Tags

Type your tag names separated by a space and hit enter

Development of atopy and wheezing symptoms in relation to heredity and early pet keeping in a Swedish birth cohort.
Pediatr Allergy Immunol. 2004 Aug; 15(4):316-22.PA

Abstract

The role of pet keeping during infancy for the development of allergy and asthma is still controversial. The objective of this population-based birth cohort study was to assess the development of atopy and different wheezing phenotypes during the first 4 yr of life in relation to heredity and early pet keeping. The cohort comprised all 1228 infants living in a Swedish county who were born over a 1-yr period. The parents replied to repeated questionnaires and 817 of the children were skin prick tested both at 1 and 4 yr. Cat keeping during the first year of life was associated with an increased risk of a positive skin prick test to cat at 1 yr of age [odds ratio (OR) 2.2, 95% confidence interval (CI) 0.9-5.6], but neither with sensitivity nor clinical symptoms of allergy at 4 yr. Dog keeping during the first year of life was associated with an increased risk of early-onset transient wheezing, but only in children with parental asthma (adjusted OR 4.3, 95% CI 1.5-12.1). In contrast, early dog keeping had an inverse association with sensitivity to pollen allergen at 4 yr (adjusted OR 0.3, 95% CI 0.1-0.9) and late-onset wheezing (adjusted OR 0.4, 95% CI 0.2-1.0). Thus, pet keeping during the first year of life was not associated with an increased risk of atopy at 4 yr, although a positive SPT to cat was more common at 1 yr. Our findings may even suggest that dog keeping during the first year of life might provide some protection from pollen allergy and late-onset wheezing and increase the risk of early-onset transient wheezing in children with heredity for asthma.

Authors+Show Affiliations

Department of Paediatrics, Ostersund Hospital, Ostersund, Sweden. annasandin@telia.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15305940

Citation

Sandin, Anna, et al. "Development of Atopy and Wheezing Symptoms in Relation to Heredity and Early Pet Keeping in a Swedish Birth Cohort." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 15, no. 4, 2004, pp. 316-22.
Sandin A, Björkstén B, Bråbäck L. Development of atopy and wheezing symptoms in relation to heredity and early pet keeping in a Swedish birth cohort. Pediatr Allergy Immunol. 2004;15(4):316-22.
Sandin, A., Björkstén, B., & Bråbäck, L. (2004). Development of atopy and wheezing symptoms in relation to heredity and early pet keeping in a Swedish birth cohort. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 15(4), 316-22.
Sandin A, Björkstén B, Bråbäck L. Development of Atopy and Wheezing Symptoms in Relation to Heredity and Early Pet Keeping in a Swedish Birth Cohort. Pediatr Allergy Immunol. 2004;15(4):316-22. PubMed PMID: 15305940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of atopy and wheezing symptoms in relation to heredity and early pet keeping in a Swedish birth cohort. AU - Sandin,Anna, AU - Björkstén,Bengt, AU - Bråbäck,Lennart, PY - 2004/8/13/pubmed PY - 2004/12/24/medline PY - 2004/8/13/entrez SP - 316 EP - 22 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 15 IS - 4 N2 - The role of pet keeping during infancy for the development of allergy and asthma is still controversial. The objective of this population-based birth cohort study was to assess the development of atopy and different wheezing phenotypes during the first 4 yr of life in relation to heredity and early pet keeping. The cohort comprised all 1228 infants living in a Swedish county who were born over a 1-yr period. The parents replied to repeated questionnaires and 817 of the children were skin prick tested both at 1 and 4 yr. Cat keeping during the first year of life was associated with an increased risk of a positive skin prick test to cat at 1 yr of age [odds ratio (OR) 2.2, 95% confidence interval (CI) 0.9-5.6], but neither with sensitivity nor clinical symptoms of allergy at 4 yr. Dog keeping during the first year of life was associated with an increased risk of early-onset transient wheezing, but only in children with parental asthma (adjusted OR 4.3, 95% CI 1.5-12.1). In contrast, early dog keeping had an inverse association with sensitivity to pollen allergen at 4 yr (adjusted OR 0.3, 95% CI 0.1-0.9) and late-onset wheezing (adjusted OR 0.4, 95% CI 0.2-1.0). Thus, pet keeping during the first year of life was not associated with an increased risk of atopy at 4 yr, although a positive SPT to cat was more common at 1 yr. Our findings may even suggest that dog keeping during the first year of life might provide some protection from pollen allergy and late-onset wheezing and increase the risk of early-onset transient wheezing in children with heredity for asthma. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/15305940/Development_of_atopy_and_wheezing_symptoms_in_relation_to_heredity_and_early_pet_keeping_in_a_Swedish_birth_cohort_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0905-6157&date=2004&volume=15&issue=4&spage=316 DB - PRIME DP - Unbound Medicine ER -