice B, AU - Poulin,Yves, AU - Liu,Yin, AU - Foley,Valerie, PY - 2004/8/12/pubmed PY - 2004/12/16/medline PY - 2004/8/12/entrez SP - 367 EP - 73 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 3 IS - 4 N2 - Psoriasis is a chronic, papulosquamous condition that affects up to 2% of the U.S. population. Approximately 50% of patients with psoriasis have involvement of the scalp. This was a multicentre, randomized, vehicle-controlled, double-masked and parallel-group study. The aim was to evaluate the efficacy and safety of clobetasol propionate shampoo, 0.05% versus its corresponding vehicle in subjects aged 12 years and older with moderate to severe scalp psoriasis over a treatment period of 4 weeks. Recurrence of scalp psoriasis was assessed during a two week follow-up period. A total of 142 subjects were treated. Results after 4 weeks demonstrated that clobetasol propionate shampoo, 0.05% was with a similar safety profile significantly more effective than its vehicle. The novel short contact shampoo formulation of clobetasol propionate is convenient and efficacious and minimizes systemic exposure while being efficient, safe and well-tolerated in the treatment of moderate to severe scalp psoriasis. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/15303780/Clobetasol_propionate_shampoo_0_05:_a_new_option_to_treat_patients_with_moderate_to_severe_scalp_psoriasis_ DB - PRIME DP - Unbound Medicine ER -