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Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects.
Eur J Clin Nutr. 2005 Jan; 59(1):24-34.EJ

Abstract

OBJECTIVE

The aim of the present study was to investigate the effect of trans-18:1 isomers compared to other fatty acids, especially saturates, on the postprandial fatty acid composition of triacylglycerols (TAG) in chylomicrons and VLDL.

DESIGN

A randomised crossover experiment where five interesterified test fats with equal amounts of palmitic acid (P fat), stearic acid (S fat), trans-18:1 isomers (T fat), oleic acid (O fat), or linoleic acid (L fat) were tested.

SUBJECTS

A total of 16 healthy, normolipidaemic males (age 23+/-2 y) were recruited.

INTERVENTIONS

The participants ingested fat-rich test meals (1 g fat per kg body weight) and the fatty acid profiles of chylomicron and VLDL TAG were followed for 8 h.

RESULTS

The postprandial fatty acid composition of chylomicron TAG resembled that of the ingested fats. The fatty acids in chylomicron TAG were randomly distributed among the three positions in accordance with the distributions in test fats. Calculations of postprandial TAG concentrations from fatty acid data revealed increasing amounts up to 4 h but lower response curves (IAUC) for the two saturated fats in accordance with previous published data. The T fat gave results comparable to the O and L fats. The test fatty acids were much less reflected in VLDL TAG and there was no dietary influence on the response curves.

CONCLUSIONS

The fatty acid composition in the test fats as well as the positional distributions of these were maintained in the chylomicrons. No specific clearing of chylomicron TAG was observed in relation to time.

Authors+Show Affiliations

BioCentrum-DTU, Section of Biochemistry and Nutrition, Center of Advanced Food Studies, The Technical University of Denmark, Lyngby, Denmark. aby@dfvf.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15305178

Citation

Bysted, A, et al. "Effect of Dietary Fatty Acids On the Postprandial Fatty Acid Composition of Triacylglycerol-rich Lipoproteins in Healthy Male Subjects." European Journal of Clinical Nutrition, vol. 59, no. 1, 2005, pp. 24-34.
Bysted A, Hølmer G, Lund P, et al. Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects. Eur J Clin Nutr. 2005;59(1):24-34.
Bysted, A., Hølmer, G., Lund, P., Sandström, B., & Tholstrup, T. (2005). Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects. European Journal of Clinical Nutrition, 59(1), 24-34.
Bysted A, et al. Effect of Dietary Fatty Acids On the Postprandial Fatty Acid Composition of Triacylglycerol-rich Lipoproteins in Healthy Male Subjects. Eur J Clin Nutr. 2005;59(1):24-34. PubMed PMID: 15305178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects. AU - Bysted,A, AU - Hølmer,G, AU - Lund,P, AU - Sandström,B, AU - Tholstrup,T, PY - 2004/8/12/pubmed PY - 2005/4/9/medline PY - 2004/8/12/entrez SP - 24 EP - 34 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 1 N2 - OBJECTIVE: The aim of the present study was to investigate the effect of trans-18:1 isomers compared to other fatty acids, especially saturates, on the postprandial fatty acid composition of triacylglycerols (TAG) in chylomicrons and VLDL. DESIGN: A randomised crossover experiment where five interesterified test fats with equal amounts of palmitic acid (P fat), stearic acid (S fat), trans-18:1 isomers (T fat), oleic acid (O fat), or linoleic acid (L fat) were tested. SUBJECTS: A total of 16 healthy, normolipidaemic males (age 23+/-2 y) were recruited. INTERVENTIONS: The participants ingested fat-rich test meals (1 g fat per kg body weight) and the fatty acid profiles of chylomicron and VLDL TAG were followed for 8 h. RESULTS: The postprandial fatty acid composition of chylomicron TAG resembled that of the ingested fats. The fatty acids in chylomicron TAG were randomly distributed among the three positions in accordance with the distributions in test fats. Calculations of postprandial TAG concentrations from fatty acid data revealed increasing amounts up to 4 h but lower response curves (IAUC) for the two saturated fats in accordance with previous published data. The T fat gave results comparable to the O and L fats. The test fatty acids were much less reflected in VLDL TAG and there was no dietary influence on the response curves. CONCLUSIONS: The fatty acid composition in the test fats as well as the positional distributions of these were maintained in the chylomicrons. No specific clearing of chylomicron TAG was observed in relation to time. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15305178/Effect_of_dietary_fatty_acids_on_the_postprandial_fatty_acid_composition_of_triacylglycerol_rich_lipoproteins_in_healthy_male_subjects_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602028 DB - PRIME DP - Unbound Medicine ER -