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The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study.
Phytother Res. 2004 Jul; 18(7):561-5.PR

Abstract

The nitric oxide (NO) scavenging activities of traditional polyherbal drugs like abana, chyavanaprasha, geriforte, septilin, mentat and triphala were examined using sodium nitroprusside as a NO donor in vitro. All the drugs tested demonstrated direct scavenging of NO and were superior to Gingko biloba, which was used as a positive control. The extracts of various polyherbal drugs exhibited dose-dependent NO scavenging activities and the potency was in the following order: abana > chyavanaprasha > triphala > geriforte > septilin > mentat > Gingko biloba. The present results suggest that the traditional Indian polyherbal crude drugs may be potent and novel therapeutic agents for scavenging of NO, and thereby inhibit the pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite. These findings may also help to explain, at least in part, the pharmacological activities like rejuvenating, adaptogenic, anti-infection, anti-inflammatory, cardioprotective and neuroprotective activities of these traditional, clinically used non toxic drugs.

Authors+Show Affiliations

Department of Radiobiology, Kasturba Medical College, Manipal, India. gc.jagetia@kmc.manipal.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15305317

Citation

Jagetia, Ganesh Chandra, et al. "The Evaluation of Nitric Oxide Scavenging Activity of Certain Herbal Formulations in Vitro: a Preliminary Study." Phytotherapy Research : PTR, vol. 18, no. 7, 2004, pp. 561-5.
Jagetia GC, Rao SK, Baliga MS, et al. The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. Phytother Res. 2004;18(7):561-5.
Jagetia, G. C., Rao, S. K., Baliga, M. S., & S Babu, K. (2004). The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. Phytotherapy Research : PTR, 18(7), 561-5.
Jagetia GC, et al. The Evaluation of Nitric Oxide Scavenging Activity of Certain Herbal Formulations in Vitro: a Preliminary Study. Phytother Res. 2004;18(7):561-5. PubMed PMID: 15305317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. AU - Jagetia,Ganesh Chandra, AU - Rao,Shaival Kamalaksh, AU - Baliga,Manjeshwar Shrinath, AU - S Babu,Kiran, PY - 2004/8/12/pubmed PY - 2004/9/17/medline PY - 2004/8/12/entrez SP - 561 EP - 5 JF - Phytotherapy research : PTR JO - Phytother Res VL - 18 IS - 7 N2 - The nitric oxide (NO) scavenging activities of traditional polyherbal drugs like abana, chyavanaprasha, geriforte, septilin, mentat and triphala were examined using sodium nitroprusside as a NO donor in vitro. All the drugs tested demonstrated direct scavenging of NO and were superior to Gingko biloba, which was used as a positive control. The extracts of various polyherbal drugs exhibited dose-dependent NO scavenging activities and the potency was in the following order: abana > chyavanaprasha > triphala > geriforte > septilin > mentat > Gingko biloba. The present results suggest that the traditional Indian polyherbal crude drugs may be potent and novel therapeutic agents for scavenging of NO, and thereby inhibit the pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite. These findings may also help to explain, at least in part, the pharmacological activities like rejuvenating, adaptogenic, anti-infection, anti-inflammatory, cardioprotective and neuroprotective activities of these traditional, clinically used non toxic drugs. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/15305317/The_evaluation_of_nitric_oxide_scavenging_activity_of_certain_herbal_formulations_in_vitro:_a_preliminary_study_ L2 - https://doi.org/10.1002/ptr.1494 DB - PRIME DP - Unbound Medicine ER -